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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22259

FusionGeneSummary for MOB2_WIPI1

check button Fusion gene summary
Fusion gene informationFusion gene name: MOB2_WIPI1
Fusion gene ID: 22259
HgeneTgene
Gene symbol

MOB2

WIPI1

Gene ID

81532

55062

Gene nameMOB kinase activator 2WD repeat domain, phosphoinositide interacting 1
SynonymsHCCA2ATG18|ATG18A|WIPI49
Cytomap

11p15.5

17q24.2

Type of geneprotein-codingprotein-coding
DescriptionMOB kinase activator 2MOB2 Mps One Binder homologMps one binder kinase activator-like 2WD repeat domain phosphoinositide-interacting protein 1WIPI-1 alphaatg18 protein homolog
Modification date2018051920180523
UniProtAcc

Q70IA6

Q5MNZ9

Ensembl transtripts involved in fusion geneENST00000329957, ENST00000526462, 
ENST00000262139, ENST00000589459, 
ENST00000546360, 
Fusion gene scores* DoF score9 X 12 X 2=2165 X 5 X 2=50
# samples 125
** MAII scorelog2(12/216*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: MOB2 [Title/Abstract] AND WIPI1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWIPI1

GO:0048203

vesicle targeting, trans-Golgi to endosome

15020712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF946607MOB2chr11

1765145

+WIPI1chr17

66441826

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000329957ENST00000262139MOB2chr11

1765145

+WIPI1chr17

66441826

+
intron-intronENST00000329957ENST00000589459MOB2chr11

1765145

+WIPI1chr17

66441826

+
intron-intronENST00000329957ENST00000546360MOB2chr11

1765145

+WIPI1chr17

66441826

+
intron-intronENST00000526462ENST00000262139MOB2chr11

1765145

+WIPI1chr17

66441826

+
intron-intronENST00000526462ENST00000589459MOB2chr11

1765145

+WIPI1chr17

66441826

+
intron-intronENST00000526462ENST00000546360MOB2chr11

1765145

+WIPI1chr17

66441826

+

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FusionProtFeatures for MOB2_WIPI1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MOB2

Q70IA6

WIPI1

Q5MNZ9

Stimulates the autophosphorylation and kinase activityof STK38 and STK38L. {ECO:0000269|PubMed:15067004}. Plays an important role in autophagy and in particularstarvation- and calcium-mediated autophagy, as well as inmitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complexand LC3, and downstream of the ULK1 and PI3-kinase complexes.Involved in xenophagy of Staphylococcus aureus. Invading S.aureuscells become entrapped in autophagosome-like WIPI1 positivevesicles targeted for lysosomal degradation. Plays also a distinctrole in controlling the transcription of melanogenic enzymes andmelanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteinsinvolved in the mannose-6-phosphate receptor (MPR) recyclingpathway. {ECO:0000269|PubMed:15020712,ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074,ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694,ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830,ECO:0000269|PubMed:23088497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MOB2_WIPI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MOB2_WIPI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MOB2_WIPI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MOB2_WIPI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWIPI1C0023794Lipoidosis3CTD_human