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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2232

FusionGeneSummary for APOL6_FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: APOL6_FAU
Fusion gene ID: 2232
HgeneTgene
Gene symbol

APOL6

FAU

Gene ID

80830

2197

Gene nameapolipoprotein L6FAU, ubiquitin like and ribosomal protein S30 fusion
SynonymsAPOL-VI|APOLVIFAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap

22q12.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionapolipoprotein L6apolipoprotein L, 6apolipoprotein L-VIubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2018052320180522
UniProtAcc

Q9BWW8

P62861

Ensembl transtripts involved in fusion geneENST00000409652, ENST00000529639, 
ENST00000531743, ENST00000525297, 
ENST00000527548, ENST00000279259, 
ENST00000529259, ENST00000434372, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 6 X 2=84
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOL6 [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG251227APOL6chr22

36058447

-FAUchr11

64889283

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000409652ENST00000529639APOL6chr22

36058447

-FAUchr11

64889283

-
3UTR-3CDSENST00000409652ENST00000531743APOL6chr22

36058447

-FAUchr11

64889283

-
3UTR-3CDSENST00000409652ENST00000525297APOL6chr22

36058447

-FAUchr11

64889283

-
3UTR-3CDSENST00000409652ENST00000527548APOL6chr22

36058447

-FAUchr11

64889283

-
3UTR-3CDSENST00000409652ENST00000279259APOL6chr22

36058447

-FAUchr11

64889283

-
3UTR-3CDSENST00000409652ENST00000529259APOL6chr22

36058447

-FAUchr11

64889283

-
3UTR-3CDSENST00000409652ENST00000434372APOL6chr22

36058447

-FAUchr11

64889283

-

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FusionProtFeatures for APOL6_FAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APOL6

Q9BWW8

FAU

P62861

May affect the movement of lipids in the cytoplasm orallow the binding of lipids to organelles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for APOL6_FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APOL6_FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APOL6_FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for APOL6_FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPOL6C0021400Influenza1CTD_human