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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22165

FusionGeneSummary for MLLT3_DENND4C

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT3_DENND4C
Fusion gene ID: 22165
HgeneTgene
Gene symbol

MLLT3

DENND4C

Gene ID

4300

55667

Gene nameMLLT3, super elongation complex subunitDENN domain containing 4C
SynonymsAF9|YEATS3C9orf55|C9orf55B|RAB10GEF|bA513M16.3
Cytomap

9p21.3

9p22.1

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-9ALL1-fused gene from chromosome 9 proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); transloDENN domain-containing protein 4CDENN/MADD domain containing 4A pseudogeneDENN/MADD domain containing 4C
Modification date2018051920180519
UniProtAcc

P42568

Q5VZ89

Ensembl transtripts involved in fusion geneENST00000380338, ENST00000355930, 
ENST00000429426, ENST00000475957, 
ENST00000380321, 
ENST00000434457, 
ENST00000602925, ENST00000380432, 
Fusion gene scores* DoF score10 X 8 X 8=6402 X 2 X 2=8
# samples 162
** MAII scorelog2(16/640*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MLLT3 [Title/Abstract] AND DENND4C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT3

GO:0045893

positive regulation of transcription, DNA-templated

25417107|27105114

HgeneMLLT3

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591803


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A1Q6-06AMLLT3chr9

20620653

-DENND4Cchr9

19276156

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000380338ENST00000434457MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5CDS-5UTRENST00000380338ENST00000602925MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5CDS-intronENST00000380338ENST00000380432MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5UTR-5UTRENST00000355930ENST00000434457MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5UTR-5UTRENST00000355930ENST00000602925MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5UTR-intronENST00000355930ENST00000380432MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5CDS-5UTRENST00000429426ENST00000434457MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5CDS-5UTRENST00000429426ENST00000602925MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5CDS-intronENST00000429426ENST00000380432MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5UTR-5UTRENST00000475957ENST00000434457MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5UTR-5UTRENST00000475957ENST00000602925MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
5UTR-intronENST00000475957ENST00000380432MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
intron-5UTRENST00000380321ENST00000434457MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
intron-5UTRENST00000380321ENST00000602925MLLT3chr9

20620653

-DENND4Cchr9

19276156

+
intron-intronENST00000380321ENST00000380432MLLT3chr9

20620653

-DENND4Cchr9

19276156

+

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FusionProtFeatures for MLLT3_DENND4C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT3

P42568

DENND4C

Q5VZ89

Chromatin reader component of the super elongationcomplex (SEC), a complex required to increase the catalytic rateof RNA polymerase II transcription by suppressing transientpausing by the polymerase at multiple sites along the DNA(PubMed:20159561, PubMed:20471948, PubMed:25417107,PubMed:27105114, PubMed:27545619). Specifically recognizes andbinds acylated histone H3, with a marked preference for histone H3that is crotonylated (PubMed:25417107, PubMed:27105114,PubMed:27545619). Crotonylation marks active promoters andenhancers and confers resistance to transcriptional repressors(PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizesand binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and withslightly lower affinity histone H3 crotonylated at 'Lys-18'(H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3acetylated at 'Lys-9' (H3K9ac), but with lower affinity thancrotonylated histone H3 (PubMed:25417107, PubMed:27105114). In theSEC complex, MLLT3 is required to recruit the complex tocrotonylated histones (PubMed:27105114, PubMed:27545619).{ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948,ECO:0000269|PubMed:25417107, ECO:0000269|PubMed:27105114,ECO:0000269|PubMed:27545619}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MLLT3_DENND4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MLLT3_DENND4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MLLT3APPBP2, MCM6, BCOR, RBM48, EEF1A1, PTN, LRIF1, DOT1L, SGK1, AFF4, AFF1, CDK9, AFF3, ACACA, SIRT1, CCNT1, NIPBL, EAF1, ELL3, PCGF1, MLLT1, EEF2, ELL, MLLT10, CCNT2, RNF2, KMT2A, CHD4, ELL2, PAF1, APP, CDK6, MED26, HSP90B1, EXOSC3, FAM9A, EDA, DENND2D, EPB41L3, XPO1, H3F3A, PIP4K2A, EPB41L2, CAMKV, MLLT6, SNX24, BPIFB1, MDK, PES1, EPB41L5, ARRB2DENND4CYWHAB, FBXW11, MED4, OFD1, XPO1, CDK8, C1orf112, CDH1, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, CGN, LRFN1, DENND1A, RTKN, SH3PXD2A, MAST3, SRGAP2, EIF4E2, SIPA1L1, PPM1H, LPIN3, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, MAPKAP1, NF1, HDAC4, CBY1, SH3RF3, SRSF12, CDC25C, SYDE1, AGAP1, NADK, GIGYF2, CDC25B, CDK16, TANC2, PTPN13, CAMSAP2, RALGPS2, FAM110B, USP21, KIAA1804, RASAL2, TIAM1, FAM53C, ANKRD34A, OSBPL6, PHLDB2, RPTOR, PLEKHA7, KIF1C, CSNK1A1, MELK, NAV1, DENND4A, FAM110A, GAB2, STARD13, PTPN14, WEE1, INPP5E


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MLLT3_DENND4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MLLT3_DENND4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLLT3C0005586Bipolar Disorder1PSYGENET