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Fusion gene ID: 22348 |
FusionGeneSummary for MPHOSPH8_ATP8A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPHOSPH8_ATP8A2 | Fusion gene ID: 22348 | Hgene | Tgene | Gene symbol | MPHOSPH8 | ATP8A2 | Gene ID | 54737 | 51761 |
| Gene name | M-phase phosphoprotein 8 | ATPase phospholipid transporting 8A2 | |
| Synonyms | HSMPP8|TWA3|mpp8 | ATP|ATPIB|CAMRQ4|IB|ML-1 | |
| Cytomap | 13q12.11 | 13q12.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | M-phase phosphoprotein 8M-phase phosphoprotein, mppM-phase phosphoprotein, mpp8two hybrid-associated protein 3 with RanBPM | phospholipid-transporting ATPase IBATPase, aminophospholipid transporter, class I, type 8A, member 2ATPase, aminophospholipid transporter-like, class I, type 8A, member 2P4-ATPase flippase complex alpha subunit ATP8A2probable phospholipid-transporting | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q99549 | Q9NTI2 | |
| Ensembl transtripts involved in fusion gene | ENST00000414242, ENST00000361479, ENST00000496525, | ENST00000381655, ENST00000255283, ENST00000491840, | |
| Fusion gene scores | * DoF score | 3 X 7 X 2=42 | 6 X 4 X 5=120 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/42*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MPHOSPH8 [Title/Abstract] AND ATP8A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-AY-A54L-01A | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000414242 | ENST00000381655 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| In-frame | ENST00000414242 | ENST00000255283 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| 5CDS-intron | ENST00000414242 | ENST00000491840 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| In-frame | ENST00000361479 | ENST00000381655 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| In-frame | ENST00000361479 | ENST00000255283 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| 5CDS-intron | ENST00000361479 | ENST00000491840 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| intron-3CDS | ENST00000496525 | ENST00000381655 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| intron-3CDS | ENST00000496525 | ENST00000255283 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
| intron-intron | ENST00000496525 | ENST00000491840 | MPHOSPH8 | chr13 | 20208101 | + | ATP8A2 | chr13 | 26535713 | + |
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FusionProtFeatures for MPHOSPH8_ATP8A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPHOSPH8 | ATP8A2 |
| Heterochromatin component that specifically recognizesand binds methylated 'Lys-9' of histone H3 (H3K9me) and promotesrecruitment of proteins that mediate epigenetic repression(PubMed:20871592, PubMed:26022416). Mediates recruitment of theHUSH complex to H3K9me3 sites: the HUSH complex is recruited togenomic loci rich in H3K9me3 and is probably required to maintaintranscriptional silencing by promoting recruitment of SETDB1, ahistone methyltransferase that mediates further deposition ofH3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNAmethylation by recruiting DNMT3A to target CpG sites; these can besituated within the coding region of the gene (PubMed:20871592).Mediates down-regulation of CDH1 expression (PubMed:20871592).{ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:26022416}. | Catalytic component of a P4-ATPase flippase complexwhich catalyzes the hydrolysis of ATP coupled to the transport ofaminophospholipids from the outer to the inner leaflet of variousmembranes and ensures the maintenance of asymmetric distributionof phospholipids. Phospholipid translocation seems also to beimplicated in vesicle formation and in uptake of lipid signalingmolecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippasecomplex predomiminantly transports phosphatidylserine (PS) and toa lesser extent phosphatidylethanolamine (PE). Proposed tofunction in the generation and maintenance of phospholipidasymmetry in photoreceptor disk membranes and neuronal axonmembranes. May be involved in vesicle trafficking in neuronalcells. Involved in regulation of neurite outgrowth; acting insynergy with TMEM30A. Required for normal visual and auditoryfunction; involved in photoreceptor and inner ear spiral ganglioncell survival. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000361479 | + | 1 | 14 | 151_256 | 71 | 861 | Compositional bias | Note=Lys-rich |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000414242 | + | 1 | 13 | 151_256 | 71 | 868 | Compositional bias | Note=Lys-rich |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000361479 | + | 1 | 14 | 59_118 | 71 | 861 | Domain | Chromo |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000414242 | + | 1 | 13 | 59_118 | 71 | 868 | Domain | Chromo |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000361479 | + | 1 | 14 | 80_87 | 71 | 861 | Region | Histone H3K9me3 binding |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000414242 | + | 1 | 13 | 80_87 | 71 | 868 | Region | Histone H3K9me3 binding |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000361479 | + | 1 | 14 | 600_629 | 71 | 861 | Repeat | Note=ANK 1 |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000361479 | + | 1 | 14 | 633_662 | 71 | 861 | Repeat | Note=ANK 2 |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000361479 | + | 1 | 14 | 666_695 | 71 | 861 | Repeat | Note=ANK 3 |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000361479 | + | 1 | 14 | 699_728 | 71 | 861 | Repeat | Note=ANK 4 |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000414242 | + | 1 | 13 | 600_629 | 71 | 868 | Repeat | Note=ANK 1 |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000414242 | + | 1 | 13 | 633_662 | 71 | 868 | Repeat | Note=ANK 2 |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000414242 | + | 1 | 13 | 666_695 | 71 | 868 | Repeat | Note=ANK 3 |
| Hgene | >MPHOSPH8 | chr13:20208101 | chr13:26535713 | ENST00000414242 | + | 1 | 13 | 699_728 | 71 | 868 | Repeat | Note=ANK 4 |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 1007_1024 | 1061 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 1050_1148 | 1061 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 1_44 | 1061 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 299_323 | 1061 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 346_837 | 1061 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 67_71 | 1061 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 859_870 | 1061 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 891_920 | 1061 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 943_956 | 1061 | 1189 | Topological domain | Exoplasmic loop |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 95_276 | 1061 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 980_985 | 1061 | 1189 | Topological domain | Cytoplasmic |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 1025_1049 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 277_298 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 324_345 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 45_66 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 72_94 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 838_858 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 871_890 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 921_942 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 957_979 | 1061 | 1189 | Transmembrane | Helical |
| Tgene | ATP8A2 | chr13:20208101 | chr13:26535713 | ENST00000381655 | + | 32 | 37 | 986_1006 | 1061 | 1189 | Transmembrane | Helical |
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FusionGeneSequence for MPHOSPH8_ATP8A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MPHOSPH8_ENST00000414242_chr13_20208101_+_ATP8A2_ENST00000381655_chr13_26535713_+_199aa MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS >In-frame_MPHOSPH8_ENST00000414242_chr13_20208101_+_ATP8A2_ENST00000255283_chr13_26535713_+_199aa MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS >In-frame_MPHOSPH8_ENST00000361479_chr13_20208101_+_ATP8A2_ENST00000381655_chr13_26535713_+_199aa MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS >In-frame_MPHOSPH8_ENST00000361479_chr13_20208101_+_ATP8A2_ENST00000255283_chr13_26535713_+_199aa MEQVAEGARVTAVPVSAADSTEELAEVEEGVGVVGEDNDAAARGAEAFGDSEEDGEDVFEVEKILDMKTEGATMVLSSAHFWLGLFLVPT ACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MPHOSPH8_ENST00000414242_chr13_20208101_+_ATP8A2_ENST00000381655_chr13_26535713_+_597nt ATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGA GTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAG GTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACT GCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAG TCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAG ACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGT >In-frame_MPHOSPH8_ENST00000414242_chr13_20208101_+_ATP8A2_ENST00000255283_chr13_26535713_+_597nt ATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGA GTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAG GTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACT GCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAG TCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAG ACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGT >In-frame_MPHOSPH8_ENST00000361479_chr13_20208101_+_ATP8A2_ENST00000381655_chr13_26535713_+_597nt ATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGA GTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAG GTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACT GCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAG TCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAG ACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGT >In-frame_MPHOSPH8_ENST00000361479_chr13_20208101_+_ATP8A2_ENST00000255283_chr13_26535713_+_597nt ATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGA GTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAG GTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACT GCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAG TCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAG ACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MPHOSPH8_ENST00000414242_chr13_20208101_+_ATP8A2_ENST00000381655_chr13_26535713_+_6564nt GTTACGCCGCTGATGTGGAGTAGGGCCGAGCGCGGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCG GAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAG TCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGG ATGTGTTCGAGGTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTC TGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGC TGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGC TGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACG GAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGAT CTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACAC ATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTC CCAACTCGTCTGCAGTGCTTAGCCTAACTTTTGTTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTGTGAAATTAAAAACATT ATGTTTCACCAATATTTAAACATCAGTACTAGTTGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGAGGCCCATCCTGTGTAA TTGGAGCAGGGCACACTTGCTTCCTGTTGAGTTAACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCACTGTAGGCAGGTTGCTC TCCTGCTTTGATTCCTGTTTTGTGTGTAAAATTGGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCTATCGGGGTGGTCAACC TGAGAACATTTATTTGAACCTCTTAGCCACATTTCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCCGCACCCTCTCCAGGTG CACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCGCCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACTCAGTGCATGGCGGCCG ATGGGCAGCCAACCCAAACCCGCGCCTTTCCTTGTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTCTTCCACCGCCCTTCTC GTTCTGTAAAGAAAGAAAAGAAACATAGCCTTTCTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATGGGGCCACCCCACAGGT CAGAGTGGTGGTAGAACCCCTTCAGGACTCCCAGCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGACTGCTGGGCCTTTGGC ATCCACTTACATTAGAACCCACGTTTGTTTCAGAGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTTATAACATGCCTGCACA GCGAAGGAACACACCTGTCGCTCTTAGCTCTAGAGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACATTGAGTGGGGAGAACA AGACGACCACAGAAGTCCTCAGAAGGAGAAGGAAGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCCACCAGATCTTTGCAGT AGAAACTCTGAAATAGGCCTTGAGACCCAGACAATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAGACCTTCACACACAGTT CTAATTGAAAAGAATTCCAAACATTTCAGGGAAACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGTATCCCATCAGTGTTAG ACACAGGTACCTATCAGAATACGGCATATCCTGAATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACTTTCCCAACTGCAGAGT CCCACACTTAAATCTCAACAGAACCTAGATGTCTTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAACCTGCCTGGAGCCCTG TTCTCTGCTCTGGTTGCCAAACCAGATTTTTGGATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAATGGGAGTGGAGAGCATG TTTTGGATTTTCACTGTGGGGAAATGAATGAATTTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTCTTAGCTCTAGAGTCGG AGGATGAGTCAACCCTGTAGGAATGATTGTGCTAAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACCCTTTTTTGTCAGAAAT CTACAACCTACTGGGCATGGAAATGATTTAAAATATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGAGGTGACCAGGATGCAG AGAGGGCCTGAGGGGCAGCAGAACAATGCAATTCACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAAGGTGCATAGAACATTT TTAAATATCAGAGTACCCAGCAAGACGGAAGGACTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTAACACGACAAACCAAGG TGTATGGTTTCTTTGCACACCCAGAAAGGTGATGGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGTGCATTAGGCATCTTAA CTATTCATATTTTGTCTCATTTGGGAACTAAGCCTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAAACAGTTAGCTCTGTCT TGAACTTGAAGCCTTCCAAATCAGAATTATGTATTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTTACATTAGAGTTCATAT TTTCTGGGATTTAAGGATACAGGTGTATTTTCCTATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATGACAGACGCACACAGAA GAAAACATTAGAAGAGATGCCTTTCTATCCTCTCATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGCTGTAAATTGGTTTCTA GGAGGAGCAGCTGTCACTACGTGTGATGTATAATATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCTATCTTTAAATTGAGGT CAGAGTGTCACACACAACCCCTCCCCTGGGGCAGGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCAGCAAAAATGCCACATG GGGCTTGTCACTCCGCCAGACACTCACTGACTCACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTGACTCTGGATTGAGCTA AACTGGCAGAATCCACTCAGGCCAACCCTTGGTCTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTCTCTTCTCCTGGATGAC CCTGCAAAAGGAAGAGACCAGTTGTACTGTGGGCTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCAAGGGTAGCTGTGGAAA ACACGTATCAGGAGAGCAGAGTAGTCTGGATGAATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGGAGTGGAGCTGATGTGT CTGTCCTGCCTCAGTGCAGAATATTCCAGGCTTCTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACATGCACACATGAAAACAA AAACATGGTAACTCTTTTGGTTCGGCACACCATACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAACACTTGTAGAGGAATAT CCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTCAGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGCTTCAGGTTCGTCTCAC TATAGGGAGCTGGCTGTGAAAATCAGTAATAACTTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGCCTAGGTAACTAATGTC TTATAATGCATATGTATGTAAATATTACAGGATTTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAATTTCCATTTGTTATAAT AATGACCTTTAATCTTGTCATTTGGAACCATAAAGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTCTTAGACCATAGCTGAA TTGAATGTTTGCAAAACACTGCTATAGGATAAGGTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTTTCAGCCAGGGTTTGAG TTACTGCCCAGGGTCATCGTCTCAAAGTAATTCAAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCATCTCCTGGGATCCATAA AAAAATGTGAACAGGGAAATGGTGGCTAAGCAGAGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGGTCGAGTCAAAACATGG CATCCCCTGTTACACTCAAGAAATGTTTTCTTCATGTAAATGTTTATACGGGCATATATAATCACAATGGGAACAGTTAAAACCCCCTCC CTTCAAAAAAAGAAAATCTATATCAGTTGGGTTTGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTCAGTATAGCCTTCGGGG AGATTTAACCTCATTCTAGCCATTTTTCCATCCTGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTTTCGGAGGTGAGGGCCC AAGACCCCCATAATGACATCATTAGGCATTCTTGAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCCTTCATTTATTTTTTTT TCTCAGCATCCCAAGTTGTCCATCAGTACATTCCCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTAACTAATGTTCTGTTTA AAGCTCTCTTAATTTGTTGGCTATGAGTGATTTGTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCATTGAGCCAGCATAAATC TGAATGGGCAGAAGCCACAAACAAATGGGAGCAGAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATAATCCAGTGTTAACCTC TGAGGAACACCTCGGCTCTCCCAACTGAGGAGAGACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTTTCAAGTGACAATCTCG GGCTCTAGTTGCCTTTGAGATATCCACTCTGCTCTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAGATTAGCCCATAGGCAG TTCTTGTGACCTGGCTGAAGAAAGAAAGGAGACCTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTTTGATTTATGACAGAAA GAGGAAGAAGAAAGTTGGAGTAATAGCACTATCCAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTTATCAAGAGCCTTTTAT AGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCCGGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCACTTCCAATGGGATTGGA GTCTGTTGTATTCTTAAGAGATAGCCTGATATGTGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAAAAAAAAAAAAAAAAAA GGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTCATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGGTTTTCATGGATAAAAT CAATGTCAGTACTGAAACTCCTACTCTCCCCTCCCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAGGCCTGTGCAATGCCGC TTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCAGGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGTCACTGAATTGTCGTTC AAATGCATCATCTTTGTGGCGTCTTTCTCATGCGAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTGCCTGGATTGCTTAAAT ATTGTTTGTGATGGGGAGGTTTTAATCTGGTGATGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCTCCCAGCAGCGTGGGGG GTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCCTCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTCCTCTGGTTGTTAAATT ACAGCAGCACATTACAGTGCACTGGGTTCCCTCCTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTAGAAGTTTTGGGAGAAT >In-frame_MPHOSPH8_ENST00000414242_chr13_20208101_+_ATP8A2_ENST00000255283_chr13_26535713_+_954nt GTTACGCCGCTGATGTGGAGTAGGGCCGAGCGCGGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCG GAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAGCAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAG TCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATAATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGG ATGTGTTCGAGGTGGAGAAGATCCTGGACATGAAGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTC TGGTTCCTACTGCCTGTTTGATTGAAGATGTGGCATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGC TGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGGTGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGC TGGGCCGGAAGACGCCCCCGACGCTGTTCCGGGGCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACG GAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTTATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGAT CTTAGGAAAGAGATTCAGTTTGTTGCACCCAGTGTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACAC ATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGTTACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTC >In-frame_MPHOSPH8_ENST00000361479_chr13_20208101_+_ATP8A2_ENST00000381655_chr13_26535713_+_6531nt GGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCGGAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAG CAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATA ATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAGGTGGAGAAGATCCTGGACATGA AGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGG CATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGG TGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGG GCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTT ATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGT GTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGT TACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTG TTTATGTCGTTATGAAGCATTCAACTGTGCTCTGTGAGGTGTGAAATTAAAAACATTATGTTTCACCAATATTTAAACATCAGTACTAGT TGTCCTGGGAGAAAGGGAAAGGAGTTTTATGTTGCGTGAGAGGCCCATCCTGTGTAATTGGAGCAGGGCACACTTGCTTCCTGTTGAGTT AACTCAGAGGTTAAGTCCAACGGGCCACATGCAGACTTCACTGTAGGCAGGTTGCTCTCCTGCTTTGATTCCTGTTTTGTGTGTAAAATT GGCATAAACTTCTTGATTGCAGTGAAATCACAAAATTCTCTATCGGGGTGGTCAACCTGAGAACATTTATTTGAACCTCTTAGCCACATT TCCAGCAGGGCAAACCAACTGATGCCCTGGAAGAGTCTTCCGCACCCTCTCCAGGTGCACTCGGCCCAGTCCTGCCGCCGTGTCCAGGCG CCCCTCACCCCCACACCTGCTGCATGGCTGGCCACACCACTCAGTGCATGGCGGCCGATGGGCAGCCAACCCAAACCCGCGCCTTTCCTT GTTCCACTGCAGACTCAGATACAGATGCGAAAAATTCCTTCTTCCACCGCCCTTCTCGTTCTGTAAAGAAAGAAAAGAAACATAGCCTTT CTGCATATATTCTAAACGTCTCTCTGCCTCTGTCTGACATGGGGCCACCCCACAGGTCAGAGTGGTGGTAGAACCCCTTCAGGACTCCCA GCCGTGGTCAGGCTCTGAATACTCCCTTCCCAACATCCAGACTGCTGGGCCTTTGGCATCCACTTACATTAGAACCCACGTTTGTTTCAG AGCACATTTTGGACTTTCACTGTTGGGAAATGAATGAATTTATAACATGCCTGCACAGCGAAGGAACACACCTGTCGCTCTTAGCTCTAG AGTCAGAGGATGAGTAAACCCAGATGCAAGAGTATAGGACATTGAGTGGGGAGAACAAGACGACCACAGAAGTCCTCAGAAGGAGAAGGA AGGACACGGAGACACTGAGAGGAGGACACAGAGGAATCGCCACCAGATCTTTGCAGTAGAAACTCTGAAATAGGCCTTGAGACCCAGACA ATTGTCATGATCAGCCCAGTGTGTATGAGAGCTTAAACAAGACCTTCACACACAGTTCTAATTGAAAAGAATTCCAAACATTTCAGGGAA ACACCTTTTTAAAAAATATACTGACATGGTTTCCTTTCTGTATCCCATCAGTGTTAGACACAGGTACCTATCAGAATACGGCATATCCTG AATTATCTAAGACAAGGAAGTGAAGAGCGGAATCACTGACTTTCCCAACTGCAGAGTCCCACACTTAAATCTCAACAGAACCTAGATGTC TTCAGGCATGAATGTGAGCACCTGGAGCCCTTACTAAACAACCTGCCTGGAGCCCTGTTCTCTGCTCTGGTTGCCAAACCAGATTTTTGG ATGGCCTAAATACTTGTGGGCAACTGTTACTGGTGAAAAATGGGAGTGGAGAGCATGTTTTGGATTTTCACTGTGGGGAAATGAATGAAT TTATCACATGACTGTGCAGCGAAGGAGCACACCTGTCACTCTTAGCTCTAGAGTCGGAGGATGAGTCAACCCTGTAGGAATGATTGTGCT AAATTAGGAAATAACACTTTAGTGCACTTTGCTTCCTAACCCTTTTTTGTCAGAAATCTACAACCTACTGGGCATGGAAATGATTTAAAA TATGATCTGCATTGACTAAGAAAACTCATCCTCACTTATGAGGTGACCAGGATGCAGAGAGGGCCTGAGGGGCAGCAGAACAATGCAATT CACAGGTGAGGCTCCAAAAAGGGCCATTTCTTTCTCCCCAAGGTGCATAGAACATTTTTAAATATCAGAGTACCCAGCAAGACGGAAGGA CTGTCATGCAGGAACTCTAACACAAAATGTGCCTATGACTAACACGACAAACCAAGGTGTATGGTTTCTTTGCACACCCAGAAAGGTGAT GGCCAAGATACAGAGGAGAAACGAAAACTGGAATTGAATGTGCATTAGGCATCTTAACTATTCATATTTTGTCTCATTTGGGAACTAAGC CTATTTGGAAAGAGTGGATTAGAAATTGAATTCTTTGTCAAACAGTTAGCTCTGTCTTGAACTTGAAGCCTTCCAAATCAGAATTATGTA TTTAAGTGTGTGTTTGTGTTTGTTTGGGGTTTTTGTTTCTTACATTAGAGTTCATATTTTCTGGGATTTAAGGATACAGGTGTATTTTCC TATTCTCTTGAGAAGTAGACTAAACAATATTTGCAGTGATGACAGACGCACACAGAAGAAAACATTAGAAGAGATGCCTTTCTATCCTCT CATGTGGTTGAGCATTCTTACAGCCAAATGACTAAATTGGCTGTAAATTGGTTTCTAGGAGGAGCAGCTGTCACTACGTGTGATGTATAA TATTTAGCCAGGGCCAACTCAGGGGCTGTGTCATTTGTCCTATCTTTAAATTGAGGTCAGAGTGTCACACACAACCCCTCCCCTGGGGCA GGGTGGACTGGACTAGGTTGCATACGCTGGCTGTCAGCTCAGCAAAAATGCCACATGGGGCTTGTCACTCCGCCAGACACTCACTGACTC ACGGGCTGGCAGGTCACGCTCGGTTAGCGCTCCAGGGCCTGACTCTGGATTGAGCTAAACTGGCAGAATCCACTCAGGCCAACCCTTGGT CTACTGCTGTGTACAGACAGCCCAGTCCTGTGTTGAGTCTCTCTTCTCCTGGATGACCCTGCAAAAGGAAGAGACCAGTTGTACTGTGGG CTTAGTTCTGGGTTTCCACTGCACACTGACACGTGCCAGCAAGGGTAGCTGTGGAAAACACGTATCAGGAGAGCAGAGTAGTCTGGATGA ATACTCTGTGCTGATCAGAACGGGCTCGGTCATAATTTAGGAGTGGAGCTGATGTGTCTGTCCTGCCTCAGTGCAGAATATTCCAGGCTT CTTGACCAGGGTTATGTTCACCCATCTCCCAACACACACATGCACACATGAAAACAAAAACATGGTAACTCTTTTGGTTCGGCACACCAT ACAAAACGTGCTTTGGGGCGAGGAGTGCTGTTTCTTTTAACACTTGTAGAGGAATATCCTGAGAAGTGAACCTGGGCTTTGGGAGAGCTC AGCTGAGAATTCTGTTGACATTTTCTTTCCCTTGACAAGGCTTCAGGTTCGTCTCACTATAGGGAGCTGGCTGTGAAAATCAGTAATAAC TTGTCAAGAAGCAGTGAAAAATGCGGGGGGGTGGAAAGAGCCTAGGTAACTAATGTCTTATAATGCATATGTATGTAAATATTACAGGAT TTAAGGTTGAATTTTTTAAAAAGAAAGTTATAGTCTGTAATTTCCATTTGTTATAATAATGACCTTTAATCTTGTCATTTGGAACCATAA AGCATTTTTATCAGGTACCTCTGTTCCAAGGGATTTATGTCTTAGACCATAGCTGAATTGAATGTTTGCAAAACACTGCTATAGGATAAG GTGGTCTTTAGTTTTGAACGTGTGAAAGGACTGCACACTTTTCAGCCAGGGTTTGAGTTACTGCCCAGGGTCATCGTCTCAAAGTAATTC AAGGAGTGATTTAACATCAGCATTTGAAATGTAGTCTTCATCTCCTGGGATCCATAAAAAAATGTGAACAGGGAAATGGTGGCTAAGCAG AGCCTGAAATAATAACTTGGCAAAGAAATGAGTTTATCAGGTCGAGTCAAAACATGGCATCCCCTGTTACACTCAAGAAATGTTTTCTTC ATGTAAATGTTTATACGGGCATATATAATCACAATGGGAACAGTTAAAACCCCCTCCCTTCAAAAAAAGAAAATCTATATCAGTTGGGTT TGGTTTTGGTTCTTCATTGGCTCAAGGCAGTTAACTGTCTCAGTATAGCCTTCGGGGAGATTTAACCTCATTCTAGCCATTTTTCCATCC TGAAGGCCAAGAAGGACTATTAGAAGGGTTTTTGAGGGGTTTCGGAGGTGAGGGCCCAAGACCCCCATAATGACATCATTAGGCATTCTT GAAAGGTGTTAACAGACCAGCACGCTCGATGTGTTGTACCCTTCATTTATTTTTTTTTCTCAGCATCCCAAGTTGTCCATCAGTACATTC CCCTTCACCTTACCTGATCTTCATTTAATGCCCAGTCTGTAACTAATGTTCTGTTTAAAGCTCTCTTAATTTGTTGGCTATGAGTGATTT GTGAATCTGGGATGTAACCCTGAGTGAGGAGAAAAGGGCATTGAGCCAGCATAAATCTGAATGGGCAGAAGCCACAAACAAATGGGAGCA GAAAAGAAGGGCGAGCTCCCCCGCGCCGCACCCCGTGTATAATCCAGTGTTAACCTCTGAGGAACACCTCGGCTCTCCCAACTGAGGAGA GACAAAAGAGGGATTCTTTTTACACCCAGGCTGGCGCATTTTCAAGTGACAATCTCGGGCTCTAGTTGCCTTTGAGATATCCACTCTGCT CTTTCTCCCAGGCCTCAGACCAAGAAAAACATGCTCTCAAGATTAGCCCATAGGCAGTTCTTGTGACCTGGCTGAAGAAAGAAAGGAGAC CTGTTTGTTTTAAAAGTCGGGCGCAAAGTGTCAGGTGGCTTTGATTTATGACAGAAAGAGGAAGAAGAAAGTTGGAGTAATAGCACTATC CAAATAACCCTGCCCAGGAAACTTGGGGGTCAAGAGAGCTTATCAAGAGCCTTTTATAGGTAAGCTCTTCCGTGTGAAAGAGAAAAGGCC GGAAAGAGGGAGAGAGCCCAGAGAGCAGGCTGCGAACTCACTTCCAATGGGATTGGAGTCTGTTGTATTCTTAAGAGATAGCCTGATATG TGGTTTATAGGTGAATCAATAAACACCAACAACAACAAAAAAAAAAAAAAAAAAAAAGGAAGAAAAGAAAAAAAGGAAACCAGCCCTGTC ATGGAATTTCTCTCCTTCCCTGCACAGTAAAGACTTTTGGGTTTTCATGGATAAAATCAATGTCAGTACTGAAACTCCTACTCTCCCCTC CCGCCCCACTCTCCCCCGTTGCCCGAGATGGCCAAGTTCAGGCCTGTGCAATGCCGCTTCCCTCTGAGCCTCCCTCTCAAGGGCCACGCA GGCAGCTGCAGCAGGGCCAGCTGCAGGATGGGGCTGCCGGTCACTGAATTGTCGTTCAAATGCATCATCTTTGTGGCGTCTTTCTCATGC GAGCAAAGCCACGTGCTCTCCTGTCTGCTGTCACATCTGTGCCTGGATTGCTTAAATATTGTTTGTGATGGGGAGGTTTTAATCTGGTGA TGCAGAGGGAAGCAGGGCTGTGGGGGCACGTTTAATTGGCTCCCAGCAGCGTGGGGGGTGCTTCTATGGTGTGTGGGGTTTTTTGTTGCC TCCCTCTAGAAGTGTTACCGTTTTCACGTCCTATTAATGTCCTCTGGTTGTTAAATTACAGCAGCACATTACAGTGCACTGGGTTCCCTC CTGGAGTGAATACAAACGGAGGGCATCTACTTGTATTTTTAGAAGTTTTGGGAGAATTTAGTGATTTGTGGCTTTGATCAATCCTGTTGA >In-frame_MPHOSPH8_ENST00000361479_chr13_20208101_+_ATP8A2_ENST00000255283_chr13_26535713_+_921nt GGAACGCGAGGGGCTGCTGGGGTGTTTGTCGCAGCGGGTTTTCCTCGGCGGTTTGCGGAGCTGCTAGGATGGAGCAGGTTGCGGAGGGAG CAAGGGTGACCGCAGTCCCTGTGTCAGCTGCCGACAGCACTGAGGAGTTGGCCGAAGTCGAAGAAGGAGTTGGAGTAGTGGGCGAAGATA ATGACGCAGCCGCGAGAGGAGCGGAGGCCTTTGGCGACAGTGAGGAGGACGGAGAGGATGTGTTCGAGGTGGAGAAGATCCTGGACATGA AGACCGAGGGGGCAACTATGGTCCTGAGCTCCGCACACTTCTGGTTGGGATTATTTCTGGTTCCTACTGCCTGTTTGATTGAAGATGTGG CATGGAGAGCAGCCAAGCACACCTGCAAAAAGACATTGCTGGAGGAGGTGCAGGAGCTGGAAACCAAGTCTCGAGTCCTGGGAAAAGCGG TGCTGCGGGATAGCAATGGAAAGAGGCTGAACGAGCGCGACCGCCTGATCAAGAGGCTGGGCCGGAAGACGCCCCCGACGCTGTTCCGGG GCAGCTCCCTGCAGCAGGGCGTCCCGCATGGGTATGCTTTTTCTCAAGAAGAACACGGAGCTGTTAGTCAGGAAGAAGTCATCCGTGCTT ATGACACCACCAAAAAGAAATCCAGGAAGAAATAAGACATGAATTTTCCTGACTGATCTTAGGAAAGAGATTCAGTTTGTTGCACCCAGT GTTAACACATCTTTGTCAGAGAAGACTGGCGTCAGCAGCCAAAACACCAGGAAACACATTTCTGTGGCCTTAGCCAAGCAGTTTGTTAGT TACATATTCCCTCGCAAACCTGGAGTGCAGACCACAGGGGAAGCTATCTTTGCCCTCCCAACTCGTCTGCAGTGCTTAGCCTAACTTTTG |
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FusionGenePPI for MPHOSPH8_ATP8A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MPHOSPH8 | RANBP9, SH3BP4, DNMT3A, EHMT1, MPHOSPH8, MTRNR2L1, ENO1, MOV10, NXF1, BMI1, ZNF597, IFI16, HIST1H2BG, ERCC6, HCFC1, ILF3, NOP2, NUMA1, RPL24, MRPS12, RPS11, SAFB, UBTF, ZNF121, BRPF1, TRRAP, SAFB2, MATR3, TBC1D4, KHDRBS1, HECW1, ANKLE2, FAM208A, RPL36, FBXL6, ZNF638, MRPL18, PPHLN1, YIPF5, FAM208B, ZNF770, PHIP, TMEM33, IMP3, DDX28, ESYT2, NCOA5, DYNLRB1, UTP23, FAM195A, SPIRE2, USMG5, ZNF845, MB21D1, TSR3, RPP25L, LRWD1, SIRT1, ZEB1, HIST1H3A, ESAM | ATP8A2 | UIMC1, ZBTB8OS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MPHOSPH8_ATP8A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MPHOSPH8_ATP8A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ATP8A2 | C3808977 | CEREBELLAR ATAXIA, MENTAL RETARDATION, AND DYSEQUILIBRIUM SYNDROME 4 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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