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Fusion gene ID: 22219 |
FusionGeneSummary for MMP15_CCDC135 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MMP15_CCDC135 | Fusion gene ID: 22219 | Hgene | Tgene | Gene symbol | MMP15 | CCDC135 | Gene ID | 4324 | 84229 |
| Gene name | matrix metallopeptidase 15 | dynein regulatory complex subunit 7 | |
| Synonyms | MMP-15|MT2-MMP|MT2MMP|MTMMP2|SMCP-2 | C16orf50|CCDC135|CFAP50|FAP50 | |
| Cytomap | 16q21 | 16q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | matrix metalloproteinase-15MT-MMP 2matrix metallopeptidase 15 (membrane-inserted)matrix metalloproteinase 15 (membrane-inserted)membrane-type matrix metalloproteinase 2membrane-type-2 matrix metalloproteinase | dynein regulatory complex subunit 7coiled-coil domain containing 135coiled-coil domain-containing protein 135coiled-coil domain-containing protein lobo homolog | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P51511 | ||
| Ensembl transtripts involved in fusion gene | ENST00000219271, | ENST00000360716, ENST00000394337, ENST00000336825, | |
| Fusion gene scores | * DoF score | 2 X 2 X 3=12 | 1 X 2 X 2=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MMP15 [Title/Abstract] AND CCDC135 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XJ-A9DX-01A | MMP15 | chr16 | 58077531 | + | CCDC135 | chr16 | 57759980 | + |
| TCGA | RV | STAD | TCGA-BR-8080-01A | MMP15 | chr16 | 58060416 | + | CCDC135 | chr16 | 57761211 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000219271 | ENST00000360716 | MMP15 | chr16 | 58077531 | + | CCDC135 | chr16 | 57759980 | + |
| Frame-shift | ENST00000219271 | ENST00000394337 | MMP15 | chr16 | 58077531 | + | CCDC135 | chr16 | 57759980 | + |
| Frame-shift | ENST00000219271 | ENST00000336825 | MMP15 | chr16 | 58077531 | + | CCDC135 | chr16 | 57759980 | + |
| In-frame | ENST00000219271 | ENST00000360716 | MMP15 | chr16 | 58060416 | + | CCDC135 | chr16 | 57761211 | + |
| In-frame | ENST00000219271 | ENST00000394337 | MMP15 | chr16 | 58060416 | + | CCDC135 | chr16 | 57761211 | + |
| In-frame | ENST00000219271 | ENST00000336825 | MMP15 | chr16 | 58060416 | + | CCDC135 | chr16 | 57761211 | + |
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FusionProtFeatures for MMP15_CCDC135 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MMP15 | CCDC135 |
| Endopeptidase that degrades various components of theextracellular matrix. May activate progelatinase A.{ECO:0000269|PubMed:9461298}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000336825 | + | 12 | 17 | 688_711 | 630 | 810 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000336825 | + | 12 | 17 | 781_807 | 630 | 810 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000360716 | + | 14 | 19 | 781_807 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000394337 | + | 13 | 18 | 781_807 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 331_340 | 54 | 670 | Compositional bias | Note=Poly-Pro |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 109_116 | 54 | 670 | Motif | Cysteine switch |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 367_415 | 54 | 670 | Repeat | Note=Hemopexin 1 |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 416_461 | 54 | 670 | Repeat | Note=Hemopexin 2 |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 463_511 | 54 | 670 | Repeat | Note=Hemopexin 3 |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 512_559 | 54 | 670 | Repeat | Note=Hemopexin 4 |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 132_625 | 54 | 670 | Topological domain | Extracellular |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 647_669 | 54 | 670 | Topological domain | Cytoplasmic |
| Hgene | >MMP15 | chr16:58060416 | chr16:57761211 | ENST00000219271 | + | 1 | 10 | 626_646 | 54 | 670 | Transmembrane | Helical |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000336825 | + | 12 | 17 | 1_67 | 630 | 810 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000336825 | + | 12 | 17 | 257_297 | 630 | 810 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000360716 | + | 14 | 19 | 1_67 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000360716 | + | 14 | 19 | 257_297 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000360716 | + | 14 | 19 | 688_711 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000394337 | + | 13 | 18 | 1_67 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000394337 | + | 13 | 18 | 257_297 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CCDC135 | chr16:58060416 | chr16:57761211 | ENST00000394337 | + | 13 | 18 | 688_711 | 695 | 875 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for MMP15_CCDC135 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000360716_chr16_57761211_+_234aa MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAEVLEILKLREEEEAAHTLTISIYDTKRNEKSKEYREA MERMMHEEHLRQVETQLDYLAPFLAQLPPGEKLTCWQAVRLKDECLSDFKQRLINKANLIQARFEKETQELQKKQQWYQENQVTLTPEDE >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000394337_chr16_57761211_+_234aa MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAEVLEILKLREEEEAAHTLTISIYDTKRNEKSKEYREA MERMMHEEHLRQVETQLDYLAPFLAQLPPGEKLTCWQAVRLKDECLSDFKQRLINKANLIQARFEKETQELQKKQQWYQENQVTLTPEDE >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000336825_chr16_57761211_+_234aa MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAEVLEILKLREEEEAAHTLTISIYDTKRNEKSKEYREA MERMMHEEHLRQVETQLDYLAPFLAQLPPGEKLTCWQAVRLKDECLSDFKQRLINKANLIQARFEKETQELQKKQQWYQENQVTLTPEDE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000360716_chr16_57761211_+_702nt ATGGGCAGCGACCCGAGCGCGCCCGGACGGCCGGGCTGGACGGGCAGCCTCCTCGGCGACCGGGAGGAGGCGGCGCGGCCGCGACTGCTG CCGCTGCTCCTGGTGCTTCTGGGCTGCCTGGGCCTTGGCGTAGCGGCCGAAGACGCGGAGGTCCATGCCGAGGTGCTGGAGATTCTGAAG CTTCGAGAGGAAGAGGAGGCGGCGCACACACTGACCATCTCCATCTATGACACCAAGCGGAATGAGAAGAGCAAGGAATATCGGGAGGCC ATGGAGCGCATGATGCACGAAGAGCACCTGCGGCAGGTGGAGACCCAGCTGGACTACCTGGCCCCATTCCTGGCCCAGCTCCCGCCAGGA GAGAAACTAACATGCTGGCAGGCGGTGCGCCTCAAGGATGAGTGCCTCAGCGACTTCAAGCAGCGGCTCATCAACAAGGCCAACCTCATC CAGGCCCGCTTTGAGAAGGAGACCCAGGAGCTGCAAAAGAAGCAGCAGTGGTACCAGGAGAACCAGGTGACGCTGACACCCGAGGATGAA GACCTGTACCTGAGTTACTGCTCTCAGGCCATGTTCCGCATCCGCATCCTGGAGCAGCGCCTCAATCGACACAAGGAACTGGCCCCACTG >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000394337_chr16_57761211_+_702nt ATGGGCAGCGACCCGAGCGCGCCCGGACGGCCGGGCTGGACGGGCAGCCTCCTCGGCGACCGGGAGGAGGCGGCGCGGCCGCGACTGCTG CCGCTGCTCCTGGTGCTTCTGGGCTGCCTGGGCCTTGGCGTAGCGGCCGAAGACGCGGAGGTCCATGCCGAGGTGCTGGAGATTCTGAAG CTTCGAGAGGAAGAGGAGGCGGCGCACACACTGACCATCTCCATCTATGACACCAAGCGGAATGAGAAGAGCAAGGAATATCGGGAGGCC ATGGAGCGCATGATGCACGAAGAGCACCTGCGGCAGGTGGAGACCCAGCTGGACTACCTGGCCCCATTCCTGGCCCAGCTCCCGCCAGGA GAGAAACTAACATGCTGGCAGGCGGTGCGCCTCAAGGATGAGTGCCTCAGCGACTTCAAGCAGCGGCTCATCAACAAGGCCAACCTCATC CAGGCCCGCTTTGAGAAGGAGACCCAGGAGCTGCAAAAGAAGCAGCAGTGGTACCAGGAGAACCAGGTGACGCTGACACCCGAGGATGAA GACCTGTACCTGAGTTACTGCTCTCAGGCCATGTTCCGCATCCGCATCCTGGAGCAGCGCCTCAATCGACACAAGGAACTGGCCCCACTG >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000336825_chr16_57761211_+_702nt ATGGGCAGCGACCCGAGCGCGCCCGGACGGCCGGGCTGGACGGGCAGCCTCCTCGGCGACCGGGAGGAGGCGGCGCGGCCGCGACTGCTG CCGCTGCTCCTGGTGCTTCTGGGCTGCCTGGGCCTTGGCGTAGCGGCCGAAGACGCGGAGGTCCATGCCGAGGTGCTGGAGATTCTGAAG CTTCGAGAGGAAGAGGAGGCGGCGCACACACTGACCATCTCCATCTATGACACCAAGCGGAATGAGAAGAGCAAGGAATATCGGGAGGCC ATGGAGCGCATGATGCACGAAGAGCACCTGCGGCAGGTGGAGACCCAGCTGGACTACCTGGCCCCATTCCTGGCCCAGCTCCCGCCAGGA GAGAAACTAACATGCTGGCAGGCGGTGCGCCTCAAGGATGAGTGCCTCAGCGACTTCAAGCAGCGGCTCATCAACAAGGCCAACCTCATC CAGGCCCGCTTTGAGAAGGAGACCCAGGAGCTGCAAAAGAAGCAGCAGTGGTACCAGGAGAACCAGGTGACGCTGACACCCGAGGATGAA GACCTGTACCTGAGTTACTGCTCTCAGGCCATGTTCCGCATCCGCATCCTGGAGCAGCGCCTCAATCGACACAAGGAACTGGCCCCACTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000360716_chr16_57761211_+_1682nt CGCGGGGTGGGCTGGAGAGGTTTCCTGCCGTCTGGGAAGCGTAAACGGACCGCCCACCTGTCGGGCCTCGGCCGCCCGCACCTGCTTGTG AGAAGCCTGCGGCTGGGGCACCGCCCCCGGTCCCCGCCCGGGTCCGCGCATTGGGAGCACACTGGCCCTTTAAGAGCGCGGCGGCCGCGG CGCGCGGGGAGGAGGGCTGGGAGCGCCCGGAGCCGCGCTGAACTCGCCGGGGACGTCGGGCGCCCGCTCCTTGGCTGGCTCGCTTGCTCT CTCGCTCGCTCTCTCGGGTCGGCTCCCTGCGCCTCCTCCCGGGACTGCTTGGGGACCCGGGCCCGGTCGGGCGCGGCGGCGAGCAGAATC CCCGTGCAGGAGGCGCGCGCTCCGGGCAGCGCCCGGCCCCGGGCATGGACAGAGGGAGCTGGGCGCGCAGGGAGCGCCGCGGGACCGGGC GGCCGGAGCGCTGAGCCAGACAAAGGCTCCGGAGTTGCGCTTGCTCTCGGGAGCCGGGCCCCAGGCGCTGGGCGCCGAGGCTGCGGAACC TCGCCGGGGGCAGCTCCGGTCGGCCCCCTTTCCCGCCGGCTGGTTCCGAGCTCCCGGACCTGCCCTGCCCGCTTCTCCTCGGGCTTGGGA ATTTGCCGAGGCGACCTAGGCGGCTCCGGCGGGGACCGGGAGCCCGAGGTCCGCGGCGCGCCTGCCGGGCCAGGAGCCAGGGAGCGTCGC AAGTTTCCAAGGCGCGTGCGAGGATCCGGCGTGCAGTGTTCCGAGCTGGGCTGGGCGCCGAGAGCATGGGCAGCGACCCGAGCGCGCCCG GACGGCCGGGCTGGACGGGCAGCCTCCTCGGCGACCGGGAGGAGGCGGCGCGGCCGCGACTGCTGCCGCTGCTCCTGGTGCTTCTGGGCT GCCTGGGCCTTGGCGTAGCGGCCGAAGACGCGGAGGTCCATGCCGAGGTGCTGGAGATTCTGAAGCTTCGAGAGGAAGAGGAGGCGGCGC ACACACTGACCATCTCCATCTATGACACCAAGCGGAATGAGAAGAGCAAGGAATATCGGGAGGCCATGGAGCGCATGATGCACGAAGAGC ACCTGCGGCAGGTGGAGACCCAGCTGGACTACCTGGCCCCATTCCTGGCCCAGCTCCCGCCAGGAGAGAAACTAACATGCTGGCAGGCGG TGCGCCTCAAGGATGAGTGCCTCAGCGACTTCAAGCAGCGGCTCATCAACAAGGCCAACCTCATCCAGGCCCGCTTTGAGAAGGAGACCC AGGAGCTGCAAAAGAAGCAGCAGTGGTACCAGGAGAACCAGGTGACGCTGACACCCGAGGATGAAGACCTGTACCTGAGTTACTGCTCTC AGGCCATGTTCCGCATCCGCATCCTGGAGCAGCGCCTCAATCGACACAAGGAACTGGCCCCACTGAAGTACCTGGCTCTGGAGGAAAAGC TCTACAAGGACCCACGCCTGGGGGAGCTCCAGAAAATATTCGCTTGATGTCCCTCCTGGGGCCTCAGCCAGAGCTGCCAGAGAAAGGAAA CCTCTTCCCGCAGCCTGGCTCCTGTGTTCCCTCTATCCAGCCAATGCCTGTTTACACAGACACCTGGCCTCACTGCCAGCCCACCTCCCC >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000394337_chr16_57761211_+_1684nt CGCGGGGTGGGCTGGAGAGGTTTCCTGCCGTCTGGGAAGCGTAAACGGACCGCCCACCTGTCGGGCCTCGGCCGCCCGCACCTGCTTGTG AGAAGCCTGCGGCTGGGGCACCGCCCCCGGTCCCCGCCCGGGTCCGCGCATTGGGAGCACACTGGCCCTTTAAGAGCGCGGCGGCCGCGG CGCGCGGGGAGGAGGGCTGGGAGCGCCCGGAGCCGCGCTGAACTCGCCGGGGACGTCGGGCGCCCGCTCCTTGGCTGGCTCGCTTGCTCT CTCGCTCGCTCTCTCGGGTCGGCTCCCTGCGCCTCCTCCCGGGACTGCTTGGGGACCCGGGCCCGGTCGGGCGCGGCGGCGAGCAGAATC CCCGTGCAGGAGGCGCGCGCTCCGGGCAGCGCCCGGCCCCGGGCATGGACAGAGGGAGCTGGGCGCGCAGGGAGCGCCGCGGGACCGGGC GGCCGGAGCGCTGAGCCAGACAAAGGCTCCGGAGTTGCGCTTGCTCTCGGGAGCCGGGCCCCAGGCGCTGGGCGCCGAGGCTGCGGAACC TCGCCGGGGGCAGCTCCGGTCGGCCCCCTTTCCCGCCGGCTGGTTCCGAGCTCCCGGACCTGCCCTGCCCGCTTCTCCTCGGGCTTGGGA ATTTGCCGAGGCGACCTAGGCGGCTCCGGCGGGGACCGGGAGCCCGAGGTCCGCGGCGCGCCTGCCGGGCCAGGAGCCAGGGAGCGTCGC AAGTTTCCAAGGCGCGTGCGAGGATCCGGCGTGCAGTGTTCCGAGCTGGGCTGGGCGCCGAGAGCATGGGCAGCGACCCGAGCGCGCCCG GACGGCCGGGCTGGACGGGCAGCCTCCTCGGCGACCGGGAGGAGGCGGCGCGGCCGCGACTGCTGCCGCTGCTCCTGGTGCTTCTGGGCT GCCTGGGCCTTGGCGTAGCGGCCGAAGACGCGGAGGTCCATGCCGAGGTGCTGGAGATTCTGAAGCTTCGAGAGGAAGAGGAGGCGGCGC ACACACTGACCATCTCCATCTATGACACCAAGCGGAATGAGAAGAGCAAGGAATATCGGGAGGCCATGGAGCGCATGATGCACGAAGAGC ACCTGCGGCAGGTGGAGACCCAGCTGGACTACCTGGCCCCATTCCTGGCCCAGCTCCCGCCAGGAGAGAAACTAACATGCTGGCAGGCGG TGCGCCTCAAGGATGAGTGCCTCAGCGACTTCAAGCAGCGGCTCATCAACAAGGCCAACCTCATCCAGGCCCGCTTTGAGAAGGAGACCC AGGAGCTGCAAAAGAAGCAGCAGTGGTACCAGGAGAACCAGGTGACGCTGACACCCGAGGATGAAGACCTGTACCTGAGTTACTGCTCTC AGGCCATGTTCCGCATCCGCATCCTGGAGCAGCGCCTCAATCGACACAAGGAACTGGCCCCACTGAAGTACCTGGCTCTGGAGGAAAAGC TCTACAAGGACCCACGCCTGGGGGAGCTCCAGAAAATATTCGCTTGATGTCCCTCCTGGGGCCTCAGCCAGAGCTGCCAGAGAAAGGAAA CCTCTTCCCGCAGCCTGGCTCCTGTGTTCCCTCTATCCAGCCAATGCCTGTTTACACAGACACCTGGCCTCACTGCCAGCCCACCTCCCC >In-frame_MMP15_ENST00000219271_chr16_58060416_+_CCDC135_ENST00000336825_chr16_57761211_+_1683nt CGCGGGGTGGGCTGGAGAGGTTTCCTGCCGTCTGGGAAGCGTAAACGGACCGCCCACCTGTCGGGCCTCGGCCGCCCGCACCTGCTTGTG AGAAGCCTGCGGCTGGGGCACCGCCCCCGGTCCCCGCCCGGGTCCGCGCATTGGGAGCACACTGGCCCTTTAAGAGCGCGGCGGCCGCGG CGCGCGGGGAGGAGGGCTGGGAGCGCCCGGAGCCGCGCTGAACTCGCCGGGGACGTCGGGCGCCCGCTCCTTGGCTGGCTCGCTTGCTCT CTCGCTCGCTCTCTCGGGTCGGCTCCCTGCGCCTCCTCCCGGGACTGCTTGGGGACCCGGGCCCGGTCGGGCGCGGCGGCGAGCAGAATC CCCGTGCAGGAGGCGCGCGCTCCGGGCAGCGCCCGGCCCCGGGCATGGACAGAGGGAGCTGGGCGCGCAGGGAGCGCCGCGGGACCGGGC GGCCGGAGCGCTGAGCCAGACAAAGGCTCCGGAGTTGCGCTTGCTCTCGGGAGCCGGGCCCCAGGCGCTGGGCGCCGAGGCTGCGGAACC TCGCCGGGGGCAGCTCCGGTCGGCCCCCTTTCCCGCCGGCTGGTTCCGAGCTCCCGGACCTGCCCTGCCCGCTTCTCCTCGGGCTTGGGA ATTTGCCGAGGCGACCTAGGCGGCTCCGGCGGGGACCGGGAGCCCGAGGTCCGCGGCGCGCCTGCCGGGCCAGGAGCCAGGGAGCGTCGC AAGTTTCCAAGGCGCGTGCGAGGATCCGGCGTGCAGTGTTCCGAGCTGGGCTGGGCGCCGAGAGCATGGGCAGCGACCCGAGCGCGCCCG GACGGCCGGGCTGGACGGGCAGCCTCCTCGGCGACCGGGAGGAGGCGGCGCGGCCGCGACTGCTGCCGCTGCTCCTGGTGCTTCTGGGCT GCCTGGGCCTTGGCGTAGCGGCCGAAGACGCGGAGGTCCATGCCGAGGTGCTGGAGATTCTGAAGCTTCGAGAGGAAGAGGAGGCGGCGC ACACACTGACCATCTCCATCTATGACACCAAGCGGAATGAGAAGAGCAAGGAATATCGGGAGGCCATGGAGCGCATGATGCACGAAGAGC ACCTGCGGCAGGTGGAGACCCAGCTGGACTACCTGGCCCCATTCCTGGCCCAGCTCCCGCCAGGAGAGAAACTAACATGCTGGCAGGCGG TGCGCCTCAAGGATGAGTGCCTCAGCGACTTCAAGCAGCGGCTCATCAACAAGGCCAACCTCATCCAGGCCCGCTTTGAGAAGGAGACCC AGGAGCTGCAAAAGAAGCAGCAGTGGTACCAGGAGAACCAGGTGACGCTGACACCCGAGGATGAAGACCTGTACCTGAGTTACTGCTCTC AGGCCATGTTCCGCATCCGCATCCTGGAGCAGCGCCTCAATCGACACAAGGAACTGGCCCCACTGAAGTACCTGGCTCTGGAGGAAAAGC TCTACAAGGACCCACGCCTGGGGGAGCTCCAGAAAATATTCGCTTGATGTCCCTCCTGGGGCCTCAGCCAGAGCTGCCAGAGAAAGGAAA CCTCTTCCCGCAGCCTGGCTCCTGTGTTCCCTCTATCCAGCCAATGCCTGTTTACACAGACACCTGGCCTCACTGCCAGCCCACCTCCCC |
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FusionGenePPI for MMP15_CCDC135 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MMP15 | TMEM67 | CCDC135 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MMP15_CCDC135 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MMP15_CCDC135 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MMP15 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Hgene | MMP15 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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