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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22143

FusionGeneSummary for MLLT10_ASCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: MLLT10_ASCC1
Fusion gene ID: 22143
HgeneTgene
Gene symbol

MLLT10

ASCC1

Gene ID

8028

51008

Gene nameMLLT10, histone lysine methyltransferase DOT1L cofactoractivating signal cointegrator 1 complex subunit 1
SynonymsAF10ASC1p50|CGI-18|SMABF2|p50
Cytomap

10p12.31

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionprotein AF-10ALL1-fused gene from chromosome 10 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10type I AF10 proteintype III AF10 protactivating signal cointegrator 1 complex subunit 1ASC-1 complex subunit P50trip4 complex subunit p50
Modification date2018052220180520
UniProtAcc

P55197

Q8N9N2

Ensembl transtripts involved in fusion geneENST00000446906, ENST00000377072, 
ENST00000307729, ENST00000377059, 
ENST00000495130, ENST00000377100, 
ENST00000377091, 
ENST00000394919, 
ENST00000342444, ENST00000317168, 
ENST00000545550, ENST00000317126, 
ENST00000394915, ENST00000492502, 
Fusion gene scores* DoF score13 X 10 X 8=10406 X 5 X 4=120
# samples 206
** MAII scorelog2(20/1040*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MLLT10 [Title/Abstract] AND ASCC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMLLT10

GO:0045944

positive regulation of transcription by RNA polymerase II

17868029

TgeneASCC1

GO:0006355

regulation of transcription, DNA-templated

12077347


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-D5-6922-01AMLLT10chr10

21906136

+ASCC1chr10

73892939

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000446906ENST00000394919MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000446906ENST00000342444MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000446906ENST00000317168MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000446906ENST00000545550MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000446906ENST00000317126MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000446906ENST00000394915MLLT10chr10

21906136

+ASCC1chr10

73892939

-
5CDS-intronENST00000446906ENST00000492502MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377072ENST00000394919MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377072ENST00000342444MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377072ENST00000317168MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377072ENST00000545550MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377072ENST00000317126MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377072ENST00000394915MLLT10chr10

21906136

+ASCC1chr10

73892939

-
5CDS-intronENST00000377072ENST00000492502MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000307729ENST00000394919MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000307729ENST00000342444MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000307729ENST00000317168MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000307729ENST00000545550MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000307729ENST00000317126MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000307729ENST00000394915MLLT10chr10

21906136

+ASCC1chr10

73892939

-
5CDS-intronENST00000307729ENST00000492502MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377059ENST00000394919MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377059ENST00000342444MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377059ENST00000317168MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377059ENST00000545550MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377059ENST00000317126MLLT10chr10

21906136

+ASCC1chr10

73892939

-
Frame-shitENST00000377059ENST00000394915MLLT10chr10

21906136

+ASCC1chr10

73892939

-
5CDS-intronENST00000377059ENST00000492502MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000495130ENST00000394919MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000495130ENST00000342444MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000495130ENST00000317168MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000495130ENST00000545550MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000495130ENST00000317126MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000495130ENST00000394915MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-intronENST00000495130ENST00000492502MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377100ENST00000394919MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377100ENST00000342444MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377100ENST00000317168MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377100ENST00000545550MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377100ENST00000317126MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377100ENST00000394915MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-intronENST00000377100ENST00000492502MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377091ENST00000394919MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377091ENST00000342444MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377091ENST00000317168MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377091ENST00000545550MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377091ENST00000317126MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-3CDSENST00000377091ENST00000394915MLLT10chr10

21906136

+ASCC1chr10

73892939

-
intron-intronENST00000377091ENST00000492502MLLT10chr10

21906136

+ASCC1chr10

73892939

-

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FusionProtFeatures for MLLT10_ASCC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MLLT10

P55197

ASCC1

Q8N9N2

Probably involved in transcriptional regulation. Invitro or as fusion protein with KMT2A/MLL1 has transactivationactivity. Binds to cruciform DNA. In cells, binding to unmodifiedhistone H3 regulates DOT1L functions including histone H3 'Lys-79'dimethylation (H3K79me2) and gene activation (PubMed:26439302).{ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:26439302}. Enhances NF-kappa-B, SRF and AP1 transactivation. Incells responding to gastrin-activated paracrine signals, it isinvolved in the induction of SERPINB2 expression by gastrin. Mayalso play a role in the development of neuromuscular junction.{ECO:0000269|PubMed:19074642, ECO:0000269|PubMed:26924529}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MLLT10_ASCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MLLT10_ASCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MLLT10YEATS4, SMARCB1, SS18, MLLT10, DOT1L, MLLT1, MLLT3, AFF1, DISC1, NDEL1, ELAVL1, CENPJ, TMPO, ZNF526, MLLT6, TCP10L, KIF6, PMF1ASCC1NCOA6, ELAVL1, UFSP2, ESR1, EP300, NCOA1, TRAF2, ALKBH3, IGKC, ASCC3, IGHG2, IGHG1, ASCC2, TRIP4, SERPINB3, PNMA2, CPA4, FGB, C3, IGLL5, FGG, CALML5, XPO1, CSNK2A2, SOD1, AURKA, FGFR1OP, SMC6, SKA1, CSRP1, SERPINB4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MLLT10_ASCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MLLT10_ASCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMLLT10C0007134Renal Cell Carcinoma1CTD_human
HgeneMLLT10C0025202melanoma1CTD_human
HgeneMLLT10C0025286Meningioma1CTD_human