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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22274

FusionGeneSummary for MOCS1_LEMD3

check button Fusion gene summary
Fusion gene informationFusion gene name: MOCS1_LEMD3
Fusion gene ID: 22274
HgeneTgene
Gene symbol

MOCS1

LEMD3

Gene ID

4337

23592

Gene namemolybdenum cofactor synthesis 1LEM domain containing 3
SynonymsMIG11|MOCOD|MOCS1A|MOCS1BMAN1
Cytomap

6p21.2

12q14.3

Type of geneprotein-codingprotein-coding
Descriptionmolybdenum cofactor biosynthesis protein 1MOCS1A enzymecell migration-inducing gene 11 proteinmolybdenum cofactor biosynthesis protein Amolybdenum cofactor synthesis-step 1 protein A-Binner nuclear membrane protein Man1LEM domain-containing protein 3LEMD3/MKX fusionintegral inner nuclear membrane protein
Modification date2018052220180523
UniProtAcc

Q9NZB8

Q9Y2U8

Ensembl transtripts involved in fusion geneENST00000373186, ENST00000373175, 
ENST00000308559, ENST00000373188, 
ENST00000373195, ENST00000340692, 
ENST00000425303, ENST00000432280, 
ENST00000308330, ENST00000541171, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 4=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MOCS1 [Title/Abstract] AND LEMD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLEMD3

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

15647271

TgeneLEMD3

GO:0030514

negative regulation of BMP signaling pathway

15647271

TgeneLEMD3

GO:0032926

negative regulation of activin receptor signaling pathway

15647271


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-29-A5NZ-01AMOCS1chr6

39893422

-LEMD3chr12

65632282

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373186ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373186ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000373175ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373175ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000308559ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000308559ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000373188ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373188ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000373195ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000373195ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000340692ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000340692ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000425303ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000425303ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+
Frame-shiftENST00000432280ENST00000308330MOCS1chr6

39893422

-LEMD3chr12

65632282

+
5CDS-intronENST00000432280ENST00000541171MOCS1chr6

39893422

-LEMD3chr12

65632282

+

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FusionProtFeatures for MOCS1_LEMD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOCS1

Q9NZB8

LEMD3

Q9Y2U8

Can function as a specific repressor of TGF-beta,activin, and BMP signaling through its interaction with the R-SMADproteins. Antagonizes TGF-beta-induced cell proliferation arrest.{ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313635_640565912Compositional biasNote=Poly-Leu
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313659_662565912Compositional biasNote=Poly-Glu
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313707_726565912DNA binding.
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313628_648565912TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMOCS1chr6:39893422chr12:65632282ENST00000308559-3101_383139621RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000308559-310317_319139621RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000308559-310414_636139621RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000340692-3111_383139637RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000340692-311317_319139637RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000340692-311414_636139637RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373175-3111_3831101277RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373175-311317_3191101277RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373175-311414_6361101277RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373186-2101_3831391206RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373186-210317_3191391206RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373186-210414_6361391206RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373188-3111_383139965RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373188-311317_319139965RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373188-311414_636139965RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373195-291_38352534RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373195-29317_31952534RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000373195-29414_63652534RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000425303-2101_383139637RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000425303-210317_319139637RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000425303-210414_636139637RegionNote=Molybdenum cofactor biosynthesis protein C
HgeneMOCS1chr6:39893422chr12:65632282ENST00000432280-3101_383110357RegionNote=Molybdenum cofactor biosynthesis protein A
HgeneMOCS1chr6:39893422chr12:65632282ENST00000432280-310317_319110357RegionGTP binding
HgeneMOCS1chr6:39893422chr12:65632282ENST00000432280-310414_636110357RegionNote=Molybdenum cofactor biosynthesis protein C
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313155_158565912Compositional biasNote=Poly-Gly
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313265_268565912Compositional biasNote=Poly-Asp
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313312_315565912Compositional biasNote=Poly-Gly
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313322_325565912Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313337_340565912Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+31365_70565912Compositional biasNote=Poly-Asn
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+31372_87565912Compositional biasNote=Ala-rich
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+31382_87565912Compositional biasNote=Poly-Ala
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+3136_50565912DomainLEM
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313475_495565912TransmembraneHelical


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FusionGeneSequence for MOCS1_LEMD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MOCS1_ENST00000373186_chr6_39893422_-_LEMD3_ENST00000308330_chr12_65632282_+_486aa
MWKSWKLRTDVRVREGAGGSPCASSQPGSRGPCFLPGLSSQEVSRRRQFLREHAAPFSAFLTDSFGRQHSYLRISLTEKCNLRCQYCMPE
EGVPLTPKANLLTTEEILTLARLFVKEGIDKIRLTGGEPLIRPDVVDIVGFRSXIXRYIXHFIAVDLRKWKRCWNKVCWFWPXGRIDKYN
XCAVFTVHKTTDVFLVSFSTCFCYCNSQIIVVMLRCSDGLCRSALHEISMDKRRGGNKADVXYGGKDYRCFTKSXXSLPGKQRFTTLHAY
STCTRFLNTASXQEKNEESLGXSCXLPCCXXVXSSHGNTKNRWCRFSGLAVDPAFCILXQNISYTFXSMARSSISFRXKKFTTKXFDTVS
KDSEYVXSRYGNRGSVAFGNSRSNFRKMQXXXWHCSHCSRQKFTXGLCICXMSVSRICWKGFXSIAWLLVXWEIGYSKIFTTRXIPPSLS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MOCS1_ENST00000373186_chr6_39893422_-_LEMD3_ENST00000308330_chr12_65632282_+_1459nt
ATGTGGAAGAGTTGGAAGCTCCGCACAGATGTCAGAGTAAGGGAGGGGGCAGGCGGTTCTCCTTGTGCCTCTTCCCAGCCCGGTAGCAGG
GGCCCATGCTTCCTCCCTGGTCTGTCCTCGCAGGAGGTGTCCAGGCGGAGGCAGTTCCTGCGGGAGCATGCGGCCCCCTTCTCCGCCTTC
CTCACAGACAGCTTCGGCCGGCAGCACAGCTACCTGCGGATCTCCCTCACAGAGAAGTGCAACCTCAGATGTCAGTACTGCATGCCCGAG
GAGGGGGTCCCGCTGACCCCCAAAGCCAACCTGCTGACCACAGAGGAGATCCTGACCCTCGCCCGGCTCTTTGTGAAGGAAGGCATCGAC
AAGATCCGGCTCACAGGTGGAGAGCCGCTTATCCGGCCGGACGTGGTGGACATTGTGGGATTTAGGTCCTGAATATGAAGGTATATTTAA
CACTTCATTGCAGTGGATCTTAGAAAATGGAAAAGATGTTGGAATAAGGTGTGTTGGTTTTGGCCCTGAGGAAGAATTGACAAATATAAC
TGATGTGCAGTTTTTACAGTCCACAAGACCACTGATGTCTTTTTGGTGTCGTTTTCGACGTGCTTTTGTTACTGTAACTCACAGATTATT
GTTGTTATGCTTAGGTGTAGTGATGGTTTGTGTCGTTCTGCGTTACATGAAATATCGATGGACAAAAGAAGAGGAGGAAACAAGGCAGAT
GTATGATATGGTGGTAAAGATTATAGATGTTTTACGAAGTCATAATGAAGCCTGCCAGGAAAACAAAGATTTACAACCTTACATGCCTAT
TCCACATGTACGCGATTCCTTAATACAGCCTCATGACAGGAAAAAAATGAAGAAAGTCTGGGATAGAGCTGTTGACTTCCTTGCTGCTAA
TGAGTCTAGAGTTCGCACGGAAACACGAAGAATAGGTGGTGCAGATTTTCTGGTTTGGCGGTGGATCCAGCCTTCTGCATCCTGTGACAA
AATATTAGTTATACCTTCTAAAGTATGGCAAGGTCAAGCATTTCATTTAGATAGAAGAAATTCACCACCAAATAGTTTGACACCGTGTCT
AAAGATTCGGAATATGTTTGATCCCGTTATGGAAATAGGGGATCAGTGGCATTTGGCAATTCAAGAAGCAATTTTAGAAAAATGCAGTGA
TAATGATGGCATTGTTCACATTGCAGTAGACAAAAATTCACGTGAGGGTTGTGTATATGTTAAATGTCTGTCTCCAGAATATGCTGGAAA
GGCTTTTAAAGCATTGCATGGCTCTTGGTTTGATGGGAAATTGGTTACAGTAAAATATTTACGACTAGATAGATACCACCATCGCTTTCC
CCAGGCTCTCACTTCCAACACTCCATTGAAGCCATCAAATAAACATATGAACTCCATGTCTCATCTTCGTCTTCGGACTGGCCTAACCAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MOCS1_ENST00000373186_chr6_39893422_-_LEMD3_ENST00000308330_chr12_65632282_+_3599nt
GCCAGAAATCTTCCCAGTAGAGATCACCATCCGCCCCCGACCCCCAAGCTGAATACTTAAGGGGTGGGTCCTTCCCATCAAGCTGATTTC
TCAACGAGAGGGACAATCCCAGCTTCCCCAACATTGCAGAGCCCAAACATGTGGAAGAGTTGGAAGCTCCGCACAGATGTCAGAGTAAGG
GAGGGGGCAGGCGGTTCTCCTTGTGCCTCTTCCCAGCCCGGTAGCAGGGGCCCATGCTTCCTCCCTGGTCTGTCCTCGCAGGAGGTGTCC
AGGCGGAGGCAGTTCCTGCGGGAGCATGCGGCCCCCTTCTCCGCCTTCCTCACAGACAGCTTCGGCCGGCAGCACAGCTACCTGCGGATC
TCCCTCACAGAGAAGTGCAACCTCAGATGTCAGTACTGCATGCCCGAGGAGGGGGTCCCGCTGACCCCCAAAGCCAACCTGCTGACCACA
GAGGAGATCCTGACCCTCGCCCGGCTCTTTGTGAAGGAAGGCATCGACAAGATCCGGCTCACAGGTGGAGAGCCGCTTATCCGGCCGGAC
GTGGTGGACATTGTGGGATTTAGGTCCTGAATATGAAGGTATATTTAACACTTCATTGCAGTGGATCTTAGAAAATGGAAAAGATGTTGG
AATAAGGTGTGTTGGTTTTGGCCCTGAGGAAGAATTGACAAATATAACTGATGTGCAGTTTTTACAGTCCACAAGACCACTGATGTCTTT
TTGGTGTCGTTTTCGACGTGCTTTTGTTACTGTAACTCACAGATTATTGTTGTTATGCTTAGGTGTAGTGATGGTTTGTGTCGTTCTGCG
TTACATGAAATATCGATGGACAAAAGAAGAGGAGGAAACAAGGCAGATGTATGATATGGTGGTAAAGATTATAGATGTTTTACGAAGTCA
TAATGAAGCCTGCCAGGAAAACAAAGATTTACAACCTTACATGCCTATTCCACATGTACGCGATTCCTTAATACAGCCTCATGACAGGAA
AAAAATGAAGAAAGTCTGGGATAGAGCTGTTGACTTCCTTGCTGCTAATGAGTCTAGAGTTCGCACGGAAACACGAAGAATAGGTGGTGC
AGATTTTCTGGTTTGGCGGTGGATCCAGCCTTCTGCATCCTGTGACAAAATATTAGTTATACCTTCTAAAGTATGGCAAGGTCAAGCATT
TCATTTAGATAGAAGAAATTCACCACCAAATAGTTTGACACCGTGTCTAAAGATTCGGAATATGTTTGATCCCGTTATGGAAATAGGGGA
TCAGTGGCATTTGGCAATTCAAGAAGCAATTTTAGAAAAATGCAGTGATAATGATGGCATTGTTCACATTGCAGTAGACAAAAATTCACG
TGAGGGTTGTGTATATGTTAAATGTCTGTCTCCAGAATATGCTGGAAAGGCTTTTAAAGCATTGCATGGCTCTTGGTTTGATGGGAAATT
GGTTACAGTAAAATATTTACGACTAGATAGATACCACCATCGCTTTCCCCAGGCTCTCACTTCCAACACTCCATTGAAGCCATCAAATAA
ACATATGAACTCCATGTCTCATCTTCGTCTTCGGACTGGCCTAACCAATTCTCAAGGAAGTTCCTGAAAAGATTTTCTTCCATTTCTAAG
ACTGTTATTTACAATAGGAAAATTCCTGTTTGGCTTTTTGTCTTCCTTTTTAAATGCTTTTTGTATGTAATATTTTTATTGATGAATACA
TCTCTGAACGTTCCAGAAGTCTTAAGGTTCCAAAGGGATTTAGCAGTGAGGCAGCAATGCTGAGTAGGTAGGATAATTATTTCATTCAGT
TTTTGGAGCTCAGTTAAGCCAATACATTTAAAGTTTTGCATGAGGAACACTGACTTTATTAAGCATTTTCAGATGTGGTGGTTGTATTTT
TGCCCCAAGAAGTGTTTGGATAACCACACAAAAGCATGATGAAAAGGCTTCTTGTAGTCCCATAATTTCTTGTGAACTAATGTTGTGAAT
TTTTGTATACAGTCACCTGCATAGTTCCTACAGGCTAATGTGGTAAAACTGTTGATTTCCCAATTTAACCTTAGGTTTCTGTTGCTTATA
AGCGATTCATTTGCTACGGCTGGAATATGGGAAAATTAATTTGGGCTTAGTGGTTACAAATATGTGTAAGTGGATGTATATGTACTTAAA
CTGGCTTTGTATATATGTATAAATGCTGGTGGTGGTGAAAGTAGTCTTGTTTTATGAGGATGTCTGCATTAAAGCAGTAAAATAAGCTTT
CCATTTTATTCATAATCTAATGTGTGTGTATATATGTATGTGTGTATGTGTGTGTATATATAGATGTATATATATACACACACAGAGATA
TATACATATGGCTGTACTTTTGCATAGATCAAACAGCCAAACACCTGGAAGTATTAGATACAAGTTTAAAATATCTTTTATAGGTTTTAT
ATAAAAATGTCTGAGTATGATTTTGTGTGAAAGTTCTGATACCAGTTGTAATAGAGTCAAATTTATGTGAGCAATAAAGAAGAAATTGGC
AGATATTGGAAAAATATTTTGTGAAAAGCTGTATTTATTATAAATACTAGGGCCATGACATAGTACCATTGGGGTTAAGTCATTTTCCCA
ATCTATTTATAATTTAATGATATGTTAGTGCCTCTGTTATATGTCAAGTTTAAAGCAGGGCACATTGTTGCAGCAAAATGTGTATTTGAC
AAATTATACTTGCAATTTTGGGTCATGAAAGTTTGCAATATAGTAAATGCACGATTGACTGTTGCTTTGTGCCTCAGTATTTAATTTGTT
TCAGTAAACTTACTTTATTACTGTTTATGATTTCAGATAAAAATAGTTGCTGAGTAAATTTTACTTGTAATCTACAATTGGCTTTTTAAA
AATAACCTGTTGATATATAATTGTCAGTCCAAATGAATATGTGAAACAGCTGGAATTGTACAAATTTTGGTTGTATTTAAAGCTCAGTTT
CCTTTTTGTTTTATTGTATGCGTTGGGTTTGCAGCATGAACTTGCACAGATAATGCACGTTTTCTGGTTAAGTAAACATGATGCACACTA
TTCTGTAACAGAAAGCCCTATTGTGCCTTACCTGTGTGCTTTTGTGGGCACCTTGTTTATGAAGAATAAAAAATGATTTGTTATCTGAAG
AGAATAAATTTTAAATTCTCAGTTTATGTCTCAGATGCTAACGTGTGAAAATATAAATATATATAATATATAAAGTAACCAGTCTTCCTG
TATTTTATGTGCATCATAGTGATTTATCTGAGCTTAGTGACCCCCATCTTGTAACCTGTTGCAAGAGTGAATGTAAAAAATAGTTGTGGC
ATTTTAAAAGGTCGCCTTTGATGCAGATGCATCTTTTTCTTGCTTCTAAAACATATTTCATGTAAACATTGTACATTTATTATTGTAATA
TATACTATTATGCAGCTTATTTTACCTGAAACTGTTAAGCCGACCAAGATCCCTCCCTGCAAGACAGATGGGAATGTGTATAATAACTAG


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FusionGenePPI for MOCS1_LEMD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MOCS1PIN1, RAB17, UROS, KLHDC3, OXLD1, FBXW7, RAB8B, TINAG, CCDC120, BPNT1, FCRL4LEMD3SMAD2, SMAD3, CDV3, DUT, SMAD9, SMAD1, LMNA, PYCARD, SPINT2, SRPRB, NRG1, SLAMF7, TMEM171, TEX29, SYNE4, VSIG2, B3GAT3, SGCA, WBP1, LPAR1, HTR3C, NTRK1, NUP160, NUP35, HIST1H2BG, B9D2, TCTN2, TCTN3, TMEM17, TMEM216, NANOG, POU5F1, CTDNEP1, AOC2, KIAA1467, MME, IPPK, ZNRF4, TRHDE, LAMP1, CDHR5, SYT12, CD44, PCDHGB1, LRRC32, PCDHGB4, TRIM25, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneLEMD3chr6:39893422chr12:65632282ENST00000308330+313699_911565912SMAD1%2C SMAD2%2C SMAD3 and SMAD5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MOCS1_LEMD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MOCS1_LEMD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMOCS1C1854988Molybdenum Cofactor Deficiency, Complementation Group A3ORPHANET;UNIPROT