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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22229

FusionGeneSummary for MMP7_MMP7

check button Fusion gene summary
Fusion gene informationFusion gene name: MMP7_MMP7
Fusion gene ID: 22229
HgeneTgene
Gene symbol

MMP7

MMP7

Gene ID

4316

4316

Gene namematrix metallopeptidase 7matrix metallopeptidase 7
SynonymsMMP-7|MPSL1|PUMP-1MMP-7|MPSL1|PUMP-1
Cytomap

11q22.2

11q22.2

Type of geneprotein-codingprotein-coding
Descriptionmatrilysinmatrinmatrix metallopeptidase 7 (matrilysin, uterine)matrix metalloproteinase 7 (matrilysin, uterine)matrix metalloproteinase-7pump-1 proteaseuterine matrilysinuterine metalloproteinasematrilysinmatrinmatrix metallopeptidase 7 (matrilysin, uterine)matrix metalloproteinase 7 (matrilysin, uterine)matrix metalloproteinase-7pump-1 proteaseuterine matrilysinuterine metalloproteinase
Modification date2018052320180523
UniProtAcc

P09237

P09237

Ensembl transtripts involved in fusion geneENST00000260227, ENST00000260227, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: MMP7 [Title/Abstract] AND MMP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMMP7

GO:0006508

proteolysis

15297466|26482249

TgeneMMP7

GO:0006508

proteolysis

15297466|26482249


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF081442MMP7chr11

102398354

+MMP7chr11

102401480

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000260227ENST00000260227MMP7chr11

102398354

+MMP7chr11

102401480

-

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FusionProtFeatures for MMP7_MMP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MMP7

P09237

MMP7

P09237

Degrades casein, gelatins of types I, III, IV, and V,and fibronectin. Activates procollagenase.{ECO:0000269|PubMed:2550050}. Degrades casein, gelatins of types I, III, IV, and V,and fibronectin. Activates procollagenase.{ECO:0000269|PubMed:2550050}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MMP7_MMP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MMP7_MMP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MMP7_MMP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MMP7_MMP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMMP7C0000786Spontaneous abortion1CTD_human
HgeneMMP7C0009375Colonic Neoplasms1CTD_human
HgeneMMP7C0038356Stomach Neoplasms1CTD_human
TgeneMMP7C0000786Spontaneous abortion1CTD_human
TgeneMMP7C0009375Colonic Neoplasms1CTD_human
TgeneMMP7C0038356Stomach Neoplasms1CTD_human