FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 22073

FusionGeneSummary for MKL1_NTNG1

check button Fusion gene summary
Fusion gene informationFusion gene name: MKL1_NTNG1
Fusion gene ID: 22073
HgeneTgene
Gene symbol

MKL1

NTNG1

Gene ID

57591

84628

Gene namemegakaryoblastic leukemia (translocation) 1netrin G2
SynonymsBSAC|MAL|MKL|MRTF-ALHLL9381|Lmnt2|NTNG1|bA479K20.1
Cytomap

22q13.1-q13.2

9q34.13

Type of geneprotein-codingprotein-coding
DescriptionMKL/myocardin-like protein 1basic, SAP and coiled-coil domainmegakaryoblastic leukemia 1 proteinmegakaryocytic acute leukemia proteinmyocardin-related transcription factor Anetrin-G2bA479K20.1 (novel protein)laminet 2netrin G1
Modification date2018052420180522
UniProtAcc

Q969V6

Q9Y2I2

Ensembl transtripts involved in fusion geneENST00000355630, ENST00000396617, 
ENST00000402042, ENST00000466278, 
ENST00000407029, ENST00000402630, 
ENST00000370073, ENST00000370071, 
ENST00000370074, ENST00000370070, 
ENST00000370061, ENST00000370072, 
ENST00000542803, ENST00000370068, 
ENST00000370067, ENST00000370065, 
ENST00000370066, ENST00000477948, 
Fusion gene scores* DoF score19 X 11 X 13=27175 X 4 X 4=80
# samples 265
** MAII scorelog2(26/2717*10)=-3.38543103719352
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MKL1 [Title/Abstract] AND NTNG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKL1

GO:0010735

positive regulation of transcription via serum response element binding

24440334

HgeneMKL1

GO:0045944

positive regulation of transcription by RNA polymerase II

14970199


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-69-7979-01AMKL1chr22

41032482

-NTNG1chr1

107937776

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000355630ENST00000370073MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370071MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370074MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370070MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370061MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370072MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000542803MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370068MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370067MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370065MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000355630ENST00000370066MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-intronENST00000355630ENST00000477948MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370073MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370071MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370074MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370070MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370061MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370072MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000542803MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370068MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370067MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370065MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000396617ENST00000370066MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-intronENST00000396617ENST00000477948MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370073MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370071MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370074MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370070MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370061MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370072MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000542803MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370068MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370067MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370065MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000402042ENST00000370066MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-intronENST00000402042ENST00000477948MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370073MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370071MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370074MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370070MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370061MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370072MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000542803MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370068MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370067MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370065MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-3CDSENST00000466278ENST00000370066MKL1chr22

41032482

-NTNG1chr1

107937776

+
5UTR-intronENST00000466278ENST00000477948MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370073MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370071MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370074MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370070MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370061MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370072MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000542803MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370068MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370067MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370065MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000407029ENST00000370066MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-intronENST00000407029ENST00000477948MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370073MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370071MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370074MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370070MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370061MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370072MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000542803MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370068MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370067MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370065MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-3CDSENST00000402630ENST00000370066MKL1chr22

41032482

-NTNG1chr1

107937776

+
intron-intronENST00000402630ENST00000477948MKL1chr22

41032482

-NTNG1chr1

107937776

+

Top

FusionProtFeatures for MKL1_NTNG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKL1

Q969V6

NTNG1

Q9Y2I2

Transcriptional coactivator of serum response factor(SRF) with the potential to modulate SRF target genes. SuppressesTNF-induced cell death by inhibiting activation of caspases; itstranscriptional activity is indispensable for the antiapoptoticfunction. It may up-regulate antiapoptotic molecules, which inturn inhibit caspase activation (By similarity). {ECO:0000250}. Involved in controlling patterning and neuronal circuitformation at the laminar, cellular, subcellular and synapticlevels. Promotes neurite outgrowth of both axons and dendrites.{ECO:0000269|PubMed:21946559}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MKL1_NTNG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MKL1_NTNG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MKL1MYOCD, SRF, MKL2, SUPT16H, SSRP1, KDM3A, SMARCA4, GSK3B, SMAD3, ACTB, MVP, NXF1, NCOA3, KIAA0753, CEP63, CEP19, LCA5, RPGRIP1, TCTN1, XPO1, DNMT1, EP300, BCL7A, TRIM25NTNG1LRRC4C, HSPA6, GAS6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MKL1_NTNG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MKL1_NTNG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNTNG1C0005586Bipolar Disorder1CTD_human
TgeneNTNG1C0009404Colorectal Neoplasms1CTD_human
TgeneNTNG1C0036341Schizophrenia1CTD_human