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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22099

FusionGeneSummary for MKLN1_GRM8

check button Fusion gene summary
Fusion gene informationFusion gene name: MKLN1_GRM8
Fusion gene ID: 22099
HgeneTgene
Gene symbol

MKLN1

GRM8

Gene ID

4289

2918

Gene namemuskelin 1glutamate metabotropic receptor 8
SynonymsTWA2GLUR8|GPRC1H|MGLUR8|mGlu8
Cytomap

7q32.3

7q31.33

Type of geneprotein-codingprotein-coding
Descriptionmuskelinmuskelin 1, intracellular mediator containing kelch motifsmetabotropic glutamate receptor 8glutamate receptor, metabotropic 8
Modification date2018052220180523
UniProtAcc

Q9UL63

O00222

Ensembl transtripts involved in fusion geneENST00000421797, ENST00000429546, 
ENST00000352689, ENST00000498778, 
ENST00000444921, ENST00000339582, 
ENST00000358373, ENST00000405249, 
ENST00000480995, 
Fusion gene scores* DoF score9 X 9 X 6=4867 X 7 X 6=294
# samples 98
** MAII scorelog2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/294*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MKLN1 [Title/Abstract] AND GRM8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRM8

GO:0007193

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

11166323


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EE-A20I-06AMKLN1chr7

131096142

+GRM8chr7

126883569

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000421797ENST00000444921MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-5UTRENST00000421797ENST00000339582MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-5UTRENST00000421797ENST00000358373MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-intronENST00000421797ENST00000405249MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-intronENST00000421797ENST00000480995MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-3CDSENST00000429546ENST00000444921MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-5UTRENST00000429546ENST00000339582MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-5UTRENST00000429546ENST00000358373MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-intronENST00000429546ENST00000405249MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-intronENST00000429546ENST00000480995MKLN1chr7

131096142

+GRM8chr7

126883569

-
Frame-shiftENST00000352689ENST00000444921MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-5UTRENST00000352689ENST00000339582MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-5UTRENST00000352689ENST00000358373MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-intronENST00000352689ENST00000405249MKLN1chr7

131096142

+GRM8chr7

126883569

-
5CDS-intronENST00000352689ENST00000480995MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-3CDSENST00000498778ENST00000444921MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-5UTRENST00000498778ENST00000339582MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-5UTRENST00000498778ENST00000358373MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-intronENST00000498778ENST00000405249MKLN1chr7

131096142

+GRM8chr7

126883569

-
intron-intronENST00000498778ENST00000480995MKLN1chr7

131096142

+GRM8chr7

126883569

-

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FusionProtFeatures for MKLN1_GRM8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKLN1

Q9UL63

GRM8

O00222

Acts as a mediator of cell spreading and cytoskeletalresponses to the extracellular matrix component THBS1.{ECO:0000250|UniProtKB:O89050}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MKLN1_GRM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MKLN1_GRM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MKLN1RNPS1, MYC, RANBP9, ELAVL1, MKLN1, MAEA, GID8, RMND5A, SOX2, PTGER3, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, GGH, MRPL4, GPS2, NR1H3, HLA-DPB1, ADCYAP1, PRG2, IFI30, UNK, DYNC1H1, BMP1, PRG3, INSL6, PIGT, CCDC120, TIGD5, SUCLA2, NFATC1, LILRB4, CARKD, IKZF1, C4orf27, TLE4, ARMC8, ZMYND19, GID4, HTRA2, WDR26, PMFBP1, AAMP, MMADHC, HSPBP1, LONP1, RSPH10B, NDUFS2, SOAT1, RMND5B, YPEL5, RANBP10, RAB8A, TRIM25GRM8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MKLN1_GRM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRM8O00222DB00142Glutamic AcidMetabotropic glutamate receptor 8small moleculeapproved|nutraceutical

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RelatedDiseases for MKLN1_GRM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRM8C0036341Schizophrenia3PSYGENET
TgeneGRM8C0001957Alcohol Withdrawal Delirium1PSYGENET
TgeneGRM8C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGRM8C0003469Anxiety Disorders1CTD_human
TgeneGRM8C0004352Autistic Disorder1CTD_human
TgeneGRM8C0017639Gliosis1CTD_human
TgeneGRM8C0149925Small cell carcinoma of lung1CTD_human
TgeneGRM8C1263846Attention deficit hyperactivity disorder1CTD_human