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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22242

FusionGeneSummary for MNT_CDK19

check button Fusion gene summary
Fusion gene informationFusion gene name: MNT_CDK19
Fusion gene ID: 22242
HgeneTgene
Gene symbol

MNT

CDK19

Gene ID

4335

23097

Gene nameMAX network transcriptional repressorcyclin dependent kinase 19
SynonymsMAD6|MXD6|ROX|bHLHd3CDC2L6|CDK11|bA346C16.3
Cytomap

17p13.3

6q21

Type of geneprotein-codingprotein-coding
Descriptionmax-binding protein MNTMAX binding proteinMNT, MAX dimerization proteinMax-interacting proteinclass D basic helix-loop-helix protein 3myc antagonist MNTcyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin dependent kinase 19 variant 2cyclin-dep
Modification date2018051920180523
UniProtAcc

Q99583

Q9BWU1

Ensembl transtripts involved in fusion geneENST00000174618, ENST00000575374, 
ENST00000575394, 
ENST00000368911, 
ENST00000323817, ENST00000413605, 
ENST00000497709, 
Fusion gene scores* DoF score3 X 3 X 1=910 X 9 X 5=450
# samples 412
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(12/450*10)=-1.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MNT [Title/Abstract] AND CDK19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMNT

GO:0000122

negative regulation of transcription by RNA polymerase II

9184233


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI244697MNTchr17

2292774

-CDK19chr6

111043990

-
ChiTaRS3.1BF591193MNTchr17

2292774

-CDK19chr6

111043990

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000174618ENST00000368911MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000174618ENST00000323817MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000174618ENST00000413605MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000174618ENST00000497709MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575374ENST00000368911MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575374ENST00000323817MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575374ENST00000413605MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575374ENST00000497709MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575394ENST00000368911MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575394ENST00000323817MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575394ENST00000413605MNTchr17

2292774

-CDK19chr6

111043990

-
intron-intronENST00000575394ENST00000497709MNTchr17

2292774

-CDK19chr6

111043990

-

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FusionProtFeatures for MNT_CDK19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MNT

Q99583

CDK19

Q9BWU1

Binds DNA as a heterodimer with MAX and repressestranscription. Binds to the canonical E box sequence 5'-CACGTG-3'and, with higher affinity, to 5'-CACGCG-3'.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MNT_CDK19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MNT_CDK19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MNT_CDK19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MNT_CDK19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMNTC0008925Cleft Palate1CTD_human
HgeneMNTC0376634Craniofacial Abnormalities1CTD_human
HgeneMNTC1955870Classical Lissencephalies and Subcortical Band Heterotopias1CTD_human