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Fusion gene ID: 22214 |
FusionGeneSummary for MMP14_CCT5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MMP14_CCT5 | Fusion gene ID: 22214 | Hgene | Tgene | Gene symbol | MMP14 | CCT5 | Gene ID | 4323 | 22948 |
| Gene name | matrix metallopeptidase 14 | chaperonin containing TCP1 subunit 5 | |
| Synonyms | MMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRS | CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon | |
| Cytomap | 14q11.2 | 5p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | matrix metalloproteinase-14matrix metallopeptidase 14 (membrane-inserted)membrane type 1 metalloproteasemembrane-type-1 matrix metalloproteinase | T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P50281 | P48643 | |
| Ensembl transtripts involved in fusion gene | ENST00000311852, ENST00000548162, | ENST00000280326, ENST00000503026, ENST00000515390, ENST00000515676, ENST00000506600, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 49 X 6 X 16=4704 |
| # samples | 5 | 53 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(53/4704*10)=-3.1498237953858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MMP14 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MMP14 | GO:0006508 | proteolysis | 15863497|24970228 |
| Hgene | MMP14 | GO:0030307 | positive regulation of cell growth | 22065321 |
| Hgene | MMP14 | GO:0030335 | positive regulation of cell migration | 22065321 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-IW-A3M6-01A | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000311852 | ENST00000280326 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000311852 | ENST00000503026 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000311852 | ENST00000515390 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000311852 | ENST00000515676 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000311852 | ENST00000506600 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000548162 | ENST00000280326 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000548162 | ENST00000503026 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000548162 | ENST00000515390 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000548162 | ENST00000515676 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000548162 | ENST00000506600 | MMP14 | chr14 | 23316970 | + | CCT5 | chr5 | 10250033 | + |
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FusionProtFeatures for MMP14_CCT5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MMP14 | CCT5 |
| Endopeptidase that degrades various components of theextracellular matrix such as collagen. Activates progelatinase A.Essential for pericellular collagenolysis and modeling of skeletaland extraskeletal connective tissues during development (Bysimilarity). May be involved in actin cytoskeleton reorganizationby cleaving PTK7 (PubMed:20837484). Acts as a positive regulatorof cell growth and migration via activation of MMP15. Involved inthe formation of the fibrovascular tissues in association withpro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to releasevasculostatin-40 which inhibits angiogenesis (PubMed:22330140).{ECO:0000250|UniProtKB:P53690, ECO:0000269|PubMed:12714657,ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321,ECO:0000269|PubMed:22330140}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 91_98 | 1157 | 583 | Motif | Cysteine switch |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 316_364 | 1157 | 583 | Repeat | Note=Hemopexin 1 |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 365_410 | 1157 | 583 | Repeat | Note=Hemopexin 2 |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 412_460 | 1157 | 583 | Repeat | Note=Hemopexin 3 |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 461_508 | 1157 | 583 | Repeat | Note=Hemopexin 4 |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 112_541 | 1157 | 583 | Topological domain | Extracellular |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 563_582 | 1157 | 583 | Topological domain | Cytoplasmic |
| Hgene | MMP14 | chr14:23316970 | chr5:10250033 | ENST00000311852 | + | 10 | 10 | 542_562 | 1157 | 583 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MMP14_CCT5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MMP14_ENST00000311852_chr14_23316970_+_CCT5_ENST00000280326_chr5_10250033_+_1839aa MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRR PRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFV LPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYP KNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKVXRPPPARPLLPQGLCLXRPVAAGGGGWAVPIVPSPLPAASLLLSVPWL ASFTLTASLPPAPALHLPXIGPLRAEWEGGPFQPLPLRGTLXLCVCPAPSECVGGSALEGRTLRPRWXRSNGVICSFSIPXHTLTSELXP QEALGTPALKAPGVPNWQPLTTLSGXKESNLVEGRDPETVXGGGDCQATLRPWEENSERVFVAQSVKFLGDLPLPHLPQGTSKEGAXATG DXVGRRNPWQPCASRMLALDGAFTVRRAETRGAAVRXGGAGGRGPGQSPGGEPEGHRERTLPKLRQLGLRPKGRTARGGRRGPKRKMRTC SSIGRLGPGRPGQAKQGATGWAVELSGRALRKAHLLLLVPVLAAQAAWRGRVGQPEKGAEKAHKRGMRGFTRGHRAWLATLSRPAHHLSE GQELGLAXAGSTLPWCQHPSSLSHQWPALSLPHPAHPLKSPWATKGGGHGTGDLGEXDPVEGARGEGCRGGGARGRGNGVNGAGSSARFL SCLFFCFVXCIFLLXLLYMNSIQIVPFCXQGAWGGVGVGGQRRLTPGTCRAGLGRCPLRTILTLFNLSTKNKLCFTFKKKKNRKWVLPSS RSRSAKKXRNSALSQXIPPWDPLSRNYQWXRFKKXQIQSALDLCVLRFPLSVFKPPPPRLPGXXKFPKAADSRRYCLAXNXSQXKHKSRA SCAARAQAFGPSREREVHSRFRSGLRRLGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLG PNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARV AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKD FSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVR WVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLI RDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MMP14_ENST00000311852_chr14_23316970_+_CCT5_ENST00000280326_chr5_10250033_+_5517nt ATGTCTCCCGCCCCAAGACCCCCCCGTTGTCTCCTGCTCCCCCTGCTCACGCTCGGCACCGCGCTCGCCTCCCTCGGCTCGGCCCAAAGC AGCAGCTTCAGCCCCGAAGCCTGGCTACAGCAATATGGCTACCTGCCTCCCGGGGACCTACGTACCCACACACAGCGCTCACCCCAGTCA CTCTCAGCGGCCATCGCTGCCATGCAGAAGTTTTACGGCTTGCAAGTAACAGGCAAAGCTGATGCAGACACCATGAAGGCCATGAGGCGC CCCCGATGTGGTGTTCCAGACAAGTTTGGGGCTGAGATCAAGGCCAATGTTCGAAGGAAGCGCTACGCCATCCAGGGTCTCAAATGGCAA CATAATGAAATCACTTTCTGCATCCAGAATTACACCCCCAAGGTGGGCGAGTATGCCACATACGAGGCCATTCGCAAGGCGTTCCGCGTG TGGGAGAGTGCCACACCACTGCGCTTCCGCGAGGTGCCCTATGCCTACATCCGTGAGGGCCATGAGAAGCAGGCCGACATCATGATCTTC TTTGCCGAGGGCTTCCATGGCGACAGCACGCCCTTCGATGGTGAGGGCGGCTTCCTGGCCCATGCCTACTTCCCAGGCCCCAACATTGGA GGAGACACCCACTTTGACTCTGCCGAGCCTTGGACTGTCAGGAATGAGGATCTGAATGGAAATGACATCTTCCTGGTGGCTGTGCACGAG CTGGGCCATGCCCTGGGGCTCGAGCATTCCAGTGACCCCTCGGCCATCATGGCACCCTTTTACCAGTGGATGGACACGGAGAATTTTGTG CTGCCCGATGATGACCGCCGGGGCATCCAGCAACTTTATGGGGGTGAGTCAGGGTTCCCCACCAAGATGCCCCCTCAACCCAGGACTACC TCCCGGCCTTCTGTTCCTGATAAACCCAAAAACCCCACCTATGGGCCCAACATCTGTGACGGGAACTTTGACACCGTGGCCATGCTCCGA GGGGAGATGTTTGTCTTCAAGGAGCGCTGGTTCTGGCGGGTGAGGAATAACCAAGTGATGGATGGATACCCAATGCCCATTGGCCAGTTC TGGCGGGGCCTGCCTGCGTCCATCAACACTGCCTACGAGAGGAAGGATGGCAAATTCGTCTTCTTCAAAGGAGACAAGCATTGGGTGTTT GATGAGGCGTCCCTGGAACCTGGCTACCCCAAGCACATTAAGGAGCTGGGCCGAGGGCTGCCTACCGACAAGATTGATGCTGCTCTCTTC TGGATGCCCAATGGAAAGACCTACTTCTTCCGTGGAAACAAGTACTACCGTTTCAACGAAGAGCTCAGGGCAGTGGATAGCGAGTACCCC AAGAACATCAAAGTCTGGGAAGGGATCCCTGAGTCTCCCAGAGGGTCATTCATGGGCAGCGATGAAGTCTTCACTTACTTCTACAAGGGG AACAAATACTGGAAATTCAACAACCAGAAGCTGAAGGTAGAACCGGGCTACCCCAAGTCAGCCCTGAGGGACTGGATGGGCTGCCCATCG GGAGGCCGGCCGGATGAGGGGACTGAGGAGGAGACGGAGGTGATCATCATTGAGGTGGACGAGGAGGGCGGCGGGGCGGTGAGCGCGGCT GCCGTGGTGCTGCCCGTGCTGCTGCTGCTCCTGGTGCTGGCGGTGGGCCTTGCAGTCTTCTTCTTCAGACGCCATGGGACCCCCAGGCGA CTGCTCTACTGCCAGCGTTCCCTGCTGGACAAGGTCTGACGCCCACCGCCGGCCCGCCCACTCCTACCACAAGGACTTTGCCTCTGAAGG CCAGTGGCAGCAGGTGGTGGTGGGTGGGCTGTTCCCATCGTCCCGAGCCCCCTCCCCGCAGCCTCCTTGCTTCTCTCTGTCCCCTGGCTG GCCTCCTTCACCCTGACCGCCTCCCTCCCTCCTGCCCCGGCATTGCATCTTCCCTAGATAGGTCCCCTGAGGGCTGAGTGGGAGGGCGGC CCTTTCCAGCCTCTGCCCCTCAGGGGAACCCTGTAGCTTTGTGTCTGTCCAGCCCCATCTGAATGTGTTGGGGGCTCTGCACTTGAAGGC AGGACCCTCAGACCTCGCTGGTAAAGGTCAAATGGGGTCATCTGCTCCTTTTCCATCCCCTGACATACCTTAACCTCTGAACTCTGACCT CAGGAGGCTCTGGGCACTCCAGCCCTGAAAGCCCCAGGTGTACCCAATTGGCAGCCTCTCACTACTCTTTCTGGCTAAAAGGAATCTAAT CTTGTTGAGGGTAGAGACCCTGAGACAGTGTGAGGGGGTGGGGACTGCCAAGCCACCCTAAGACCTTGGGAGGAAAACTCAGAGAGGGTC TTCGTTGCTCAGTCAGTCAAGTTCCTCGGAGATCTGCCTCTGCCTCACCTACCCCAGGGAACTTCCAAGGAAGGAGCCTGAGCCACTGGG GACTAAGTGGGCAGAAGAAACCCTTGGCAGCCCTGTGCCTCTCGAATGTTAGCCTTGGATGGGGCTTTCACAGTTAGAAGAGCTGAAACC AGGGGTGCAGCTGTCAGGTAGGGTGGGGCCGGTGGGAGAGGCCCGGGTCAGAGCCCTGGGGGTGAGCCTGAAGGCCACAGAGAAAGAACC TTGCCCAAACTCAGGCAGCTGGGGCTGAGGCCCAAAGGCAGAACAGCCAGAGGGGGCAGGAGGGGACCAAAAAGGAAAATGAGGACGTGC AGCAGCATTGGAAGGCTGGGGCCGGGCAGGCCAGGCCAAGCCAAGCAGGGGGCCACAGGGTGGGCTGTGGAGCTCTCAGGAAGGGCCCTG AGGAAGGCACACTTGCTCCTGTTGGTCCCTGTCCTTGCTGCCCAGGCAGCGTGGAGGGGAAGGGTAGGGCAGCCAGAGAAAGGAGCAGAG AAGGCACACAAACGAGGAATGAGGGGCTTCACGAGAGGCCACAGGGCCTGGCTGGCCACGCTGTCCCGGCCTGCTCACCATCTCAGTGAG GGGCAGGAGCTGGGGCTCGCTTAGGCTGGGTCCACGCTTCCCTGGTGCCAGCACCCCTCAAGCCTGTCTCACCAGTGGCCTGCCCTCTCG CTCCCCCACCCAGCCCACCCATTGAAGTCTCCTTGGGCCACCAAAGGTGGTGGCCATGGTACCGGGGACTTGGGAGAGTGAGACCCAGTG GAGGGAGCAAGAGGAGAGGGATGTCGGGGGGGTGGGGCACGGGGTAGGGGAAATGGGGTGAACGGTGCTGGCAGTTCGGCTAGATTTCTG TCTTGTTTGTTTTTTTGTTTTGTTTAATGTATATTTTTATTATAATTATTATATATGAATTCCATTCAAATCGTTCCTTTTTGTTAACAA GGGGCATGGGGAGGGGTGGGGGTGGGGGGGCAGAGGCGTCTGACCCCAGGAACCTGCAGGGCGGGGCTGGGTCGGTGCCCTCTAAGGACA ATTTTGACCTTGTTCAACCTTTCCACAAAGAATAAATTGTGTTTCACATTCAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCT CGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAA CGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTT CCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCG TCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGA AGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGAC CGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGA CCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTT GATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCT GGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTT GCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTG GGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGAC GTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGAT TTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAG CATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAA GAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGC TGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTG GGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTA ACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATC CGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTA GAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACT ATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAA CAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MMP14_ENST00000311852_chr14_23316970_+_CCT5_ENST00000280326_chr5_10250033_+_7407nt ACCAGAGGAGAGAGCGAGAGAGGGAACCAGACCCCAGTTCGCCGACTAAGCAGAAGAAAGATCAAAAACCGGAAAAGAGGAGAAGAGCAA ACAGGCACTTTGAGGAACAATCCCCTTTAACTCCAAGCCGACAGCGGTCTAGGAATTCAAGTTCAGTGCCTACCGAAGACAAAGGCGCCC CGAGGGAGTGGCGGTGCGACCCCAGGGCGTGGGCCCGGCCGCGGAGCCCACACTGCCCGGCTGACCCGGTGGTCTCGGACCATGTCTCCC GCCCCAAGACCCCCCCGTTGTCTCCTGCTCCCCCTGCTCACGCTCGGCACCGCGCTCGCCTCCCTCGGCTCGGCCCAAAGCAGCAGCTTC AGCCCCGAAGCCTGGCTACAGCAATATGGCTACCTGCCTCCCGGGGACCTACGTACCCACACACAGCGCTCACCCCAGTCACTCTCAGCG GCCATCGCTGCCATGCAGAAGTTTTACGGCTTGCAAGTAACAGGCAAAGCTGATGCAGACACCATGAAGGCCATGAGGCGCCCCCGATGT GGTGTTCCAGACAAGTTTGGGGCTGAGATCAAGGCCAATGTTCGAAGGAAGCGCTACGCCATCCAGGGTCTCAAATGGCAACATAATGAA ATCACTTTCTGCATCCAGAATTACACCCCCAAGGTGGGCGAGTATGCCACATACGAGGCCATTCGCAAGGCGTTCCGCGTGTGGGAGAGT GCCACACCACTGCGCTTCCGCGAGGTGCCCTATGCCTACATCCGTGAGGGCCATGAGAAGCAGGCCGACATCATGATCTTCTTTGCCGAG GGCTTCCATGGCGACAGCACGCCCTTCGATGGTGAGGGCGGCTTCCTGGCCCATGCCTACTTCCCAGGCCCCAACATTGGAGGAGACACC CACTTTGACTCTGCCGAGCCTTGGACTGTCAGGAATGAGGATCTGAATGGAAATGACATCTTCCTGGTGGCTGTGCACGAGCTGGGCCAT GCCCTGGGGCTCGAGCATTCCAGTGACCCCTCGGCCATCATGGCACCCTTTTACCAGTGGATGGACACGGAGAATTTTGTGCTGCCCGAT GATGACCGCCGGGGCATCCAGCAACTTTATGGGGGTGAGTCAGGGTTCCCCACCAAGATGCCCCCTCAACCCAGGACTACCTCCCGGCCT TCTGTTCCTGATAAACCCAAAAACCCCACCTATGGGCCCAACATCTGTGACGGGAACTTTGACACCGTGGCCATGCTCCGAGGGGAGATG TTTGTCTTCAAGGAGCGCTGGTTCTGGCGGGTGAGGAATAACCAAGTGATGGATGGATACCCAATGCCCATTGGCCAGTTCTGGCGGGGC CTGCCTGCGTCCATCAACACTGCCTACGAGAGGAAGGATGGCAAATTCGTCTTCTTCAAAGGAGACAAGCATTGGGTGTTTGATGAGGCG TCCCTGGAACCTGGCTACCCCAAGCACATTAAGGAGCTGGGCCGAGGGCTGCCTACCGACAAGATTGATGCTGCTCTCTTCTGGATGCCC AATGGAAAGACCTACTTCTTCCGTGGAAACAAGTACTACCGTTTCAACGAAGAGCTCAGGGCAGTGGATAGCGAGTACCCCAAGAACATC AAAGTCTGGGAAGGGATCCCTGAGTCTCCCAGAGGGTCATTCATGGGCAGCGATGAAGTCTTCACTTACTTCTACAAGGGGAACAAATAC TGGAAATTCAACAACCAGAAGCTGAAGGTAGAACCGGGCTACCCCAAGTCAGCCCTGAGGGACTGGATGGGCTGCCCATCGGGAGGCCGG CCGGATGAGGGGACTGAGGAGGAGACGGAGGTGATCATCATTGAGGTGGACGAGGAGGGCGGCGGGGCGGTGAGCGCGGCTGCCGTGGTG CTGCCCGTGCTGCTGCTGCTCCTGGTGCTGGCGGTGGGCCTTGCAGTCTTCTTCTTCAGACGCCATGGGACCCCCAGGCGACTGCTCTAC TGCCAGCGTTCCCTGCTGGACAAGGTCTGACGCCCACCGCCGGCCCGCCCACTCCTACCACAAGGACTTTGCCTCTGAAGGCCAGTGGCA GCAGGTGGTGGTGGGTGGGCTGTTCCCATCGTCCCGAGCCCCCTCCCCGCAGCCTCCTTGCTTCTCTCTGTCCCCTGGCTGGCCTCCTTC ACCCTGACCGCCTCCCTCCCTCCTGCCCCGGCATTGCATCTTCCCTAGATAGGTCCCCTGAGGGCTGAGTGGGAGGGCGGCCCTTTCCAG CCTCTGCCCCTCAGGGGAACCCTGTAGCTTTGTGTCTGTCCAGCCCCATCTGAATGTGTTGGGGGCTCTGCACTTGAAGGCAGGACCCTC AGACCTCGCTGGTAAAGGTCAAATGGGGTCATCTGCTCCTTTTCCATCCCCTGACATACCTTAACCTCTGAACTCTGACCTCAGGAGGCT CTGGGCACTCCAGCCCTGAAAGCCCCAGGTGTACCCAATTGGCAGCCTCTCACTACTCTTTCTGGCTAAAAGGAATCTAATCTTGTTGAG GGTAGAGACCCTGAGACAGTGTGAGGGGGTGGGGACTGCCAAGCCACCCTAAGACCTTGGGAGGAAAACTCAGAGAGGGTCTTCGTTGCT CAGTCAGTCAAGTTCCTCGGAGATCTGCCTCTGCCTCACCTACCCCAGGGAACTTCCAAGGAAGGAGCCTGAGCCACTGGGGACTAAGTG GGCAGAAGAAACCCTTGGCAGCCCTGTGCCTCTCGAATGTTAGCCTTGGATGGGGCTTTCACAGTTAGAAGAGCTGAAACCAGGGGTGCA GCTGTCAGGTAGGGTGGGGCCGGTGGGAGAGGCCCGGGTCAGAGCCCTGGGGGTGAGCCTGAAGGCCACAGAGAAAGAACCTTGCCCAAA CTCAGGCAGCTGGGGCTGAGGCCCAAAGGCAGAACAGCCAGAGGGGGCAGGAGGGGACCAAAAAGGAAAATGAGGACGTGCAGCAGCATT GGAAGGCTGGGGCCGGGCAGGCCAGGCCAAGCCAAGCAGGGGGCCACAGGGTGGGCTGTGGAGCTCTCAGGAAGGGCCCTGAGGAAGGCA CACTTGCTCCTGTTGGTCCCTGTCCTTGCTGCCCAGGCAGCGTGGAGGGGAAGGGTAGGGCAGCCAGAGAAAGGAGCAGAGAAGGCACAC AAACGAGGAATGAGGGGCTTCACGAGAGGCCACAGGGCCTGGCTGGCCACGCTGTCCCGGCCTGCTCACCATCTCAGTGAGGGGCAGGAG CTGGGGCTCGCTTAGGCTGGGTCCACGCTTCCCTGGTGCCAGCACCCCTCAAGCCTGTCTCACCAGTGGCCTGCCCTCTCGCTCCCCCAC CCAGCCCACCCATTGAAGTCTCCTTGGGCCACCAAAGGTGGTGGCCATGGTACCGGGGACTTGGGAGAGTGAGACCCAGTGGAGGGAGCA AGAGGAGAGGGATGTCGGGGGGGTGGGGCACGGGGTAGGGGAAATGGGGTGAACGGTGCTGGCAGTTCGGCTAGATTTCTGTCTTGTTTG TTTTTTTGTTTTGTTTAATGTATATTTTTATTATAATTATTATATATGAATTCCATTCAAATCGTTCCTTTTTGTTAACAAGGGGCATGG GGAGGGGTGGGGGTGGGGGGGCAGAGGCGTCTGACCCCAGGAACCTGCAGGGCGGGGCTGGGTCGGTGCCCTCTAAGGACAATTTTGACC TTGTTCAACCTTTCCACAAAGAATAAATTGTGTTTCACATTCAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGG AGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAA AAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAA TAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCT GCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCC GGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCC CGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGG CTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAG ATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTG TTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAA CACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAA GTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTT GAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCAC CCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTG GATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGT GCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGA GGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCT GGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTT ATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAAT CGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTAT GCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAA GTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTC ATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCT GGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTAC AGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCT GTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTT AAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACT ATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGC CATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTA GGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATG TGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTA AATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCT AACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCAC ATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGT GGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGC TCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAA GTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATT GGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTT GAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTT ATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGA TTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAATAAACCTCTTCCAC |
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FusionGenePPI for MMP14_CCT5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MMP14 | LUM, LRP1, TIMP2, C1QBP, SPOCK3, BCAR1, RRAD, PLLP, CCDC155, FURIN, MMP3, TIMP1 | CCT5 | XRN1, THEG, SSSCA1, HDAC3, ACTB, TBC1D17, IKBKAP, IMMT, TP53, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, TRAF3IP3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, GPN1, HNRNPH1, RPAP2, RPAP3, CDK9, RFWD2, SRRM2, SRRM1, WDR82, H2AFX, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO4, HDAC5, PCK1, VHL, SIRT7, FBXO25, CUL3, CUL4A, CDK2, GNB5, GNB1, RGS7, PDCL, GRB2, PACRG, CCT2, CCT3, CCT8, CCT6A, CCT4, CCT7, CCT6B, AHCYL1, IARS, TARS, PSMA6, PSMB1, VCP, SSR1, XPO1, SLU7, TXNL1, SRSF2, ATXN2, TRIM28, FN1, VCAM1, ATF2, PEX14, NOS2, FAM86B2, METTL21B, ITGA4, PAN2, HDAC6, FBXW4, TERT, FBXO6, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TUBG1, HUWE1, FUS, CUL7, OBSL1, RNF2, SIRT6, IKBKE, IRAK1, SGK2, TSSK6, TYK2, WDR76, POC1A, PEX7, RPS6KB2, DCAF7, UNK, ACTR2, AHNAK, HSPE1, PIN4, STUB1, NTRK1, BTRC, B9D1, MKS1, CETN2, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, WRAP53, RFWD3, KIF21A, SEH1L, KBTBD7, TUBA1C, ARMC6, GAN, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, CRBN, PPM1J, KLHDC8A, DNAI2, HCFC2, WDR77, DCAF11, KDM4B, KLHL33, KLHDC2, TXNDC9, WDR86, TBL1Y, DCAF8, THOC3, WDTC1, GANAB, ODF1, DCAF5, SEC31B, TSSC1, WDR83, CYLD, WDR92, TRIM25, MCPH1, HEY1, BRCA1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MMP14_CCT5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MMP14_CCT5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MMP14 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | MMP14 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | MMP14 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | MMP14 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
| Hgene | MMP14 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | MMP14 | C0162871 | Aortic Aneurysm, Abdominal | 1 | CTD_human |
| Hgene | MMP14 | C0432289 | Winchester syndrome (disorder) | 1 | UNIPROT |
| Hgene | MMP14 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CCT5 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | CCT5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CCT5 | C1850395 | Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive | 1 | CTD_human;ORPHANET;UNIPROT |
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