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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22178

FusionGeneSummary for MLLT4_SYK

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT4_SYK
Fusion gene ID: 22178
HgeneTgene
Gene symbol

MLLT4

SYK

Gene ID

4301

6850

Gene nameafadin, adherens junction formation factorspleen associated tyrosine kinase
SynonymsAF6|MLL-AF6|MLLT4|l-afadinp72-Syk
Cytomap

6q27

9q22.2

Type of geneprotein-codingprotein-coding
DescriptionafadinALL1-fused gene from chromosome 6 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4protein AF-6tyrosine-protein kinase SYKspleen tyrosine kinase
Modification date2018052320180523
UniProtAcc

P43405

Ensembl transtripts involved in fusion geneENST00000344191, ENST00000351017, 
ENST00000392108, ENST00000392112, 
ENST00000366806, ENST00000447894, 
ENST00000400822, ENST00000507679, 
ENST00000375751, ENST00000375754, 
ENST00000375747, ENST00000476708, 
ENST00000375746, 
Fusion gene scores* DoF score8 X 4 X 6=1925 X 4 X 4=80
# samples 85
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLLT4 [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYK

GO:0006468

protein phosphorylation

17681949

TgeneSYK

GO:0007159

leukocyte cell-cell adhesion

12885943

TgeneSYK

GO:0030593

neutrophil chemotaxis

12885943


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-V1-A9OY-01AMLLT4chr6

168227917

+SYKchr9

93606140

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344191ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000344191ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000344191ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-3UTRENST00000344191ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000344191ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000351017ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000351017ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000351017ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-3UTRENST00000351017ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000351017ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392108ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392108ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392108ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-3UTRENST00000392108ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392108ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392112ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392112ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392112ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-3UTRENST00000392112ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000392112ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000366806ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000366806ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000366806ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-3UTRENST00000366806ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000366806ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000447894ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000447894ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000447894ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-3UTRENST00000447894ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000447894ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000400822ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000400822ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000400822ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-3UTRENST00000400822ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
5CDS-5UTRENST00000400822ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+
intron-5UTRENST00000507679ENST00000375751MLLT4chr6

168227917

+SYKchr9

93606140

+
intron-5UTRENST00000507679ENST00000375754MLLT4chr6

168227917

+SYKchr9

93606140

+
intron-5UTRENST00000507679ENST00000375747MLLT4chr6

168227917

+SYKchr9

93606140

+
intron-3UTRENST00000507679ENST00000476708MLLT4chr6

168227917

+SYKchr9

93606140

+
intron-5UTRENST00000507679ENST00000375746MLLT4chr6

168227917

+SYKchr9

93606140

+

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FusionProtFeatures for MLLT4_SYK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT4

SYK

P43405

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Non-receptor tyrosine kinase which mediates signaltransduction downstream of a variety of transmembrane receptorsincluding classical immunoreceptors like the B-cell receptor(BCR). Regulates several biological processes including innate andadaptive immunity, cell adhesion, osteoclast maturation, plateletactivation and vascular development. Assembles into signalingcomplexes with activated receptors at the plasma membrane viainteraction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor canalso be indirect and mediated by adapter proteins containing ITAMor partial hemITAM domains. The phosphorylation of the ITAMdomains is generally mediated by SRC subfamily kinases uponengagement of the receptor. More rarely signal transduction viaSYK could be ITAM-independent. Direct downstream effectorsphosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 andBLNK. Initially identified as essential in B-cell receptor (BCR)signaling, it is necessary for the maturation of B-cells mostprobably at the pro-B to pre-B transition. Activated upon BCRengagement, it phosphorylates and activates BLNK an adapterlinking the activated BCR to downstream signaling adapters andeffectors. It also phosphorylates and activates PLCG1 and the PKCsignaling pathway. It also phosphorylates BTK and regulates itsactivity in B-cell antigen receptor (BCR)-coupled signaling. Inaddition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innateimmune response to fungal, bacterial and viral pathogens. It isfor instance activated by the membrane lectin CLEC7A. Uponstimulation by fungal proteins, CLEC7A together with SYK activatesimmune cells inducing the production of ROS. Also activates theinflammasome and NF-kappa-B-mediated transcription of chemokinesand cytokines in presence of pathogens. Regulates neutrophildegranulation and phagocytosis through activation of the MAPKsignaling cascade. Also mediates the activation of dendritic cellsby cell necrosis stimuli. Also involved in mast cells activation.Involved in interleukin-3/IL3-mediated signaling pathway inbasophils (By similarity). Also functions downstream of receptorsmediating cell adhesion. Relays for instance, integrin-mediatedneutrophils and macrophages activation and P-selectinreceptor/SELPG-mediated recruitment of leukocytes to inflammatoryloci. Plays also a role in non-immune processes. It is forinstance involved in vascular development where it may regulateblood and lymphatic vascular separation. It is also required forosteoclast development and function. Functions in the activationof platelets by collagen, mediating PLCG2 phosphorylation andactivation. May be coupled to the collagen receptor by the ITAMdomain-containing FCER1G. Also activated by the membrane lectinCLEC1B that is required for activation of platelets byPDPN/podoplanin. Involved in platelet adhesion being activated byITGB3 engaged by fibrinogen. Together with CEACAM20, enhancesproduction of the cytokine CXCL8/IL-8 via the NFKB pathway and maythus have a role in the intestinal immune response (Bysimilarity). {ECO:0000250|UniProtKB:P48025,ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653,ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739,ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MLLT4_SYK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MLLT4_SYK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MLLT4BCR, RAP1GAP, PVRL1, PFN1, YWHAG, YWHAB, YWHAQ, NRAS, CTNNA1, PVRL2, SSX2IP, LMO2, USP9X, HRAS, RAP1A, EPHB2, EPHB3, EPHB6, EPHA7, NRXN1, NRXN2, NRXN3, JAG1, SORBS1, RIT1, RIN1, SORBS2, TJP1, F11R, PVRL3, RRAS2, KMT2A, MEN1, ARRB2, SIRT7, HNRNPA1, FN1, VCAM1, YWHAE, GRB2, SMAD2, ITGA4, LATS2, LGR4, CUL7, OBSL1, CCDC8, PARK2, FGL1, NCK2, CYP1A1, NAA38, NOTCH2, NR2C2, NTRK1, NUP35, CAPZA2, CDH1, CPNE2, KLHDC3, FGF9, MRPS11, HIF1AN, MTUS2, FUOM, PRICKLE3, CEPT1, TMEM184A, ID2, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, FAM110B, USP21, FAM53C, ANKRD34A, FAM110A, TBC1D25, RAB3IP, CBY1, TRIM25SYKCD79A, CD79B, PTPN6, GRB2, PTK2B, SLA, SH3BP2, LYN, PLCG1, CRKL, LAT, CBL, SRC, VAV1, RPS6KB1, RPS6KB2, SYK, FCGR2A, PRKD1, FCER1G, MS4A2, PAG1, CD72, ITGB2, PTK2, CTTN, FGR, SIRPB1, PXN, TRAF6, PLCG2, TUBA1A, CD3E, CD19, CD22, FCRL3, EPOR, FYN, SIT1, CSF3R, LCK, CD4, CBLB, HDAC1, HDAC3, HDAC6, HDAC9, HDAC2, HDAC4, SP1, CALM1, TUBG1, NEDD4, BLNK, USP25, INPP5D, UBASH3B, LCP2, SEC23B, NCK1, GRAP2, ITGB3, PIK3R2, PIK3R1, RPS10, FCER1A, TYROBP, KLRAP1, SLC4A1, TERF1, TRAIP, PIK3CG, VAV2, BTK, TUBB, MAPT, APP, VCAM1, EGFR, ERBB2, ERBB3, ERBB4, ITGA4, TLR3, TLR4, TLR9, TRAF3, TBK1, MYD88, MAP3K7, TICAM1, FCGR3A, PTPRO, IL17RA, TRAF3IP2, STAT3, SH2D2A, PEAR1, MEGF10, FAM46A, HCLS1, FCGR1A, TRIM15, TNFRSF1A, RHOU, HGS, GRM1, GRASP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MLLT4_SYK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MLLT4_SYK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSYKC0025202melanoma1CTD_human
TgeneSYKC0025500Mesothelioma1CTD_human