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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22111

FusionGeneSummary for MKNK2_UBAC2

check button Fusion gene summary
Fusion gene informationFusion gene name: MKNK2_UBAC2
Fusion gene ID: 22111
HgeneTgene
Gene symbol

MKNK2

UBAC2

Gene ID

2872

337867

Gene nameMAP kinase interacting serine/threonine kinase 2UBA domain containing 2
SynonymsGPRK7|MNK2PHGDHL1
Cytomap

19p13.3

13q32.3

Type of geneprotein-codingprotein-coding
DescriptionMAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase signal-integrating kinase 2MAPK signal-integrating kinase 2ubiquitin-associated domain-containing protein 2RP11-178C10.1UBA domain-containing protein 2phosphoglycerate dehydrogenase like 1phosphoglycerate dehydrogenase-like protein 1
Modification date2018052320180519
UniProtAcc

Q9HBH9

Q8NBM4

Ensembl transtripts involved in fusion geneENST00000591142, ENST00000591601, 
ENST00000309340, ENST00000250896, 
ENST00000541165, ENST00000591588, 
ENST00000588014, 
ENST00000403766, 
ENST00000376440, ENST00000460562, 
Fusion gene scores* DoF score7 X 7 X 4=1967 X 6 X 4=168
# samples 77
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MKNK2 [Title/Abstract] AND UBAC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKNK2

GO:0006468

protein phosphorylation

11463832

HgeneMKNK2

GO:0030097

hemopoiesis

21149447

HgeneMKNK2

GO:0035556

intracellular signal transduction

11463832

HgeneMKNK2

GO:0071243

cellular response to arsenic-containing substance

18299328

TgeneUBAC2

GO:0070972

protein localization to endoplasmic reticulum

23297223


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM765288MKNK2chr19

2038030

-UBAC2chr13

100037910

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000591142ENST00000403766MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000591142ENST00000376440MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000591142ENST00000460562MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-intronENST00000591601ENST00000403766MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000591601ENST00000376440MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000591601ENST00000460562MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-intronENST00000309340ENST00000403766MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000309340ENST00000376440MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000309340ENST00000460562MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-intronENST00000250896ENST00000403766MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000250896ENST00000376440MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000250896ENST00000460562MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-intronENST00000541165ENST00000403766MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000541165ENST00000376440MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000541165ENST00000460562MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-intronENST00000591588ENST00000403766MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000591588ENST00000376440MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000591588ENST00000460562MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-intronENST00000588014ENST00000403766MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000588014ENST00000376440MKNK2chr19

2038030

-UBAC2chr13

100037910

+
intron-3UTRENST00000588014ENST00000460562MKNK2chr19

2038030

-UBAC2chr13

100037910

+

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FusionProtFeatures for MKNK2_UBAC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKNK2

Q9HBH9

UBAC2

Q8NBM4

Serine/threonine-protein kinase that phosphorylatesSFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response toenvironmental stress and cytokines. Appears to regulatetranslation by phosphorylating EIF4E, thus increasing the affinityof this protein for the 7-methylguanosine-containing mRNA cap.Required for mediating PP2A-inhibition-induced EIF4Ephosphorylation. Triggers EIF4E shuttling from cytoplasm tonucleus. Isoform 1 displays a high basal kinase activity, butisoform 2 exhibits a very low kinase activity. Acts as a mediatorof the suppressive effects of IFNgamma on hematopoiesis. Negativeregulator for signals that control generation of arsenic trioxideAs(2)O(3)-dependent apoptosis and anti-leukemic responses.Involved in anti-apoptotic signaling in response to serumwithdrawal. {ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:12897141,ECO:0000269|PubMed:16111636, ECO:0000269|PubMed:17965020,ECO:0000269|PubMed:18299328, ECO:0000269|PubMed:20823271,ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:21149447}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MKNK2_UBAC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MKNK2_UBAC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MKNK2_UBAC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MKNK2_UBAC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource