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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22292

FusionGeneSummary for MON2_CHGB

check button Fusion gene summary
Fusion gene informationFusion gene name: MON2_CHGB
Fusion gene ID: 22292
HgeneTgene
Gene symbol

MON2

CHGB

Gene ID

23041

1114

Gene nameMON2 homolog, regulator of endosome-to-Golgi traffickingchromogranin B
Synonyms-SCG1
Cytomap

12q14.1

20p12.3

Type of geneprotein-codingprotein-coding
Descriptionprotein MON2 homologMON2 regulator of endosome-to-Golgi traffickingsecretogranin-1cgBsecretogranin Bsecretogranin IsgI
Modification date2018052220180523
UniProtAcc

Q7Z3U7

P05060

Ensembl transtripts involved in fusion geneENST00000280379, ENST00000393632, 
ENST00000393630, ENST00000546600, 
ENST00000552738, ENST00000393629, 
ENST00000552115, ENST00000549378, 
ENST00000551397, 
ENST00000378961, 
ENST00000488832, 
Fusion gene scores* DoF score6 X 6 X 4=1442 X 2 X 2=8
# samples 62
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MON2 [Title/Abstract] AND CHGB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC042679MON2chr12

62926331

+CHGBchr20

5904344

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000280379ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
5CDS-intronENST00000280379ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
In-frameENST00000393632ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
5CDS-intronENST00000393632ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
In-frameENST00000393630ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
5CDS-intronENST00000393630ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
In-frameENST00000546600ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
5CDS-intronENST00000546600ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
In-frameENST00000552738ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
5CDS-intronENST00000552738ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
In-frameENST00000393629ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
5CDS-intronENST00000393629ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
In-frameENST00000552115ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
5CDS-intronENST00000552115ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
intron-3CDSENST00000549378ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
intron-intronENST00000549378ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+
intron-3CDSENST00000551397ENST00000378961MON2chr12

62926331

+CHGBchr20

5904344

+
intron-intronENST00000551397ENST00000488832MON2chr12

62926331

+CHGBchr20

5904344

+

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FusionProtFeatures for MON2_CHGB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MON2

Q7Z3U7

CHGB

P05060

Secretogranin-1 is a neuroendocrine secretory granuleprotein, which may be the precursor for other biologically activepeptides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MON2_CHGB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MON2_ENST00000280379_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0aa

>In-frame_MON2_ENST00000393632_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0aa

>In-frame_MON2_ENST00000393630_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0aa

>In-frame_MON2_ENST00000546600_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0aa

>In-frame_MON2_ENST00000552738_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0aa

>In-frame_MON2_ENST00000393629_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0aa

>In-frame_MON2_ENST00000552115_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MON2_ENST00000280379_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000393632_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000393630_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000546600_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000552738_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000393629_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000552115_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_MON2_ENST00000280379_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000393632_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000393630_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000546600_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000552738_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000393629_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt

>In-frame_MON2_ENST00000552115_chr12_62926331_+_CHGB_ENST00000378961_chr20_5904344_+_0nt


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FusionGenePPI for MON2_CHGB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MON2_CHGB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MON2_CHGB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHGBC0036341Schizophrenia3PSYGENET
TgeneCHGBC0221765Chronic schizophrenia1PSYGENET