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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 22298

FusionGeneSummary for MORC2_PATZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: MORC2_PATZ1
Fusion gene ID: 22298
HgeneTgene
Gene symbol

MORC2

PATZ1

Gene ID

22880

23598

Gene nameMORC family CW-type zinc finger 2POZ/BTB and AT hook containing zinc finger 1
SynonymsCMT2Z|ZCW3|ZCWCC1MAZR|PATZ|RIAZ|ZBTB19|ZNF278|ZSG|dJ400N23
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionMORC family CW-type zinc finger protein 2zinc finger CW-type coiled-coil domain protein 1POZ-, AT hook-, and zinc finger-containing protein 1BTB-POZ domain zinc finger transcription factorMAZ-related factorPOZ-AT hook-zinc finger proteinprotein kinase A RI subunit alpha-associated proteinzinc finger and BTB domain-containing protein 19z
Modification date2018052320180519
UniProtAcc

Q9Y6X9

Q9HBE1

Ensembl transtripts involved in fusion geneENST00000397641, ENST00000215862, 
ENST00000469915, 		ENST00000266269, 
ENST00000405309, ENST00000351933, 
ENST00000215919, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MORC2 [Title/Abstract] AND PATZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-L3-A524-01AMORC2chr22

31363808

-PATZ1chr22

31731849

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397641ENST00000266269MORC2chr22

31363808

-PATZ1chr22

31731849

-
In-frameENST00000397641ENST00000405309MORC2chr22

31363808

-PATZ1chr22

31731849

-
In-frameENST00000397641ENST00000351933MORC2chr22

31363808

-PATZ1chr22

31731849

-
5CDS-intronENST00000397641ENST00000215919MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-3CDSENST00000215862ENST00000266269MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-3CDSENST00000215862ENST00000405309MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-3CDSENST00000215862ENST00000351933MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-intronENST00000215862ENST00000215919MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-3CDSENST00000469915ENST00000266269MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-3CDSENST00000469915ENST00000405309MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-3CDSENST00000469915ENST00000351933MORC2chr22

31363808

-PATZ1chr22

31731849

-
intron-intronENST00000469915ENST00000215919MORC2chr22

31363808

-PATZ1chr22

31731849

-

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FusionProtFeatures for MORC2_PATZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MORC2

Q9Y6X9

PATZ1

Q9HBE1

Exhibits a cytosolic function in lipogenesis, adipogenicdifferentiation, and lipid homeostasis by increasing the activityof ACLY, possibly preventing its dephosphorylation(PubMed:24286864). May act as a transcriptional repressor(PubMed:20225202). Down-regulates CA9 expression(PubMed:20110259). {ECO:0000269|PubMed:20110259,ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:24286864}. Transcriptional repressor.{ECO:0000269|PubMed:10713105}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03264_276-58538DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-0341_130-58538DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03292_314-58538Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03355_377-58538Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03383_405-58538Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03413_436-58538Zinc fingerC2H2-type 4
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03442_464-58538Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03495_518-58538Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST00000215919-03605_628-58538Zinc fingerC2H2-type 7
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15442_464445688Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15495_518445688Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15605_628445688Zinc fingerC2H2-type 7
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14442_464445642Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14495_518445642Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14605_628445642Zinc fingerC2H2-type 7
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15442_464445538Zinc fingerC2H2-type 5
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15495_518445538Zinc fingerC2H2-type 6
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15605_628445538Zinc fingerC2H2-type 7

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127282_362-455971Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127547_584-455971Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127741_761-455971Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127966_1016-455971Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126282_362221033Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126547_584221033Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126741_761221033Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126966_1016221033Coiled coilOntology_term=ECO:0000255
HgeneMORC2chr22:31363808chr22:31731849ENST00000215862-127490_544-455971Zinc fingerCW-type
HgeneMORC2chr22:31363808chr22:31731849ENST00000397641-126490_544221033Zinc fingerCW-type
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15264_276445688DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14264_276445642DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15264_276445538DNA bindingNote=A.T hook
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-1541_130445688DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-1441_130445642DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-1541_130445538DomainBTB
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15292_314445688Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15355_377445688Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15383_405445688Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST00000266269-15413_436445688Zinc fingerC2H2-type 4
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14292_314445642Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14355_377445642Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14383_405445642Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST00000351933-14413_436445642Zinc fingerC2H2-type 4
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15292_314445538Zinc fingerC2H2-type 1
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15355_377445538Zinc fingerC2H2-type 2
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15383_405445538Zinc fingerC2H2-type 3
TgenePATZ1chr22:31363808chr22:31731849ENST00000405309-15413_436445538Zinc fingerC2H2-type 4


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FusionGeneSequence for MORC2_PATZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000266269_chr22_31731849_-_265aa
MAFTNYSSLNRAQLTFEYLHTNSPAMLLLPPETVCAPTWPVMKTRCPARCVGSTCGQHTWQTTXRSTARGPATSAVSVTEVSPLPPTXRS
MLKPTTVFPFPRSPGTRSPSXMGEQRSTAPGPMATKKARNAHIRIRLRALTPMVTSQMPATXRRQRSRVPMALSPATWQSPKTKWSLMGR

>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000405309_chr22_31731849_-_115aa
MAFTNYSSLNRAQLTFEYLHTNSPAMLLLPPETVCAPTWPVMKTRCPARCVGSTCGQHTWQTTXRSTARGPATSAVSVTEVSRHQEPILN

>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000351933_chr22_31731849_-_219aa
MAFTNYSSLNRAQLTFEYLHTNSPAMLLLPPETVCAPTWPVMKTRCPARCVGSTCGQHTWQTTXRSTARGPATSAVSVTEKARNAHIRIR
LRALTPMVTSQMPATXRRQRSRVPMALSPATWQSPKTKWSLMGRRSTHALNVGASSALSPTXTNTSRRCMSGLSGAPWGTWALPLAHLSL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000266269_chr22_31731849_-_797nt
ATGGCTTTCACAAATTACAGCAGTCTGAATCGAGCTCAGCTAACCTTTGAATATCTGCACACAAATTCACCTGCAATGCTTCTTTTGCCA
CCCGAGACCGTCTGCGCTCCCACCTGGCCTGTCATGAAGACAAGGTGCCCTGCCAGGTGTGTGGGAAGTACTTGCGGGCAGCATACATGG
CAGACCACCTGAAGAAGCACAGCGAGGGGCCCAGCAACTTCTGCAGTATCTGTAACCGAGGTTTCTCCTCTGCCTCCTACTTAAAGGTCC
ATGTTAAAACCCACCACGGTGTTCCCCTTCCCCAGGTCTCCAGGCACCAGGAGCCCATCCTGAATGGGGGAGCAGCGTTCCACTGCGCCA
GGACCTATGGCAACAAAGAAGGCCAGAAATGCTCACATCAGGATCCGATTGAGAGCTCTGACTCCTATGGTGACCTCTCAGATGCCAGCG
ACCTGAAGACGCCAGAGAAGCAGAGTGCCAATGGCTCTTTCTCCTGCGACATGGCAGTCCCCAAAAACAAAATGGAGTCTGATGGGGAGA
AGAAGTACCCATGCCCTGAATGTGGGAGCTTCTTCCGCTCTAAGTCCTACTTGAACAAACACATCCAGAAGGTGCATGTCCGGGCTCTCG
GGGGCCCCCTGGGGGACCTGGGCCCTGCCCTTGGCTCACCTTTCTCTCCTCAGCAGAACATGTCTCTCCTCGAGTCCTTTGGGTTTCAGA

>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000405309_chr22_31731849_-_347nt
ATGGCTTTCACAAATTACAGCAGTCTGAATCGAGCTCAGCTAACCTTTGAATATCTGCACACAAATTCACCTGCAATGCTTCTTTTGCCA
CCCGAGACCGTCTGCGCTCCCACCTGGCCTGTCATGAAGACAAGGTGCCCTGCCAGGTGTGTGGGAAGTACTTGCGGGCAGCATACATGG
CAGACCACCTGAAGAAGCACAGCGAGGGGCCCAGCAACTTCTGCAGTATCTGTAACCGAGGTCTCCAGGCACCAGGAGCCCATCCTGAAT

>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000351933_chr22_31731849_-_659nt
ATGGCTTTCACAAATTACAGCAGTCTGAATCGAGCTCAGCTAACCTTTGAATATCTGCACACAAATTCACCTGCAATGCTTCTTTTGCCA
CCCGAGACCGTCTGCGCTCCCACCTGGCCTGTCATGAAGACAAGGTGCCCTGCCAGGTGTGTGGGAAGTACTTGCGGGCAGCATACATGG
CAGACCACCTGAAGAAGCACAGCGAGGGGCCCAGCAACTTCTGCAGTATCTGTAACCGAGAAGGCCAGAAATGCTCACATCAGGATCCGA
TTGAGAGCTCTGACTCCTATGGTGACCTCTCAGATGCCAGCGACCTGAAGACGCCAGAGAAGCAGAGTGCCAATGGCTCTTTCTCCTGCG
ACATGGCAGTCCCCAAAAACAAAATGGAGTCTGATGGGGAGAAGAAGTACCCATGCCCTGAATGTGGGAGCTTCTTCCGCTCTAAGTCCT
ACTTGAACAAACACATCCAGAAGGTGCATGTCCGGGCTCTCGGGGGCCCCCTGGGGGACCTGGGCCCTGCCCTTGGCTCACCTTTCTCTC
CTCAGCAGAACATGTCTCTCCTCGAGTCCTTTGGGTTTCAGATTGTTCAGTCGGCATTTGCGTCATCTTTAGTAGATCCTGAGGTTGACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000266269_chr22_31731849_-_2293nt
AGGAAATTTCGGGGAACCAAAAAAGGCTGGAAGAACATGAAGATGGAGCAGTCATAAACCACCCACTCAAGGACCATCTCCTTCAGGACC
ATCCACACGAGACTCAGATTGTCTGAATTGAGCTATCGCAACTTAATGCTAAAAGCTCCTTAAAGCTACAGATTTATGACATAGTTCCTT
CCAAAATATTACATCATAAATCATTGAGAAGATTAAAAAAAAACACTTGAAGAAATTGTAGTTTTAAACATCTCTGCATATATTTTGGAT
AGCTACTAGGTTACTTTAACTGTCATTAAGGAGCACAGACTTACTGAAGCTTTACTGGACAGAATCCTGGGAAATCGATATCATTATAAG
GTTATATTTCCCAGTTAGCGGGTGAAGGGCTGGAGACCTTATTGCAGTCATGGCTTTCACAAATTACAGCAGTCTGAATCGAGCTCAGCT
AACCTTTGAATATCTGCACACAAATTCACCTGCAATGCTTCTTTTGCCACCCGAGACCGTCTGCGCTCCCACCTGGCCTGTCATGAAGAC
AAGGTGCCCTGCCAGGTGTGTGGGAAGTACTTGCGGGCAGCATACATGGCAGACCACCTGAAGAAGCACAGCGAGGGGCCCAGCAACTTC
TGCAGTATCTGTAACCGAGGTTTCTCCTCTGCCTCCTACTTAAAGGTCCATGTTAAAACCCACCACGGTGTTCCCCTTCCCCAGGTCTCC
AGGCACCAGGAGCCCATCCTGAATGGGGGAGCAGCGTTCCACTGCGCCAGGACCTATGGCAACAAAGAAGGCCAGAAATGCTCACATCAG
GATCCGATTGAGAGCTCTGACTCCTATGGTGACCTCTCAGATGCCAGCGACCTGAAGACGCCAGAGAAGCAGAGTGCCAATGGCTCTTTC
TCCTGCGACATGGCAGTCCCCAAAAACAAAATGGAGTCTGATGGGGAGAAGAAGTACCCATGCCCTGAATGTGGGAGCTTCTTCCGCTCT
AAGTCCTACTTGAACAAACACATCCAGAAGGTGCATGTCCGGGCTCTCGGGGGCCCCCTGGGGGACCTGGGCCCTGCCCTTGGCTCACCT
TTCTCTCCTCAGCAGAACATGTCTCTCCTCGAGTCCTTTGGGTTTCAGATTGTTCAGTCGGCATTTGCGTCATCTTTAGTAGATCCTGAG
GTTGACCAGCAGCCCATGGGGCCTGAAGGGAAATGAGGCAGCTGCTGTGTCCCCACGGAAACAACCATCTGGGGACTGCTGGGAAATGCT
GTGAATGCGGAGGGAAGTGATGTTTGGGTTCTGTAGCTGAGAGATTTTTATTCATTTTTAACTGCCCCCCAACCCCACTCCAACTCCTTC
TCCACCACCCATTCTCCCAATGGTCTTTAGAAATAGATTTTCATCTGATATTCTGCAGAAATATCAATGAGACTTGGTATGGGACAGGGG
CAGAAAACACTACATAGGCCTCCAAGGCAAAACCAGTCCCAGTTTCTTTAATGGGAAGAAGCTGGAATTCCTGGTGCTCAATTCTTAGTG
ACCCCAATCCTATACCCAAATCTATGATATTCTGGGACCTCAGTGATTTTGGTCCCCTCCCACTTCTCTAGTTCGTCATCCTCCCTTCCC
ATATCCTTCAAAAGAACCACACTAGGGTCTCCACCTACTTATACAATGCGGATGCCCAACTGTTTTTAAGGAAGCCAGAAGCATCCCATG
GACCATGGGGTGAGTGTCCTCCAAGAGCCCCCTGAGCTCAGCCCTCTGCCTGGAGGGCTCCAGACCTTTCTGAGCCCTGCTTGGAGGCGA
GCATTTTCACTGCTAGGACAAGCTCAGCTGTTGAGGACACCCCCACCCCAAATTTCAGTTCTTACGTGATTTTAACCATTCAACATGCTG
TTGGGTTTTAATTCTCTAATTATTATTATTATTGTTATTATTTTTTAGGACCAGTTGTAGTGAATTGCTACTGAAAGCTATCCCAGGTGA
TACAGAGCTCTTTGTAAACCGCAGTCACACATTAGGGTTAGTATTAAACTTTGTTTAGATGTACCATAATTAACTTGGCTAGTTGATTGT
TTGAAGTCTATGGAAGAAATAGTTTTATGCAAAATTTTAAAAAATGCCAGTCTGGTCAGGGAAGTAGGGGGTTTCAATGCTGTTGGGAAC
CAGGAAGGTGGGACAGCCGGCAGGTAGGGACATTGTGTACCTCAGTTGTGTCACATGTGAGCAAGCCCAGGTTGACCTTGTGATGTGAAT

>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000405309_chr22_31731849_-_2223nt
AGGAAATTTCGGGGAACCAAAAAAGGCTGGAAGAACATGAAGATGGAGCAGTCATAAACCACCCACTCAAGGACCATCTCCTTCAGGACC
ATCCACACGAGACTCAGATTGTCTGAATTGAGCTATCGCAACTTAATGCTAAAAGCTCCTTAAAGCTACAGATTTATGACATAGTTCCTT
CCAAAATATTACATCATAAATCATTGAGAAGATTAAAAAAAAACACTTGAAGAAATTGTAGTTTTAAACATCTCTGCATATATTTTGGAT
AGCTACTAGGTTACTTTAACTGTCATTAAGGAGCACAGACTTACTGAAGCTTTACTGGACAGAATCCTGGGAAATCGATATCATTATAAG
GTTATATTTCCCAGTTAGCGGGTGAAGGGCTGGAGACCTTATTGCAGTCATGGCTTTCACAAATTACAGCAGTCTGAATCGAGCTCAGCT
AACCTTTGAATATCTGCACACAAATTCACCTGCAATGCTTCTTTTGCCACCCGAGACCGTCTGCGCTCCCACCTGGCCTGTCATGAAGAC
AAGGTGCCCTGCCAGGTGTGTGGGAAGTACTTGCGGGCAGCATACATGGCAGACCACCTGAAGAAGCACAGCGAGGGGCCCAGCAACTTC
TGCAGTATCTGTAACCGAGGTCTCCAGGCACCAGGAGCCCATCCTGAATGGGGGAGCAGCGTTCCACTGCGCCAGGACCTATGGCAACAA
AGAAGGCCAGAAATGCTCACATCAGGATCCGATTGAGAGCTCTGACTCCTATGGTGACCTCTCAGATGCCAGCGACCTGAAGACGCCAGA
GAAGCAGAGTGCCAATGGCTCTTTCTCCTGCGACATGGCAGTCCCCAAAAACAAAATGGAGTCTGATGGGGAGAAGAAGTACCCATGCCC
TGAATGTGGGAGCTTCTTCCGCTCTAAGTCCTACTTGAACAAACACATCCAGAAGGTGCATGTCCGGGCTCTCGGGGGCCCCCTGGGGGA
CCTGGGCCCTGCCCTTGGCTCACCTTTCTCTCCTCAGCAGAACATGTCTCTCCTCGAGTCCTTTGGGTTTCAGATTGTTCAGTCGGCATT
TGCGTCATCTTTAGTAGATCCTGAGGTTGACCAGCAGCCCATGGGGCCTGAAGGGAAATGAGGCAGCTGCTGTGTCCCCACGGAAACAAC
CATCTGGGGACTGCTGGGAAATGCTGTGAATGCGGAGGGAAGTGATGTTTGGGTTCTGTAGCTGAGAGATTTTTATTCATTTTTAACTGC
CCCCCAACCCCACTCCAACTCCTTCTCCACCACCCATTCTCCCAATGGTCTTTAGAAATAGATTTTCATCTGATATTCTGCAGAAATATC
AATGAGACTTGGTATGGGACAGGGGCAGAAAACACTACATAGGCCTCCAAGGCAAAACCAGTCCCAGTTTCTTTAATGGGAAGAAGCTGG
AATTCCTGGTGCTCAATTCTTAGTGACCCCAATCCTATACCCAAATCTATGATATTCTGGGACCTCAGTGATTTTGGTCCCCTCCCACTT
CTCTAGTTCGTCATCCTCCCTTCCCATATCCTTCAAAAGAACCACACTAGGGTCTCCACCTACTTATACAATGCGGATGCCCAACTGTTT
TTAAGGAAGCCAGAAGCATCCCATGGACCATGGGGTGAGTGTCCTCCAAGAGCCCCCTGAGCTCAGCCCTCTGCCTGGAGGGCTCCAGAC
CTTTCTGAGCCCTGCTTGGAGGCGAGCATTTTCACTGCTAGGACAAGCTCAGCTGTTGAGGACACCCCCACCCCAAATTTCAGTTCTTAC
GTGATTTTAACCATTCAACATGCTGTTGGGTTTTAATTCTCTAATTATTATTATTATTGTTATTATTTTTTAGGACCAGTTGTAGTGAAT
TGCTACTGAAAGCTATCCCAGGTGATACAGAGCTCTTTGTAAACCGCAGTCACACATTAGGGTTAGTATTAAACTTTGTTTAGATGTACC
ATAATTAACTTGGCTAGTTGATTGTTTGAAGTCTATGGAAGAAATAGTTTTATGCAAAATTTTAAAAAATGCCAGTCTGGTCAGGGAAGT
AGGGGGTTTCAATGCTGTTGGGAACCAGGAAGGTGGGACAGCCGGCAGGTAGGGACATTGTGTACCTCAGTTGTGTCACATGTGAGCAAG

>In-frame_MORC2_ENST00000397641_chr22_31363808_-_PATZ1_ENST00000351933_chr22_31731849_-_2150nt
AGGAAATTTCGGGGAACCAAAAAAGGCTGGAAGAACATGAAGATGGAGCAGTCATAAACCACCCACTCAAGGACCATCTCCTTCAGGACC
ATCCACACGAGACTCAGATTGTCTGAATTGAGCTATCGCAACTTAATGCTAAAAGCTCCTTAAAGCTACAGATTTATGACATAGTTCCTT
CCAAAATATTACATCATAAATCATTGAGAAGATTAAAAAAAAACACTTGAAGAAATTGTAGTTTTAAACATCTCTGCATATATTTTGGAT
AGCTACTAGGTTACTTTAACTGTCATTAAGGAGCACAGACTTACTGAAGCTTTACTGGACAGAATCCTGGGAAATCGATATCATTATAAG
GTTATATTTCCCAGTTAGCGGGTGAAGGGCTGGAGACCTTATTGCAGTCATGGCTTTCACAAATTACAGCAGTCTGAATCGAGCTCAGCT
AACCTTTGAATATCTGCACACAAATTCACCTGCAATGCTTCTTTTGCCACCCGAGACCGTCTGCGCTCCCACCTGGCCTGTCATGAAGAC
AAGGTGCCCTGCCAGGTGTGTGGGAAGTACTTGCGGGCAGCATACATGGCAGACCACCTGAAGAAGCACAGCGAGGGGCCCAGCAACTTC
TGCAGTATCTGTAACCGAGAAGGCCAGAAATGCTCACATCAGGATCCGATTGAGAGCTCTGACTCCTATGGTGACCTCTCAGATGCCAGC
GACCTGAAGACGCCAGAGAAGCAGAGTGCCAATGGCTCTTTCTCCTGCGACATGGCAGTCCCCAAAAACAAAATGGAGTCTGATGGGGAG
AAGAAGTACCCATGCCCTGAATGTGGGAGCTTCTTCCGCTCTAAGTCCTACTTGAACAAACACATCCAGAAGGTGCATGTCCGGGCTCTC
GGGGGCCCCCTGGGGGACCTGGGCCCTGCCCTTGGCTCACCTTTCTCTCCTCAGCAGAACATGTCTCTCCTCGAGTCCTTTGGGTTTCAG
ATTGTTCAGTCGGCATTTGCGTCATCTTTAGTAGATCCTGAGGTTGACCAGCAGCCCATGGGGCCTGAAGGGAAATGAGGCAGCTGCTGT
GTCCCCACGGAAACAACCATCTGGGGACTGCTGGGAAATGCTGTGAATGCGGAGGGAAGTGATGTTTGGGTTCTGTAGCTGAGAGATTTT
TATTCATTTTTAACTGCCCCCCAACCCCACTCCAACTCCTTCTCCACCACCCATTCTCCCAATGGTCTTTAGAAATAGATTTTCATCTGA
TATTCTGCAGAAATATCAATGAGACTTGGTATGGGACAGGGGCAGAAAACACTACATAGGCCTCCAAGGCAAAACCAGTCCCAGTTTCTT
TAATGGGAAGAAGCTGGAATTCCTGGTGCTCAATTCTTAGTGACCCCAATCCTATACCCAAATCTATGATATTCTGGGACCTCAGTGATT
TTGGTCCCCTCCCACTTCTCTAGTTCGTCATCCTCCCTTCCCATATCCTTCAAAAGAACCACACTAGGGTCTCCACCTACTTATACAATG
CGGATGCCCAACTGTTTTTAAGGAAGCCAGAAGCATCCCATGGACCATGGGGTGAGTGTCCTCCAAGAGCCCCCTGAGCTCAGCCCTCTG
CCTGGAGGGCTCCAGACCTTTCTGAGCCCTGCTTGGAGGCGAGCATTTTCACTGCTAGGACAAGCTCAGCTGTTGAGGACACCCCCACCC
CAAATTTCAGTTCTTACGTGATTTTAACCATTCAACATGCTGTTGGGTTTTAATTCTCTAATTATTATTATTATTGTTATTATTTTTTAG
GACCAGTTGTAGTGAATTGCTACTGAAAGCTATCCCAGGTGATACAGAGCTCTTTGTAAACCGCAGTCACACATTAGGGTTAGTATTAAA
CTTTGTTTAGATGTACCATAATTAACTTGGCTAGTTGATTGTTTGAAGTCTATGGAAGAAATAGTTTTATGCAAAATTTTAAAAAATGCC
AGTCTGGTCAGGGAAGTAGGGGGTTTCAATGCTGTTGGGAACCAGGAAGGTGGGACAGCCGGCAGGTAGGGACATTGTGTACCTCAGTTG


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FusionGenePPI for MORC2_PATZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MORC2HDAC4, NCOA3, CUL2, HECW2, DHX8, MORC1, NTRK1, RRBP1, HIST1H2BG, HNRNPD, SORT1, SGTB, MAXPATZ1MITF, RNF4, AR, BACH2, BACH1, PRKAR1A, BCL6, SOX2, TP53, CLEC11A, PRG2, CLK1, NR2C2, RBPJ, FOXJ2, ESR1, PATZ1, PCGF1, POU5F1, P4HA3, OMD, APOBEC3D, FGF3, H2AFY2, ZNF169, RPL18A, SIRT6, AIPL1, MIOS, FGFR1OP, PDE5A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MORC2_PATZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MORC2_PATZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMORC2C4225243CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2Z2ORPHANET;UNIPROT