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Fusion gene ID: 22222 |
FusionGeneSummary for MMP1_DCUN1D5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MMP1_DCUN1D5 | Fusion gene ID: 22222 | Hgene | Tgene | Gene symbol | MMP1 | DCUN1D5 | Gene ID | 4312 | 84259 |
Gene name | matrix metallopeptidase 1 | defective in cullin neddylation 1 domain containing 5 | |
Synonyms | CLG|CLGN | SCCRO5 | |
Cytomap | 11q22.2 | 11q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | interstitial collagenasefibroblast collagenasematrix metallopeptidase 1 (interstitial collagenase)matrix metalloprotease 1matrix metalloproteinase 1 | DCN1-like protein 5DCN1, defective in cullin neddylation 1, domain containing 5DCUN1 domain-containing protein 5defective in cullin neddylation protein 1-like protein 5 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P03956 | Q9BTE7 | |
Ensembl transtripts involved in fusion gene | ENST00000315274, | ENST00000260247, ENST00000531543, ENST00000529076, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: MMP1 [Title/Abstract] AND DCUN1D5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MMP1 | GO:0006508 | proteolysis | 15863497|19022250 |
Hgene | MMP1 | GO:0032461 | positive regulation of protein oligomerization | 19022250 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-MY-A913-01A | MMP1 | chr11 | 102668797 | - | DCUN1D5 | chr11 | 102960035 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000315274 | ENST00000260247 | MMP1 | chr11 | 102668797 | - | DCUN1D5 | chr11 | 102960035 | - |
intron-intron | ENST00000315274 | ENST00000531543 | MMP1 | chr11 | 102668797 | - | DCUN1D5 | chr11 | 102960035 | - |
intron-5UTR | ENST00000315274 | ENST00000529076 | MMP1 | chr11 | 102668797 | - | DCUN1D5 | chr11 | 102960035 | - |
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FusionProtFeatures for MMP1_DCUN1D5 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MMP1 | DCUN1D5 |
Cleaves collagens of types I, II, and III at one site inthe helical domain. Also cleaves collagens of types VII and X(PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIVinfection, interacts and cleaves the secreted viral Tat protein,leading to a decrease in neuronal Tat's mediated neurotoxicity(PubMed:16807369). {ECO:0000269|PubMed:1645757,ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297,ECO:0000269|PubMed:2557822}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MMP1_DCUN1D5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MMP1_DCUN1D5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MMP1 | ITGA2, TIMP1, BCAN, BSG, SOX8, F2R | DCUN1D5 | CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, UBE2M, RCHY1, HECW2, CAND1, RBX1, LNX1, UBE2F, PNKD, GNAI3, LYPD3, MAPK14, FAM177A1, SAC3D1, TLN2, UBL7, TEAD2, FOXL1, FOXL2, RNF7, DDB1, ACADVL, TMEM206, CD70, TMEM213, ORMDL1, RNF111, PTPN1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MMP1_DCUN1D5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MMP1_DCUN1D5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MMP1 | C0027627 | Neoplasm Metastasis | 4 | CTD_human |
Hgene | MMP1 | C0002940 | Aneurysm | 1 | CTD_human |
Hgene | MMP1 | C0004153 | Atherosclerosis | 1 | CTD_human |
Hgene | MMP1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | MMP1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | MMP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | MMP1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | MMP1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | MMP1 | C0028840 | Ocular Hypertension | 1 | CTD_human |
Hgene | MMP1 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
Hgene | MMP1 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
Hgene | MMP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |