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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2214

FusionGeneSummary for APOD_TCFL5

check button Fusion gene summary
Fusion gene informationFusion gene name: APOD_TCFL5
Fusion gene ID: 2214
HgeneTgene
Gene symbol

APOD

TCFL5

Gene ID

347

10732

Gene nameapolipoprotein Dtranscription factor like 5
Synonyms-CHA|E2BP-1|Figlb|SOSF1|bHLHe82
Cytomap

3q29

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionapolipoprotein Dapo-Dtranscription factor-like 5 proteinHPV-16 E2-binding protein 1cha transcription factorspermatogenesis- and oogenesis-specific bHLH-containing protein 1transcription factor-like 5 (basic helix-loop-helix)
Modification date2018052320180523
UniProtAcc

P05090

Q9UL49

Ensembl transtripts involved in fusion geneENST00000343267, ENST00000335351, 
ENST00000217162, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 4=144
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOD [Title/Abstract] AND TCFL5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPOD

GO:0000302

response to reactive oxygen species

18419796

HgeneAPOD

GO:0006006

glucose metabolic process

19176353

HgeneAPOD

GO:0006629

lipid metabolic process

19176353

HgeneAPOD

GO:0010642

negative regulation of platelet-derived growth factor receptor signaling pathway

14551159

HgeneAPOD

GO:0042308

negative regulation of protein import into nucleus

14551159

HgeneAPOD

GO:0048662

negative regulation of smooth muscle cell proliferation

14551159

HgeneAPOD

GO:0060588

negative regulation of lipoprotein lipid oxidation

18419796

HgeneAPOD

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

18842892

HgeneAPOD

GO:1900016

negative regulation of cytokine production involved in inflammatory response

18842892

HgeneAPOD

GO:2000405

negative regulation of T cell migration

18842892

TgeneTCFL5

GO:0000122

negative regulation of transcription by RNA polymerase II

12923186

TgeneTCFL5

GO:0006355

regulation of transcription, DNA-templated

9763657


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DC323743APODchr3

195300743

-TCFL5chr20

61486618

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000343267ENST00000335351APODchr3

195300743

-TCFL5chr20

61486618

-
intron-intronENST00000343267ENST00000217162APODchr3

195300743

-TCFL5chr20

61486618

-

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FusionProtFeatures for APOD_TCFL5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APOD

P05090

TCFL5

Q9UL49

APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in thetransport and binding of bilin. Appears to be able to transport avariety of ligands in a number of different contexts. Putative transcription factor. Isoform 3 may play a rolein early spermatogenesis. {ECO:0000269|PubMed:9763657}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for APOD_TCFL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APOD_TCFL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APOD_TCFL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneAPODP05090DB00162Vitamin AApolipoprotein Dsmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for APOD_TCFL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPODC0036341Schizophrenia3PSYGENET
HgeneAPODC0005586Bipolar Disorder1PSYGENET
HgeneAPODC0017638Glioma1CTD_human
HgeneAPODC0023186Learning Disorders1CTD_human
HgeneAPODC0086439Hypokinesia1CTD_human
HgeneAPODC0524851Neurodegenerative Disorders1CTD_human