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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22277

FusionGeneSummary for MOCS3_NIPAL3

check button Fusion gene summary
Fusion gene informationFusion gene name: MOCS3_NIPAL3
Fusion gene ID: 22277
HgeneTgene
Gene symbol

MOCS3

NIPAL3

Gene ID

27304

57185

Gene namemolybdenum cofactor synthesis 3NIPA like domain containing 3
SynonymsUBA4DJ462O23.2|NPAL3
Cytomap

20q13.13

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionadenylyltransferase and sulfurtransferase MOCS3MPT synthase sulfurylaseUBA4, ubiquitin-activating enzyme E1 homologmolybdenum cofactor synthesis protein 3molybdopterin synthase sulfurylaseubiquitin-like modifier activating enzyme 4NIPA-like protein 3
Modification date2018052320180523
UniProtAcc

O95396

Q6P499

Ensembl transtripts involved in fusion geneENST00000244051, ENST00000374399, 
ENST00000003912, ENST00000358028, 
ENST00000339255, ENST00000428131, 
ENST00000488155, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MOCS3 [Title/Abstract] AND NIPAL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMOCS3

GO:0002098

tRNA wobble uridine modification

19017811

HgeneMOCS3

GO:0006777

Mo-molybdopterin cofactor biosynthetic process

15073332

HgeneMOCS3

GO:0018192

enzyme active site formation via cysteine modification to L-cysteine persulfide

15910006

HgeneMOCS3

GO:0034227

tRNA thio-modification

19017811


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1R7-01AMOCS3chr20

49578110

+NIPAL3chr1

24798588

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000244051ENST00000374399MOCS3chr20

49578110

+NIPAL3chr1

24798588

+
intron-3UTRENST00000244051ENST00000003912MOCS3chr20

49578110

+NIPAL3chr1

24798588

+
intron-intronENST00000244051ENST00000358028MOCS3chr20

49578110

+NIPAL3chr1

24798588

+
intron-intronENST00000244051ENST00000339255MOCS3chr20

49578110

+NIPAL3chr1

24798588

+
intron-intronENST00000244051ENST00000428131MOCS3chr20

49578110

+NIPAL3chr1

24798588

+
intron-intronENST00000244051ENST00000488155MOCS3chr20

49578110

+NIPAL3chr1

24798588

+

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FusionProtFeatures for MOCS3_NIPAL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOCS3

O95396

NIPAL3

Q6P499

Plays a central role in 2-thiolation of mcm(5)S(2)U attRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) andtRNA(Gln). Also essential during biosynthesis of the molybdenumcofactor. Acts by mediating the C-terminal thiocarboxylation ofsulfur carriers URM1 and MOCS2A. Its N-terminus first activatesURM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfidesulfur on the catalytic cysteine is transferred to URM1 and MOCS2Ato form thiocarboxylation (-COSH) of their C-terminus. Thereaction probably involves hydrogen sulfide that is generated fromthe persulfide intermediate and that acts as nucleophile towardsURM1 and MOCS2A. Subsequently, a transient disulfide bond isformed. Does not use thiosulfate as sulfur donor; NFS1 probablyacting as a sulfur donor for thiocarboxylation reactions.{ECO:0000255|HAMAP-Rule:MF_03049, ECO:0000269|PubMed:15073332,ECO:0000269|PubMed:19017811}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MOCS3_NIPAL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MOCS3_NIPAL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MOCS3EXOSC6, XRN2, VSX1, RSPH9, NMI, FAS, FIGF, POMK, KLC2, FBXL18, HERC4, ALX3, DYNC2H1, SACS, HSPA6, VPS16, LIN9NIPAL3ELAVL1, EDA, VPS45, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MOCS3_NIPAL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MOCS3_NIPAL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNIPAL3C0033578Prostatic Neoplasms1CTD_human