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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22294

FusionGeneSummary for MON2_PIP4K2C

check button Fusion gene summary
Fusion gene informationFusion gene name: MON2_PIP4K2C
Fusion gene ID: 22294
HgeneTgene
Gene symbol

MON2

PIP4K2C

Gene ID

23041

79837

Gene nameMON2 homolog, regulator of endosome-to-Golgi traffickingphosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Synonyms-PIP5K2C
Cytomap

12q14.1

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein MON2 homologMON2 regulator of endosome-to-Golgi traffickingphosphatidylinositol 5-phosphate 4-kinase type-2 gammaPI(5)P 4-kinase type II gammaPIP4KII-gammaphosphatidylinositol 4-phosphate 5-kinasephosphatidylinositol 5-phosphate 4-kinase type II gammaphosphatidylinositol-4-phosphate 5-kinase, type II, gamma
Modification date2018052220180519
UniProtAcc

Q7Z3U7

Q8TBX8

Ensembl transtripts involved in fusion geneENST00000280379, ENST00000393632, 
ENST00000393630, ENST00000546600, 
ENST00000552738, ENST00000393629, 
ENST00000552115, ENST00000549378, 
ENST00000551397, 
ENST00000422156, 
ENST00000540759, ENST00000550465, 
ENST00000354947, 
Fusion gene scores* DoF score6 X 6 X 4=1449 X 6 X 5=270
# samples 69
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MON2 [Title/Abstract] AND PIP4K2C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A9RU-01AMON2chr12

62943610

+PIP4K2Cchr12

57989671

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000280379ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000280379ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000280379ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000280379ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393632ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393632ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393632ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393632ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393630ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393630ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393630ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393630ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000546600ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000546600ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000546600ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000546600ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552738ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552738ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552738ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552738ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393629ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393629ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393629ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000393629ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552115ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552115ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552115ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
5CDS-intronENST00000552115ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000549378ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000549378ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000549378ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000549378ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000551397ENST00000422156MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000551397ENST00000540759MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000551397ENST00000550465MON2chr12

62943610

+PIP4K2Cchr12

57989671

+
intron-intronENST00000551397ENST00000354947MON2chr12

62943610

+PIP4K2Cchr12

57989671

+

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FusionProtFeatures for MON2_PIP4K2C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MON2

Q7Z3U7

PIP4K2C

Q8TBX8

May play an important role in the production ofPhosphatidylinositol bisphosphate (PIP2), in the endoplasmicreticulum. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MON2_PIP4K2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MON2_PIP4K2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MON2GGA1, GGA3, MMS19, EGFR, ANKFY1, ROCK1, PAAF1, TNFSF13B, CA14, NTRK1, PTPRN2, VASN, SIGLECL1, OPRM1, PTPRN, STOM, MTNR1BPIP4K2CELAVL1, APP, PIP4K2C, FBXO25, CSNK2A2, ARL6IP4, EAF1, LZTS2, ZRANB2, EPB41L3, CSNK2A1, CSNK2B, DDX23, MTPN, MYL9, NCAPD3, PRPF8, SKP1, MED4, NF2, PIP4K2A, ARHGAP22, AHCYL2, GPBP1L1, PRICKLE3, HIF1AN, TULP3, ZNF428, CAMKV, POC1B, SUN2, TNFRSF19, C16orf71, GSPT2, APBA3, TNFRSF1A, HSD17B10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MON2_PIP4K2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MON2_PIP4K2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePIP4K2CC0036341Schizophrenia2PSYGENET
TgenePIP4K2CC0005586Bipolar Disorder1PSYGENET