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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22222

FusionGeneSummary for MMP1_DCUN1D5

check button Fusion gene summary
Fusion gene informationFusion gene name: MMP1_DCUN1D5
Fusion gene ID: 22222
HgeneTgene
Gene symbol

MMP1

DCUN1D5

Gene ID

4312

84259

Gene namematrix metallopeptidase 1defective in cullin neddylation 1 domain containing 5
SynonymsCLG|CLGNSCCRO5
Cytomap

11q22.2

11q22.3

Type of geneprotein-codingprotein-coding
Descriptioninterstitial collagenasefibroblast collagenasematrix metallopeptidase 1 (interstitial collagenase)matrix metalloprotease 1matrix metalloproteinase 1DCN1-like protein 5DCN1, defective in cullin neddylation 1, domain containing 5DCUN1 domain-containing protein 5defective in cullin neddylation protein 1-like protein 5
Modification date2018052220180523
UniProtAcc

P03956

Q9BTE7

Ensembl transtripts involved in fusion geneENST00000315274, ENST00000260247, 
ENST00000531543, ENST00000529076, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MMP1 [Title/Abstract] AND DCUN1D5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMMP1

GO:0006508

proteolysis

15863497|19022250

HgeneMMP1

GO:0032461

positive regulation of protein oligomerization

19022250


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-MY-A913-01AMMP1chr11

102668797

-DCUN1D5chr11

102960035

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000315274ENST00000260247MMP1chr11

102668797

-DCUN1D5chr11

102960035

-
intron-intronENST00000315274ENST00000531543MMP1chr11

102668797

-DCUN1D5chr11

102960035

-
intron-5UTRENST00000315274ENST00000529076MMP1chr11

102668797

-DCUN1D5chr11

102960035

-

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FusionProtFeatures for MMP1_DCUN1D5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MMP1

P03956

DCUN1D5

Q9BTE7

Cleaves collagens of types I, II, and III at one site inthe helical domain. Also cleaves collagens of types VII and X(PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIVinfection, interacts and cleaves the secreted viral Tat protein,leading to a decrease in neuronal Tat's mediated neurotoxicity(PubMed:16807369). {ECO:0000269|PubMed:1645757,ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297,ECO:0000269|PubMed:2557822}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MMP1_DCUN1D5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MMP1_DCUN1D5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MMP1ITGA2, TIMP1, BCAN, BSG, SOX8, F2RDCUN1D5CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, UBE2M, RCHY1, HECW2, CAND1, RBX1, LNX1, UBE2F, PNKD, GNAI3, LYPD3, MAPK14, FAM177A1, SAC3D1, TLN2, UBL7, TEAD2, FOXL1, FOXL2, RNF7, DDB1, ACADVL, TMEM206, CD70, TMEM213, ORMDL1, RNF111, PTPN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MMP1_DCUN1D5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MMP1_DCUN1D5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMMP1C0027627Neoplasm Metastasis4CTD_human
HgeneMMP1C0002940Aneurysm1CTD_human
HgeneMMP1C0004153Atherosclerosis1CTD_human
HgeneMMP1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneMMP1C0009404Colorectal Neoplasms1CTD_human
HgeneMMP1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMMP1C0024121Lung Neoplasms1CTD_human
HgeneMMP1C0027626Neoplasm Invasiveness1CTD_human
HgeneMMP1C0028840Ocular Hypertension1CTD_human
HgeneMMP1C0029172Oral Submucous Fibrosis1CTD_human
HgeneMMP1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneMMP1C1458155Mammary Neoplasms1CTD_human