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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22225

FusionGeneSummary for MMP2_HNRNPA2B1

check button Fusion gene summary
Fusion gene informationFusion gene name: MMP2_HNRNPA2B1
Fusion gene ID: 22225
HgeneTgene
Gene symbol

MMP2

HNRNPA2B1

Gene ID

4313

3181

Gene namematrix metallopeptidase 2heterogeneous nuclear ribonucleoprotein A2/B1
SynonymsCLG4|CLG4A|MMP-2|MMP-II|MONA|TBE-1HNRNPA2|HNRNPB1|HNRPA2|HNRPA2B1|HNRPB1|IBMPFD2|RNPA2|SNRPB1
Cytomap

16q12.2

7p15.2

Type of geneprotein-codingprotein-coding
Description72 kDa type IV collagenasecollagenase type IV-Amatrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)matrix metalloproteinase-2matrix metalloproteinase-IIneutrophil gelatinaseheterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1/MYC fusionhnRNP A2 / hnRNP B1nuclear ribonucleoprotein particle A2 protein
Modification date2018051920180523
UniProtAcc

P08253

P22626

Ensembl transtripts involved in fusion geneENST00000570308, ENST00000219070, 
ENST00000543485, ENST00000437642, 
ENST00000476233, ENST00000354667, 
ENST00000356674, 
Fusion gene scores* DoF score4 X 4 X 1=1615 X 19 X 2=570
# samples 521
** MAII scorelog2(5/16*10)=1.64385618977472
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(21/570*10)=-1.44057259138598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MMP2 [Title/Abstract] AND HNRNPA2B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMMP2

GO:0006508

proteolysis

15863497

TgeneHNRNPA2B1

GO:0006397

mRNA processing

2557628

TgeneHNRNPA2B1

GO:0006406

mRNA export from nucleus

10567417

TgeneHNRNPA2B1

GO:0031053

primary miRNA processing

26321680

TgeneHNRNPA2B1

GO:0050658

RNA transport

17004321

TgeneHNRNPA2B1

GO:1990428

miRNA transport

24356509


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG501102MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000570308ENST00000476233MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
3UTR-intronENST00000570308ENST00000354667MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
3UTR-intronENST00000570308ENST00000356674MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
3UTR-intronENST00000219070ENST00000476233MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
3UTR-intronENST00000219070ENST00000354667MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
3UTR-intronENST00000219070ENST00000356674MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
intron-intronENST00000543485ENST00000476233MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
intron-intronENST00000543485ENST00000354667MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
intron-intronENST00000543485ENST00000356674MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
intron-intronENST00000437642ENST00000476233MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
intron-intronENST00000437642ENST00000354667MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-
intron-intronENST00000437642ENST00000356674MMP2chr16

55539722

+HNRNPA2B1chr7

26233310

-

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FusionProtFeatures for MMP2_HNRNPA2B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MMP2

P08253

HNRNPA2B1

P22626

Ubiquitinous metalloproteinase that is involved indiverse functions such as remodeling of the vasculature,angiogenesis, tissue repair, tumor invasion, inflammation, andatherosclerotic plaque rupture. As well as degrading extracellularmatrix proteins, can also act on several nonmatrix proteins suchas big endothelial 1 and beta-type CGRP promotingvasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appearsto have a role in myocardial cell death pathways. Contributes tomyocardial oxidative stress by regulating the activity ofGSK3beta. Cleaves GSK3beta in vitro. Involved in the formation ofthe fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2,posseses anti-angiogenic and anti-tumor properties and inhibitscell migration and cell adhesion to FGF2 and vitronectin. Ligandfor integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA andinitiates a primary innate immune response by inducingmitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. Heterogeneous nuclear ribonucleoprotein (hnRNP) thatassociates with nascent pre-mRNAs, packaging them into hnRNPparticles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilizethe transcripts and minimize tangling and knotting. Packagingplays a role in various processes such as transcription, pre-mRNAprocessing, RNA nuclear export, subcellular location, mRNAtranslation and stability of mature mRNAs (PubMed:19099192). FormshnRNP particles with at least 20 other different hnRNP andheterogeneous nuclear RNA in the nucleus. Involved in transport ofspecific mRNAs to the cytoplasm in oligodendrocytes and neurons:acts by specifically recognizing and binding the A2RE (21nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11nucleotide oligonucleotide) sequence motifs present on some mRNAs,and promotes their transport to the cytoplasm (PubMed:10567417).Specifically binds single-stranded telomeric DNA sequences,protecting telomeric DNA repeat against endonuclease digestion (Bysimilarity). Also binds other RNA molecules, such as primary miRNA(pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine(m6A) mark by specifically recognizing and binding a subset ofnuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8to pri-miRNA transcripts (PubMed:26321680). Involved in miRNAsorting into exosomes following sumoylation, possibly by binding(m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulatorof efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).{ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417,ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680,ECO:0000303|PubMed:19099192}. (Microbial infection) Involved in the transport of HIV-1genomic RNA out of the nucleus, to the microtubule organizingcenter (MTOC), and then from the MTOC to the cytoplasm: acts byspecifically recognizing and binding the A2RE (21 nucleotide hnRNPA2 response element) sequence motifs present on HIV-1 genomic RNA,and promotes its transport. {ECO:0000269|PubMed:15294897,ECO:0000269|PubMed:17004321}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MMP2_HNRNPA2B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MMP2_HNRNPA2B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MMP2_HNRNPA2B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMMP2P08253DB01197Captopril72 kDa type IV collagenasesmall moleculeapproved
TgeneHNRNPA2B1P22626DB11638ArtenimolHeterogeneous nuclear ribonucleoproteins A2/B1small moleculeapproved|investigational

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RelatedDiseases for MMP2_HNRNPA2B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMMP2C0027627Neoplasm Metastasis5CTD_human
HgeneMMP2C0027626Neoplasm Invasiveness4CTD_human
HgeneMMP2C0006663Calcinosis2CTD_human
HgeneMMP2C0009404Colorectal Neoplasms2CTD_human
HgeneMMP2C0023890Liver Cirrhosis2CTD_human
HgeneMMP2C0023893Liver Cirrhosis, Experimental2CTD_human
HgeneMMP2C0027051Myocardial Infarction2CTD_human
HgeneMMP2C0376634Craniofacial Abnormalities2CTD_human
HgeneMMP2C1458155Mammary Neoplasms2CTD_human
HgeneMMP2C1850155TORG-WINCHESTER SYNDROME2CTD_human;ORPHANET;UNIPROT
HgeneMMP2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneMMP2C0003493Aortic Diseases1CTD_human
HgeneMMP2C0003496Aortic Rupture1CTD_human
HgeneMMP2C0003873Rheumatoid Arthritis1CTD_human
HgeneMMP2C0005940Bone Diseases1CTD_human
HgeneMMP2C0005944Metabolic Bone Disorder1CTD_human
HgeneMMP2C0005967Bone neoplasms1CTD_human
HgeneMMP2C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneMMP2C0011882Diabetic Neuropathies1CTD_human
HgeneMMP2C0017636Glioblastoma1CTD_human
HgeneMMP2C0020538Hypertensive disease1CTD_human
HgeneMMP2C0021368Inflammation1CTD_human
HgeneMMP2C0023283Leishmaniasis, Cutaneous1CTD_human
HgeneMMP2C0023891Liver Cirrhosis, Alcoholic1CTD_human
HgeneMMP2C0024143Lupus Nephritis1CTD_human
HgeneMMP2C0024689Mandibular Diseases1CTD_human
HgeneMMP2C0024796Marfan Syndrome1CTD_human
HgeneMMP2C0024950Maxillary Diseases1CTD_human
HgeneMMP2C0027439Nasopharyngeal Neoplasms1CTD_human
HgeneMMP2C0028433Nose Neoplasms1CTD_human
HgeneMMP2C0029172Oral Submucous Fibrosis1CTD_human
HgeneMMP2C0029445Bone necrosis1CTD_human
HgeneMMP2C0029463Osteosarcoma1CTD_human
HgeneMMP2C0034067Pulmonary Emphysema1CTD_human
HgeneMMP2C0034069Pulmonary Fibrosis1CTD_human
HgeneMMP2C0043094Weight Gain1CTD_human
HgeneMMP2C0085762Alcohol abuse1PSYGENET
HgeneMMP2C0162872Aortic Aneurysm, Thoracic1CTD_human
HgeneMMP2C1336708Testicular Germ Cell Tumor1CTD_human
HgeneMMP2C2239176Liver carcinoma1CTD_human
HgeneMMP2C2931822Nasopharyngeal carcinoma1CTD_human
HgeneMMP2C2936380Neointima1CTD_human
HgeneMMP2C2937358Cerebral Hemorrhage1CTD_human
HgeneMMP2C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneHNRNPA2B1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneHNRNPA2B1C3809468INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 21UNIPROT