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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22118

FusionGeneSummary for MKRN1_NLGN1

check button Fusion gene summary
Fusion gene informationFusion gene name: MKRN1_NLGN1
Fusion gene ID: 22118
HgeneTgene
Gene symbol

MKRN1

NLGN1

Gene ID

23608

22871

Gene namemakorin ring finger protein 1neuroligin 1
SynonymsRNF61NL1
Cytomap

7q34

3q26.31

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase makorin-1RING finger protein 61RING-type E3 ubiquitin transferase makorin-1neuroligin-1
Modification date2018052220180523
UniProtAcc

Q9UHC7

Q8N2Q7

Ensembl transtripts involved in fusion geneENST00000255977, ENST00000437223, 
ENST00000474576, ENST00000480552, 
ENST00000443720, ENST00000481705, 
ENST00000457714, ENST00000361589, 
ENST00000401917, ENST00000545397, 
ENST00000466350, 
Fusion gene scores* DoF score6 X 6 X 7=2528 X 3 X 7=168
# samples 88
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MKRN1 [Title/Abstract] AND NLGN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKRN1

GO:0000209

protein polyubiquitination

19536131

TgeneNLGN1

GO:0031175

neuron projection development

22750515

TgeneNLGN1

GO:0051965

positive regulation of synapse assembly

24613359


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A23R-01AMKRN1chr7

140171683

-NLGN1chr3

173993105

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000255977ENST00000457714MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000255977ENST00000361589MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000255977ENST00000401917MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000255977ENST00000545397MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5CDS-3UTRENST00000255977ENST00000466350MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000437223ENST00000457714MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000437223ENST00000361589MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000437223ENST00000401917MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000437223ENST00000545397MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3UTRENST00000437223ENST00000466350MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000474576ENST00000457714MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000474576ENST00000361589MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000474576ENST00000401917MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000474576ENST00000545397MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5CDS-3UTRENST00000474576ENST00000466350MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000480552ENST00000457714MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000480552ENST00000361589MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000480552ENST00000401917MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000480552ENST00000545397MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5CDS-3UTRENST00000480552ENST00000466350MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000443720ENST00000457714MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000443720ENST00000361589MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000443720ENST00000401917MKRN1chr7

140171683

-NLGN1chr3

173993105

+
Frame-shiftENST00000443720ENST00000545397MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5CDS-3UTRENST00000443720ENST00000466350MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000481705ENST00000457714MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000481705ENST00000361589MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000481705ENST00000401917MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3CDSENST00000481705ENST00000545397MKRN1chr7

140171683

-NLGN1chr3

173993105

+
5UTR-3UTRENST00000481705ENST00000466350MKRN1chr7

140171683

-NLGN1chr3

173993105

+

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FusionProtFeatures for MKRN1_NLGN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKRN1

Q9UHC7

NLGN1

Q8N2Q7

Cell surface protein involved in cell-cell-interactionsvia its interactions with neurexin family members. Plays a role insynapse function and synaptic signal transmission, and probablymediates its effects by recruiting and clustering other synapticproteins. May promote the initial formation of synapses, but isnot essential for this. In vitro, triggers the de novo formationof presynaptic structures. May be involved in specification ofexcitatory synapses. Required to maintain wakefulness quality andnormal synchrony of cerebral cortex activity during wakefulnessand sleep. {ECO:0000250|UniProtKB:Q99K10}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MKRN1_NLGN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MKRN1_NLGN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MKRN1TERT, CSNK1G1, DUSP23, MAP1LC3B, UBE2D3, UBE2W, FADD, TP53, CDKN1A, EXOSC8, TRA2A, LUC7L, LUC7L2, SNIP1, IGF2BP1, ELAVL1, PABPC1, SNRNP70, GLTSCR2, RRS1, CELF3, RBFOX1NLGN1NRXN1, DLG4, DLG3, DLG2, NRXN2, NRXN3, NLGN3, B3GAT3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MKRN1_NLGN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MKRN1_NLGN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNLGN1C0004352Autistic Disorder1CTD_human
TgeneNLGN1C0005586Bipolar Disorder1PSYGENET
TgeneNLGN1C0036341Schizophrenia1PSYGENET