	FusionGeneSummary
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	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 22286

FusionGeneSummary for MOK_HSP90AA1

Fusion gene summary

Fusion gene information	Fusion gene name: MOK_HSP90AA1
	Fusion gene ID: 22286
		Hgene	Tgene
	Gene symbol	MOK	HSP90AA1
	Gene ID	5891	3320
	Gene name	MOK protein kinase	heat shock protein 90 alpha family class A member 1
	Synonyms	RAGE\|RAGE-1\|RAGE1\|STK30	EL52\|HEL-S-65p\|HSP86\|HSP89A\|HSP90A\|HSP90N\|HSPC1\|HSPCA\|HSPCAL1\|HSPCAL4\|HSPN\|Hsp103\|Hsp89\|Hsp90\|LAP-2\|LAP2
	Cytomap	14q32.31	14q32.31
	Type of gene	protein-coding	protein-coding
	Description	MAPK/MAK/MRK overlapping kinaserenal cell carcinoma antigenrenal tumor antigen 1	heat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shock
	Modification date	20180523	20180527
	UniProtAcc	Q9UQ07	P07900
	Ensembl transtripts involved in fusion gene	ENST00000193029, ENST00000522874, ENST00000361847, ENST00000524214, ENST00000561150, ENST00000517966, ENST00000523231, ENST00000524370, ENST00000522867, ENST00000520266, ENST00000519058, ENST00000522534,	ENST00000216281, ENST00000334701, ENST00000441629, ENST00000558600,
Fusion gene scores	* DoF score	7 X 6 X 5=210	18 X 19 X 6=2052
	# samples	8	23
	** MAII score	log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/2052*10)=-3.15732496466268 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MOK [Title/Abstract] AND HSP90AA1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HSP90AA1	GO:0001934	positive regulation of protein phosphorylation	19363271
Tgene	HSP90AA1	GO:0007004	telomere maintenance via telomerase	10197982
Tgene	HSP90AA1	GO:0031396	regulation of protein ubiquitination	16809764
Tgene	HSP90AA1	GO:0032273	positive regulation of protein polymerization	19363271
Tgene	HSP90AA1	GO:0045040	protein import into mitochondrial outer membrane	15644312
Tgene	HSP90AA1	GO:0051131	chaperone-mediated protein complex assembly	15644312
Tgene	HSP90AA1	GO:0051973	positive regulation of telomerase activity	10197982
Tgene	HSP90AA1	GO:1902949	positive regulation of tau-protein kinase activity	19363271
Tgene	HSP90AA1	GO:1905323	telomerase holoenzyme complex assembly	10197982

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BLCA	TCGA-UY-A78K-01A	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
TCGA	LD	BRCA	TCGA-A7-A6VV-01A	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-intron	ENST00000193029	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-intron	ENST00000193029	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-intron	ENST00000193029	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-5UTR	ENST00000193029	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000522874	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000522874	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000522874	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-5UTR	ENST00000522874	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000361847	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000361847	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000361847	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-5UTR	ENST00000361847	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000524214	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000524214	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-intron	ENST00000524214	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5CDS-5UTR	ENST00000524214	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000561150	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000561150	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000561150	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000561150	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000517966	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000517966	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000517966	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000517966	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000523231	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000523231	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000523231	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000523231	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000524370	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000524370	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000524370	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000524370	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522867	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522867	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522867	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000522867	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000520266	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000520266	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000520266	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000520266	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000519058	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000519058	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000519058	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000519058	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522534	ENST00000216281	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522534	ENST00000334701	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-intron	ENST00000522534	ENST00000441629	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
intron-5UTR	ENST00000522534	ENST00000558600	MOK	chr14	102749815	-	HSP90AA1	chr14	102568419	-
5UTR-intron	ENST00000193029	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5UTR-intron	ENST00000193029	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5UTR-intron	ENST00000193029	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5UTR-5UTR	ENST00000193029	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000522874	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000522874	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000522874	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-5UTR	ENST00000522874	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000361847	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000361847	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000361847	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-5UTR	ENST00000361847	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000524214	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000524214	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-intron	ENST00000524214	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
5CDS-5UTR	ENST00000524214	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000561150	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000561150	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000561150	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000561150	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000517966	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000517966	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000517966	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000517966	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000523231	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000523231	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000523231	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000523231	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000524370	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000524370	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000524370	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000524370	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522867	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522867	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522867	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000522867	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000520266	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000520266	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000520266	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000520266	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000519058	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000519058	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000519058	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000519058	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522534	ENST00000216281	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522534	ENST00000334701	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-intron	ENST00000522534	ENST00000441629	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-
intron-5UTR	ENST00000522534	ENST00000558600	MOK	chr14	102729883	-	HSP90AA1	chr14	102568422	-

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FusionProtFeatures for MOK_HSP90AA1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MOK Q9UQ07	HSP90AA1 P07900
Able to phosphorylate several exogenous substrates andto undergo autophosphorylation. Negatively regulates cilium lengthin a cAMP and mTORC1 signaling-dependent manner.{ECO:0000250\|UniProtKB:Q9WVS4}.	Molecular chaperone that promotes the maturation,structural maintenance and proper regulation of specific targetproteins involved for instance in cell cycle control and signaltransduction. Undergoes a functional cycle that is linked to itsATPase activity which is essential for its chaperone activity.This cycle probably induces conformational changes in the clientproteins, thereby causing their activation. Interacts dynamicallywith various co-chaperones that modulate its substraterecognition, ATPase cycle and chaperone function (PubMed:11274138,PubMed:15577939, PubMed:15937123, PubMed:27353360,PubMed:29127155). Engages with a range of client protein classesvia its interaction with various co-chaperone proteins orcomplexes, that act as adapters, simultaneously able to interactwith the specific client and the central chaperone itself(PubMed:29127155). Recruitment of ATP and co-chaperone followed byclient protein forms a functional chaperone. After the completionof the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformationand finally, ADP is released from HSP90 which acquires an openconformation for the next cycle (PubMed:27295069,PubMed:26991466). Apart from its chaperone activity, it also playsa role in the regulation of the transcription machinery. HSP90 andits co-chaperones modulate transcription at least at threedifferent levels (PubMed:25973397). In the first place, they alterthe steady-state levels of certain transcription factors inresponse to various physiological cues(PubMed:25973397). Second,they modulate the activity of certain epigenetic modifiers, suchas histone deacetylases or DNA methyl transferases, and therebyrespond to the change in the environment (PubMed:25973397). Third,they participate in the eviction of histones from the promoterregion of certain genes and thereby turn on gene expression(PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) andmediates LPS-induced inflammatory response, including TNFsecretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).{ECO:0000269\|PubMed:11274138, ECO:0000269\|PubMed:11276205,ECO:0000269\|PubMed:15577939, ECO:0000269\|PubMed:15937123,ECO:0000269\|PubMed:24613385, ECO:0000269\|PubMed:27353360,ECO:0000269\|PubMed:29127155, ECO:0000303\|PubMed:25973397,ECO:0000303\|PubMed:26991466, ECO:0000303\|PubMed:27295069}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MOK_HSP90AA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MOK_HSP90AA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
MOK	MAPK6, SDF4, INSR, ZNF223, HUWE1, WDR18, HIST1H1D, PNPO, NAA50, CAMK2D, IMPDH1	HSP90AA1	AR, FANCA, FANCC, SMYD3, CDC37, STARD13, BAG4, CHTF18, NOS3, GUCY1B3, HCFC1, MYC, RALBP1, HSF1, TUBA1A, ESR1, FES, CSNK2A1, CSNK2A2, TERT, AKT1, HSP90AA1, RPS3A, NR3C1, TP53, DAP3, SIM1, MYOD1, STIP1, PIM1, HSPA8, EPRS, HSPA1A, SGTA, RAF1, APAF1, CUL4A, STAT3, FNIP1, ERN1, EIF2AK3, IRS4, ARNTL, HIF1A, NPAS2, SRC, AHR, PPARA, FKBP5, GNA12, AHSA1, AHSA2, PTGES3, ERBB2, TGFBR1, TGFBR2, TJP1, FLT3, GUCY1A2, DAPK1, STUB1, RIPK1, MST1R, VCP, HDAC6, RPS3, HSPA4, RPS6, UBE2N, SIN3A, PAK1, JUN, PRKCZ, COPS3, PPP5C, CDK11B, TTI2, MGMT, SP1, STK11, FKBP4, AIP, ABL1, TSSK6, HIST3H3, VEGFA, SMYD2, EGFR, PRMT5, CFTR, ESR2, JAK2, HSP90AB1, HES1, CUL5, PI4K2B, PI4K2A, H2AFX, APP, FGFR3, USP50, RARRES3, CDK5R1, SENP3, PRKAA1, AGO4, CD4, BCR, MAP3K3, HDAC5, MYOCD, MDM2, DYRK2, PRKCI, LRRK2, FBXW8, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, MAP3K7, PSMA3, GBA, EIF2AK1, SVIL, CALM1, NTRK1, FKBPL, CDKN1A, BECN1, BCL2, CHEK1, ATR, REV1, SUGT1, SKP1, PPIL2, LCK, FYN, FKBP8, NDRG1, RAD21, CDC73, CDK9, CDK4, SIRT1, ARRB1, SLC2A4, CHUK, ALG2, MKKS, RCAN1, ISG15, MAP3K14, RNF114, PINK1, POLH, TNK2, NLRP3, NLRP2, NOD1, NLRP4, MIF, UCHL1, STRADA, KCNH2, EPAS1, HIF3A, PIWIL2, PPARD, STK36, GSK3B, CSNK1A1, HOPX, CUL3, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, GRK6, PPP2R1A, MID1, EEF1A1, MET, HDAC8, BRMS1, IKBKB, DSN1, NSL1, PMF1, MIS12, BCL6, IRAK1, BLM, TERF2, NUDC, PAFAH1B1, NUDCD2, DNAJC7, PPID, TARDBP, SNRPE, TUBG1, ACVRL1, STK33, GRK5, TYMP, NOX5, UBASH3B, GRB2, SHC1, IP6K2, MTRNR2L1, FBXO6, SNCA, IRF3, TBK1, PACRG, PARK2, HNRNPA1, RPS15A, NCL, SLC25A5, RPL7, RPL17, HSP90AB3P, TUFM, SSR3, RPL32, RPL5, RPS16, TXNDC5, RPS20, MARCKS, HSP90AA5P, RPL3, HSP90AB2P, LMAN1, SUPT5H, RPL23A, RPL29, WASL, NLRP12, CFLAR, CCT2, TRAF3IP1, MYLK2, CCDC117, TTC9C, TTC4, PLCE1, CDK11A, EFTUD2, CNOT6, PRPF8, FLII, CALD1, USP19, NUDCD3, UNC45A, FAM83H, CACYBP, TAB1, TAB2, CEP97, IKBKG, DYNC1H1, SCRIB, PRR14L, CHORDC1, EDRF1, TOMM34, BAG2, ST13, POLR2E, RPAP3, SNRNP200, PIH1D1, URI1, MLF2, CDC37L1, YTHDC2, HSPA7, HSPA6, HSPA5, HSPA2, HSPA1L, HSPA9, KCNQ4, TCP1, HSPH1, PRKDC, GNAI2, XPO1, PKM, GAPDH, PGK1, LDHA, ALDOA, MDH1, MTHFD1, PSAT1, FASN, NANS, ACTG1, TPM3, FLNA, MYH9, SPTAN1, NUMA1, ACTN1, UBA1, PSMD1, PSMB5, AARS, EEF2, EIF3H, RPLP0, RPS4X, C12orf10, IARS2, RPSA, FN1, VCAM1, AMHR2, ICK, PSKH1, EIF2AK2, ARAF, FER, PSKH2, PKN2, MAST2, PRKACB, CDK15, LIMK2, MAP3K8, MERTK, DYRK4, TIE1, NPRL2, MAPK7, TESK2, MAP3K6, TNK1, EPHB6, CDK7, CSF1R, MAP3K12, EPHB1, ACVR1C, DDR2, FASTK, MYLK4, KSR2, BMPR1A, FRK, PRKY, MOS, MAP3K15, MYO3B, MAP2K5, SGK2, GSK3A, INSRR, ALPK1, GRK4, SGK1, TNNI3K, TSSK2, AXL, ERBB3, FGFR1, MATK, ITK, CLK3, NTRK3, FLT4, ACVR1B, DCLK2, NTRK2, MAP4K4, ACVR2B, SGK3, MAP3K2, TYK2, CAMKK1, NEK11, KSR1, PRKCB, WNK4, SRPK1, STYK1, HCK, AURKC, BTK, PRKG2, MAP2K7, MAPK15, LYN, PRKX, JAK1, TP53RK, FBXW2, FBXO38, FBXO25, SKP2, TRIM56, KLHL38, FBXO24, FBXL3, FBXW11, WSB2, KBTBD4, FBXL2, FBXL12, KLHL6, ENC1, KCTD8, GAN, KLHL25, FBXL14, FBXW7, FBXO9, KLHL22, PRPF19, KLHL26, RAPSN, FBXO18, FBXL15, KLHL10, FBXL8, TRIM17, FBXL18, KLHL36, LNX1, RNF19B, ASB4, RNF10, BTRC, KLHL34, ARMC5, DET1, KLHL14, VPS18, FBXO28, FBXO17, RFWD3, FBXO27, FBXL13, ASB2, NHLRC1, SF3B3, KBTBD7, FBXO3, RAB40A, ANAPC2, AREL1, KLHL15, WWP1, PCGF1, HECTD3, TRIM49, KLHL1, TRIM10, KLHL23, TRIM2, ZBTB20, KLHL29, KLHL32, SH3RF2, LGALS3BP, ASB3, KLHL13, PCGF3, HERC6, RHOBTB1, FBXO40, FBXW5, KCNG1, SPSB3, TRIM36, ZBTB17, DTX4, ASB6, ZBTB49, MARCH9, LRSAM1, FBXO4, TRIM32, TNFAIP3, TRIM74, RCBTB2, RCBTB1, VPS41, ASB17, KCNA5, PCGF6, KCNS3, TRIM73, SPSB1, KCNA6, SOCS6, HERC4, TRIM41, TRIM7, G2E3, RNF111, RNF40, MDM4, FBXO34, FBXO10, TRIM37, RGS11, RGS6, PREB, ZBED4, RAG1, ZC3H7B, FOXD4L6, NR3C2, POGK, NR1H3, RGS7, PRDM1, STAT2, NR2C2, GTF2IRD2, DLX6, NR1I3, HP1BP3, SREBF1, NFRKB, KAT5, IRF2, TFDP3, TEAD2, C20orf194, LARP4B, ZNF74, SIM2, NR1I2, HMGA1, TBX22, BBX, CXXC1, DMRTA1, SETDB1, NFIC, SLFN11, ZNF215, TCF25, ISX, TADA2A, ATF3, THAP4, CEBPE, FOXP2, MKX, MAX, FOXM1, MAFG, TSSK3, RPS6KA5, HIPK4, MAPK4, YES1, BLK, SGK223, IRAK2, STK38, TSSK1B, PRKCE, NEK8, CAMK2G, DYRK1B, PDGFRB, PDIK1L, PRKCQ, TYRO3, RPS6KL1, PKN1, CDK3, DDR1, PRKCA, CDK18, GRK7, EPHA1, ILK, PRKCG, EPHA2, SRPK3, PIM3, TESK1, LIMK1, NUAK2, FGR, PRKCH, MAP4K1, MYLK3, RET, MAP3K9, CDK6, ALK, RPS6KB1, RPS6KC1, PRKAA2, BRAF, MAP3K5, RPS6KA2, STK38L, RPS6KA6, RPS6KA3, EPHA4, IRAK3, DMPK, CAMKV, CAMK1G, PIM2, BMX, STK32B, IGF1R, TAOK3, ROR2, PTK6, ERBB4, PASK, CDK14, MUSK, PTK2, PRKD1, STK32C, MAP4K2, IKBKE, AURKB, PTK2B, MINK1, NEK9, DAPK3, CAMKK2, AKT2, PAK6, CAMK4, PRKD2, RPS6KA1, CAMK2A, CAMK2B, CAMK2D, CLK2, CDH1, TOMM70A, IFIT1, ATF2, IQCB1, HSPA1B, GIGYF2, TUBB2B, SSBP1, TUBB, TUBB4B, DNAJA1, PDRG1, DNAJA2, TUBAL3, NOS2, AGO1, AGO2, METTL18, CAMKMT, METTL21B, METTL22, UBL4A, ILF3, FAM162A, MAP3K11, SLC12A3, PAN2, BIRC5, NPM1, SMG1, RAD52, IRF1, MMP2, DNAJA3, BAG3, PIK3C3, CAV1, RBCK1, TOMM40, LSM1, CERS2, KATNA1, KEAP1, CDKN2A, CKS2, CKS1B, AIPL1, GZMA, CAP1, MCM3, MCM5, MGEA5, PPP6R3, MAGED2, RHOBTB2, PRKACA, ADRBK1, CDK5, PRKCD, FKBP6, UNC45B, BRCA1, AURKA, CEP250, CEP57, CEP76, VHL, PSMD10, CDK1, CDC25C, PTGDS, PTGDR, HUWE1, FUS, NXF1, TRAF3IP2, MCF2, WDR76, AGO3, PCBP1, CDKL2, CDKL4, CDK13, RPS6KB2, HSPB1, AMBRA1, UNK, ATP5A1, CANX, DDOST, ATP5B, HSPE1, P4HB, SSR4, UQCRC2, PTEN, RAD51, NPHP4, HK2, NES, TERF1, TTC1, VARS, PRPF4B, U2AF2, COBLL1, SKIV2L2, ZMYM1, FAM103A1, WDR20, CRY2, ESRRB, MCM2, SNW1, CDC5L, RHOBTB3, XRCC1, EGLN1, TTK, EIF2S1, ATXN3, CRBN, UHRF1, WEE1, FLCN, FNIP2, AKT3, STK35, GBP2, ANKMY2, SLC9A1, LLGL1, RB1, FZR1, MCL1, CDKN1B, CYLD, DDX59, TRIM25, G3BP1, PRNP, SERPINB5, RRM2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MOK_HSP90AA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	HSP90AA1	P07900	DB00615	Rifabutin	Heat shock protein HSP 90-alpha	small molecule	approved\|investigational
Tgene	HSP90AA1	P07900	DB00716	Nedocromil	Heat shock protein HSP 90-alpha	small molecule	approved\|investigational

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RelatedDiseases for MOK_HSP90AA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MOK	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Tgene	HSP90AA1	C0009178	Cocaine withdrawal	1	PSYGENET
Tgene	HSP90AA1	C0011616	Contact Dermatitis	1	CTD_human
Tgene	HSP90AA1	C0019693	HIV Infections	1	CTD_human
Tgene	HSP90AA1	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	HSP90AA1	C0041696	Unipolar Depression	1	PSYGENET
Tgene	HSP90AA1	C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	1	CTD_human
Tgene	HSP90AA1	C0525045	Mood Disorders	1	PSYGENET
Tgene	HSP90AA1	C1269683	Major Depressive Disorder	1	PSYGENET
Tgene	HSP90AA1	C1458155	Mammary Neoplasms	1	CTD_human

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Fusion gene ID: 22286

FusionGeneSummary for MOK_HSP90AA1

FusionProtFeatures for MOK_HSP90AA1

FusionGeneSequence for MOK_HSP90AA1

FusionGenePPI for MOK_HSP90AA1

RelatedDrugs for MOK_HSP90AA1

RelatedDiseases for MOK_HSP90AA1