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Fusion gene ID: 22230 |
FusionGeneSummary for MMP9_UTRN |
Fusion gene summary |
Fusion gene information | Fusion gene name: MMP9_UTRN | Fusion gene ID: 22230 | Hgene | Tgene | Gene symbol | MMP9 | UTRN | Gene ID | 4318 | 7402 |
Gene name | matrix metallopeptidase 9 | utrophin | |
Synonyms | CLG4B|GELB|MANDP2|MMP-9 | DMDL|DRP|DRP1 | |
Cytomap | 20q13.12 | 6q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | matrix metalloproteinase-9macrophage gelatinasematrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)type V collagenase | utrophinDRP-1dystrophin-related protein 1 | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P14780 | P46939 | |
Ensembl transtripts involved in fusion gene | ENST00000372330, | ENST00000367545, ENST00000367526, ENST00000480333, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 33 X 9 X 9=2673 |
# samples | 1 | 33 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(33/2673*10)=-3.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MMP9 [Title/Abstract] AND UTRN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MMP9 | GO:0006508 | proteolysis | 2551898|15863497|19022250|24164424 |
Hgene | MMP9 | GO:0034614 | cellular response to reactive oxygen species | 26514923 |
Hgene | MMP9 | GO:0043388 | positive regulation of DNA binding | 22984561 |
Hgene | MMP9 | GO:0071276 | cellular response to cadmium ion | 26514923 |
Hgene | MMP9 | GO:1900122 | positive regulation of receptor binding | 24164424 |
Hgene | MMP9 | GO:2001258 | negative regulation of cation channel activity | 24164424 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CR-7382-01A | MMP9 | chr20 | 44645199 | + | UTRN | chr6 | 144665237 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000372330 | ENST00000367545 | MMP9 | chr20 | 44645199 | + | UTRN | chr6 | 144665237 | + |
5CDS-intron | ENST00000372330 | ENST00000367526 | MMP9 | chr20 | 44645199 | + | UTRN | chr6 | 144665237 | + |
5CDS-intron | ENST00000372330 | ENST00000480333 | MMP9 | chr20 | 44645199 | + | UTRN | chr6 | 144665237 | + |
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FusionProtFeatures for MMP9_UTRN |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MMP9 | UTRN |
May play an essential role in local proteolysis of theextracellular matrix and in leukocyte migration. Could play a rolein bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leubond. Cleaves type IV and type V collagen into large C-terminalthree quarter fragments and shorter N-terminal one quarterfragments. Degrades fibronectin but not laminin or Pz-peptide.{ECO:0000269|PubMed:1480034}. | May play a role in anchoring the cytoskeleton to theplasma membrane. {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MMP9_UTRN |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MMP9_UTRN |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MMP9 | CXCL5, CXCL6, TGFB1, THBS1, THBS2, CLU, COL12A1, TIMP1, COL2A1, COL14A1, COL5A1, COL6A2, COL4A1, FN1, COL4A2, COL6A1, COL18A1, SCARA3 | UTRN | SNTA1, SNTB2, DAG1, UTRN, DTNA, PGM5, USP21, MARK2, PIK3CG, TERF1, TERF2, MME, DISC1, SIRT7, THOC1, RRP9, THOC2, THOC6, THOC5, UBE2D1, ZC3H15, XPO4, THOC3, UBE3C, PTPN12, NPM1, ADRA1D, LATS2, SAV1, OBSL1, CCDC8, L3HYPDH, IER2, USP7, CALM1, PTEN, MED4, TMEM17, PDK3, PI4KB, TTK, RBM8A, MCM2, ATOH1, CDH1, TENC1, TNS1, TNS3, SNTG2, NDEL1, DMD, CPNE5, FAM167A, RHPN1, PTRF, VHL, CPNE4, TTC30B, FAM189B, PHF19, TES |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MMP9_UTRN |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MMP9 | P14780 | DB01197 | Captopril | Matrix metalloproteinase-9 | small molecule | approved |
Hgene | MMP9 | P14780 | DB01017 | Minocycline | Matrix metalloproteinase-9 | small molecule | approved|investigational |
Hgene | MMP9 | P14780 | DB01296 | Glucosamine | Matrix metalloproteinase-9 | small molecule | approved|investigational |
Hgene | MMP9 | P14780 | DB01593 | Zinc | Matrix metalloproteinase-9 | small molecule | approved|investigational |
Hgene | MMP9 | P14780 | DB00143 | Glutathione | Matrix metalloproteinase-9 | small molecule | approved|investigational|nutraceutical |
Tgene | UTRN | P46939 | DB01593 | Zinc | Utrophin | small molecule | approved|investigational |
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RelatedDiseases for MMP9_UTRN |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MMP9 | C0027626 | Neoplasm Invasiveness | 7 | CTD_human |
Hgene | MMP9 | C0027627 | Neoplasm Metastasis | 5 | CTD_human |
Hgene | MMP9 | C2937358 | Cerebral Hemorrhage | 5 | CTD_human |
Hgene | MMP9 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Hgene | MMP9 | C0007621 | Neoplastic Cell Transformation | 3 | CTD_human |
Hgene | MMP9 | C0004096 | Asthma | 2 | CTD_human |
Hgene | MMP9 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Hgene | MMP9 | C0006663 | Calcinosis | 2 | CTD_human |
Hgene | MMP9 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
Hgene | MMP9 | C0021368 | Inflammation | 2 | CTD_human |
Hgene | MMP9 | C0023895 | Liver diseases | 2 | CTD_human |
Hgene | MMP9 | C0027051 | Myocardial Infarction | 2 | CTD_human |
Hgene | MMP9 | C0031099 | Periodontitis | 2 | CTD_human |
Hgene | MMP9 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | MMP9 | C0003486 | Aortic Aneurysm | 1 | CTD_human |
Hgene | MMP9 | C0003493 | Aortic Diseases | 1 | CTD_human |
Hgene | MMP9 | C0003496 | Aortic Rupture | 1 | CTD_human |
Hgene | MMP9 | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | MMP9 | C0005967 | Bone neoplasms | 1 | CTD_human |
Hgene | MMP9 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | MMP9 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | MMP9 | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | MMP9 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
Hgene | MMP9 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | MMP9 | C0011882 | Diabetic Neuropathies | 1 | CTD_human |
Hgene | MMP9 | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | MMP9 | C0020507 | Hyperplasia | 1 | CTD_human |
Hgene | MMP9 | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | MMP9 | C0023176 | Lead Poisoning | 1 | CTD_human |
Hgene | MMP9 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | MMP9 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
Hgene | MMP9 | C0024143 | Lupus Nephritis | 1 | CTD_human |
Hgene | MMP9 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | MMP9 | C0024796 | Marfan Syndrome | 1 | CTD_human |
Hgene | MMP9 | C0026552 | Morphine Dependence | 1 | CTD_human |
Hgene | MMP9 | C0026766 | Multiple Organ Failure | 1 | CTD_human |
Hgene | MMP9 | C0028754 | Obesity | 1 | CTD_human |
Hgene | MMP9 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
Hgene | MMP9 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Hgene | MMP9 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | MMP9 | C0034067 | Pulmonary Emphysema | 1 | CTD_human |
Hgene | MMP9 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Hgene | MMP9 | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | MMP9 | C0035309 | Retinal Diseases | 1 | CTD_human |
Hgene | MMP9 | C0037286 | Skin Neoplasms | 1 | CTD_human |
Hgene | MMP9 | C0038358 | Gastric ulcer | 1 | CTD_human |
Hgene | MMP9 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Hgene | MMP9 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
Hgene | MMP9 | C0151526 | Premature Birth | 1 | CTD_human |
Hgene | MMP9 | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human |
Hgene | MMP9 | C0162872 | Aortic Aneurysm, Thoracic | 1 | CTD_human |
Hgene | MMP9 | C0243026 | Sepsis | 1 | CTD_human |
Hgene | MMP9 | C0338831 | Manic | 1 | PSYGENET |
Hgene | MMP9 | C0340288 | Stable angina | 1 | CTD_human |
Hgene | MMP9 | C0432291 | Mandibuloacral dysostosis | 1 | CTD_human |
Hgene | MMP9 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Hgene | MMP9 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | MMP9 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | MMP9 | C1527311 | Brain Edema | 1 | CTD_human |
Hgene | MMP9 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | MMP9 | C2936380 | Neointima | 1 | CTD_human |