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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22197

FusionGeneSummary for MLX_MLX

check button Fusion gene summary
Fusion gene informationFusion gene name: MLX_MLX
Fusion gene ID: 22197
HgeneTgene
Gene symbol

MLX

MLX

Gene ID

51085

51085

Gene nameMLX interacting protein likeMLX interacting protein like
SynonymsCHREBP|MIO|MLX|MONDOB|WBSCR14|WS-bHLH|bHLHd14CHREBP|MIO|MLX|MONDOB|WBSCR14|WS-bHLH|bHLHd14
Cytomap

7q11.23

7q11.23

Type of geneprotein-codingprotein-coding
Descriptioncarbohydrate-responsive element-binding proteinMlx interactorWS basic-helix-loop-helix leucine zipper proteinWilliams Beuren syndrome chromosome region 14Williams-Beuren syndrome chromosome region 14 protein 1Williams-Beuren syndrome chromosome regiocarbohydrate-responsive element-binding proteinMlx interactorWS basic-helix-loop-helix leucine zipper proteinWilliams Beuren syndrome chromosome region 14Williams-Beuren syndrome chromosome region 14 protein 1Williams-Beuren syndrome chromosome regio
Modification date2018052320180523
UniProtAcc

Q9UH92

Q9UH92

Ensembl transtripts involved in fusion geneENST00000435881, ENST00000246912, 
ENST00000346833, 
ENST00000435881, 
ENST00000246912, ENST00000346833, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 1=9
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MLX [Title/Abstract] AND MLX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE085890MLXchr17

40722062

-MLXchr17

40723723

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000435881ENST00000435881MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000435881ENST00000246912MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000435881ENST00000346833MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000246912ENST00000435881MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000246912ENST00000246912MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000246912ENST00000346833MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000346833ENST00000435881MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000346833ENST00000246912MLXchr17

40722062

-MLXchr17

40723723

+
5CDS-3UTRENST00000346833ENST00000346833MLXchr17

40722062

-MLXchr17

40723723

+

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FusionProtFeatures for MLX_MLX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLX

Q9UH92

MLX

Q9UH92


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MLX_MLX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MLX_MLX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MLX_MLX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MLX_MLX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource