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Fusion gene ID: 22171 |
FusionGeneSummary for MLLT3_SYT10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MLLT3_SYT10 | Fusion gene ID: 22171 | Hgene | Tgene | Gene symbol | MLLT3 | SYT10 | Gene ID | 4300 | 341359 |
| Gene name | MLLT3, super elongation complex subunit | synaptotagmin 10 | |
| Synonyms | AF9|YEATS3 | - | |
| Cytomap | 9p21.3 | 12p11.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein AF-9ALL1-fused gene from chromosome 9 proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translo | synaptotagmin-10synaptotagmin XsytX | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P42568 | Q6XYQ8 | |
| Ensembl transtripts involved in fusion gene | ENST00000380338, ENST00000355930, ENST00000429426, ENST00000475957, ENST00000380321, | ENST00000228567, ENST00000535526, ENST00000567656, | |
| Fusion gene scores | * DoF score | 10 X 8 X 8=640 | 3 X 2 X 2=12 |
| # samples | 16 | 3 | |
| ** MAII score | log2(16/640*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MLLT3 [Title/Abstract] AND SYT10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MLLT3 | GO:0045893 | positive regulation of transcription, DNA-templated | 25417107|27105114 |
| Hgene | MLLT3 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 19591803 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-LK-A4O5-01A | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000380338 | ENST00000228567 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5CDS-5UTR | ENST00000380338 | ENST00000535526 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5CDS-intron | ENST00000380338 | ENST00000567656 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5UTR-3CDS | ENST00000355930 | ENST00000228567 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5UTR-5UTR | ENST00000355930 | ENST00000535526 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5UTR-intron | ENST00000355930 | ENST00000567656 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| Frame-shift | ENST00000429426 | ENST00000228567 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5CDS-5UTR | ENST00000429426 | ENST00000535526 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5CDS-intron | ENST00000429426 | ENST00000567656 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5UTR-3CDS | ENST00000475957 | ENST00000228567 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5UTR-5UTR | ENST00000475957 | ENST00000535526 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| 5UTR-intron | ENST00000475957 | ENST00000567656 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| intron-3CDS | ENST00000380321 | ENST00000228567 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| intron-5UTR | ENST00000380321 | ENST00000535526 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
| intron-intron | ENST00000380321 | ENST00000567656 | MLLT3 | chr9 | 20620653 | - | SYT10 | chr12 | 33560291 | - |
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FusionProtFeatures for MLLT3_SYT10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MLLT3 | SYT10 |
| Chromatin reader component of the super elongationcomplex (SEC), a complex required to increase the catalytic rateof RNA polymerase II transcription by suppressing transientpausing by the polymerase at multiple sites along the DNA(PubMed:20159561, PubMed:20471948, PubMed:25417107,PubMed:27105114, PubMed:27545619). Specifically recognizes andbinds acylated histone H3, with a marked preference for histone H3that is crotonylated (PubMed:25417107, PubMed:27105114,PubMed:27545619). Crotonylation marks active promoters andenhancers and confers resistance to transcriptional repressors(PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizesand binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and withslightly lower affinity histone H3 crotonylated at 'Lys-18'(H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3acetylated at 'Lys-9' (H3K9ac), but with lower affinity thancrotonylated histone H3 (PubMed:25417107, PubMed:27105114). In theSEC complex, MLLT3 is required to recruit the complex tocrotonylated histones (PubMed:27105114, PubMed:27545619).{ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948,ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114,ECO:0000269|PubMed:27545619}. | Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 inneurons of the olfactory bulb. Exocytosis of IGF1 is required forsensory perception of smell. Not involved in Ca(2+)-dependentsynaptic vesicle exocytosis (By similarity). Acts through Ca(2+)and phospholipid binding to the C2 domain: Ca(2+) induces bindingof the C2-domains to phospholipid membranes and to assembledSNARE-complexes; both actions contribute to triggering exocytosis(By similarity). {ECO:0000250|UniProtKB:O08625,ECO:0000250|UniProtKB:Q9R0N4}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MLLT3_SYT10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MLLT3_SYT10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MLLT3 | APPBP2, MCM6, BCOR, RBM48, EEF1A1, PTN, LRIF1, DOT1L, SGK1, AFF4, AFF1, CDK9, AFF3, ACACA, SIRT1, CCNT1, NIPBL, EAF1, ELL3, PCGF1, MLLT1, EEF2, ELL, MLLT10, CCNT2, RNF2, KMT2A, CHD4, ELL2, PAF1, APP, CDK6, MED26, HSP90B1, EXOSC3, FAM9A, EDA, DENND2D, EPB41L3, XPO1, H3F3A, PIP4K2A, EPB41L2, CAMKV, MLLT6, SNX24, BPIFB1, MDK, PES1, EPB41L5, ARRB2 | SYT10 | SYT10, SYT6, BOP1, SYT3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MLLT3_SYT10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MLLT3_SYT10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MLLT3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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