|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 2207 |
FusionGeneSummary for APOC1_IQCE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: APOC1_IQCE | Fusion gene ID: 2207 | Hgene | Tgene | Gene symbol | APOC1 | IQCE | Gene ID | 341 | 23288 |
| Gene name | apolipoprotein C1 | IQ motif containing E | |
| Synonyms | Apo-CI|ApoC-I|apo-CIB|apoC-IB | 1700028P05Rik|PAPA7 | |
| Cytomap | 19q13.32 | 7p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apolipoprotein C-I | IQ domain-containing protein E | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P02654 | Q6IPM2 | |
| Ensembl transtripts involved in fusion gene | ENST00000588750, ENST00000588802, ENST00000252491, ENST00000592885, ENST00000589781, ENST00000586638, | ENST00000404984, ENST00000402050, ENST00000438376, ENST00000325979, ENST00000497572, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 12 X 3 X 9=324 |
| # samples | 4 | 12 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/324*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: APOC1 [Title/Abstract] AND IQCE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | APOC1 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process | 2302419 |
| Hgene | APOC1 | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance | 1917954 |
| Hgene | APOC1 | GO:0032375 | negative regulation of cholesterol transport | 10978346 |
| Hgene | APOC1 | GO:0033344 | cholesterol efflux | 11162594 |
| Hgene | APOC1 | GO:0033700 | phospholipid efflux | 11162594 |
| Hgene | APOC1 | GO:0034369 | plasma lipoprotein particle remodeling | 10978346 |
| Hgene | APOC1 | GO:0034382 | chylomicron remnant clearance | 4020294 |
| Hgene | APOC1 | GO:0045717 | negative regulation of fatty acid biosynthetic process | 15576844 |
| Hgene | APOC1 | GO:0045833 | negative regulation of lipid metabolic process | 182536 |
| Hgene | APOC1 | GO:0048261 | negative regulation of receptor-mediated endocytosis | 1917954 |
| Hgene | APOC1 | GO:0050995 | negative regulation of lipid catabolic process | 15576844 |
| Hgene | APOC1 | GO:0051005 | negative regulation of lipoprotein lipase activity | 15576844 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-A4P7-01A | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000588750 | ENST00000404984 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| intron-3CDS | ENST00000588750 | ENST00000402050 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| intron-3CDS | ENST00000588750 | ENST00000438376 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| intron-3CDS | ENST00000588750 | ENST00000325979 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| intron-intron | ENST00000588750 | ENST00000497572 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000588802 | ENST00000404984 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000588802 | ENST00000402050 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000588802 | ENST00000438376 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000588802 | ENST00000325979 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| 5CDS-intron | ENST00000588802 | ENST00000497572 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000252491 | ENST00000404984 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000252491 | ENST00000402050 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000252491 | ENST00000438376 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000252491 | ENST00000325979 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| 5CDS-intron | ENST00000252491 | ENST00000497572 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000592885 | ENST00000404984 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000592885 | ENST00000402050 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000592885 | ENST00000438376 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000592885 | ENST00000325979 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| 5CDS-intron | ENST00000592885 | ENST00000497572 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000589781 | ENST00000404984 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000589781 | ENST00000402050 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000589781 | ENST00000438376 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| Frame-shift | ENST00000589781 | ENST00000325979 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| 5CDS-intron | ENST00000589781 | ENST00000497572 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| In-frame | ENST00000586638 | ENST00000404984 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| In-frame | ENST00000586638 | ENST00000402050 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| In-frame | ENST00000586638 | ENST00000438376 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| In-frame | ENST00000586638 | ENST00000325979 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
| 5CDS-intron | ENST00000586638 | ENST00000497572 | APOC1 | chr19 | 45422606 | + | IQCE | chr7 | 2641075 | + |
Top |
FusionProtFeatures for APOC1_IQCE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| APOC1 | IQCE |
| Inhibitor of lipoprotein binding to the low densitylipoprotein (LDL) receptor, LDL receptor-related protein, and verylow density lipoprotein (VLDL) receptor. Associates with highdensity lipoproteins (HDL) and the triacylglycerol-richlipoproteins in the plasma and makes up about 10% of the proteinof the VLDL and 2% of that of HDL. Appears to interfere directlywith fatty acid uptake and is also the major plasma inhibitor ofcholesteryl ester transfer protein (CETP). Binds free fatty acidsand reduces their intracellular esterification. Modulates theinteraction of APOE with beta-migrating VLDL and inhibits bindingof beta-VLDL to the LDL receptor-related protein.{ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}. | Component of the EvC complex that positively regulatesciliary Hedgehog (Hh) signaling. {ECO:0000250|UniProtKB:Q6PCQ0}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for APOC1_IQCE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000404984_chr7_2641075_+_294aa MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSELSAKMRLEPFPGHGRAGGVVFRDISESEGET QDXLMRTXRVTSQEGPLKFPTPQRLCXGLPPCGPRCHQXKSYRKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQS SPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGD >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000402050_chr7_2641075_+_294aa MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSELSAKMRLEPFPGHGRAGGVVFRDISESEGET QDXLMRTXRVTSQEGPLKFPTPQRLCXGLPPCGPRCHQXKSYRKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQS SPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGD >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000438376_chr7_2641075_+_294aa MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSELSAKMRLEPFPGHGRAGGVVFRDISESEGET QDXLMRTXRVTSQEGPLKFPTPQRLCXGLPPCGPRCHQXKSYRKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQS SPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGD >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000325979_chr7_2641075_+_294aa MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSELSAKMRLEPFPGHGRAGGVVFRDISESEGET QDXLMRTXRVTSQEGPLKFPTPQRLCXGLPPCGPRCHQXKSYRKKKKAVLDEAAVVLQAAFRGHLTRTKLLASKAHGSEPPSVPGLPDQS SPVPRVPSPIAQATGSPVQEEAIVIIQSALRAHLARARHSATGKRTTTAASTRRRSASATHGDASSPPFLAALPDPSPSGPQALAPLPGD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000404984_chr7_2641075_+_882nt ATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCCCAGCCCAGGGGACCCCAGACGTC TCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCAGCCGCATCAAACAGAGTGAACTT TCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACATTTCAGAAAGTGAAGGAGAAACT CAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCCAGCGCCTGTGCTGAGGACTCCCT CCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCT TTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGC TCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTG CGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACA CACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGAT >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000402050_chr7_2641075_+_882nt ATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCCCAGCCCAGGGGACCCCAGACGTC TCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCAGCCGCATCAAACAGAGTGAACTT TCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACATTTCAGAAAGTGAAGGAGAAACT CAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCCAGCGCCTGTGCTGAGGACTCCCT CCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCT TTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGC TCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTG CGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACA CACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGAT >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000438376_chr7_2641075_+_882nt ATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCCCAGCCCAGGGGACCCCAGACGTC TCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCAGCCGCATCAAACAGAGTGAACTT TCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACATTTCAGAAAGTGAAGGAGAAACT CAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCCAGCGCCTGTGCTGAGGACTCCCT CCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCT TTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGC TCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTG CGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACA CACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGAT >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000325979_chr7_2641075_+_882nt ATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCCCAGCCCAGGGGACCCCAGACGTC TCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCAGCCGCATCAAACAGAGTGAACTT TCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACATTTCAGAAAGTGAAGGAGAAACT CAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCCAGCGCCTGTGCTGAGGACTCCCT CCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCT TTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGC TCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTG CGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACA CACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000404984_chr7_2641075_+_5476nt CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG TTTAGGTCCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGCCGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGG AGAAGAACGATGATACCTACTTAACACCTCAGCATCTGCGTCGTGTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTAC TTTATTCTCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTCCAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCT GCCGTGAACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTCTCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGC TGCTATCCGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGTGACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCC AGGCAGACACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGCTTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAG GAGCTAAAGACACCCAGGTCCCCAAATGATCTTACTCCATGCCCCACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGA GCACTGCCCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTGGATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTAC AAAAGCAGCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTCTGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCC GGGGAAGAGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTCCAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTC TGGGACAGTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCCAAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGG CGTGCGGAGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGGAGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTG TGTGTGAGATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTTAGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCA GGCCTGGTGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTGCCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCC CCTTTTTACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACGGGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCT TCTGAGTCACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTCAGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGG AGGCTCTGCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTGTCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCA CCCAAAGTGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGCCCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGT CAGCGGGGGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCTGTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAAC TTGATGGACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGCCTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAG CCATCCCTGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAGTCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTG GGGGAGACCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTAAACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGG CCTAGAGCTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTCAGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGG TGCAGCTGGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGCTCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTG ATGCCCAGTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTACAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTT TTGTTCCATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCACGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTT AGGCAGGAGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGG CGAGCTGTGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAATGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCAT GGGAAAGGTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGG CCTAGCCATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGGGAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGC TGGCAGGGCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGTAGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTG CCAAAGCAGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGCAGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACAT CACCTTGAACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCAGAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTA TCCCATGCCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCCAGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTG ACACTGCTGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAGCCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTC CCCAACTCCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCTCAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATA CAGGAGGCTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTTGTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGA GAAAGAGGAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGCCGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGT CCCTTGGTTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCAGGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGC AGAAGTGAGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGGGGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATG CCAGAGAGGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGGGTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCAC CAAGACCACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGAGACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCC GGTGTTGGACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTATTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTG GCTGTGGTCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAGACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCC TTCCTTGCAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCAACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCA TTTTTGAGGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAAGATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAAT TCCTCCTTTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCGGATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGT CCGAGCCAGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCAAGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGT ACAGACCACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGACGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGG AAGGAGTGGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTATTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATA >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000402050_chr7_2641075_+_5477nt CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG TTTAGGTCCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGCCGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGG AGAAGAACGATGATACCTACTTAACACCTCAGCATCTGCGTCGTGTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTAC TTTATTCTCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTCCAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCT GCCGTGAACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTCTCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGC TGCTATCCGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGTGACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCC AGGCAGACACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGCTTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAG GAGCTAAAGACACCCAGGTCCCCAAATGATCTTACTCCATGCCCCACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGA GCACTGCCCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTGGATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTAC AAAAGCAGCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTCTGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCC GGGGAAGAGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTCCAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTC TGGGACAGTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCCAAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGG CGTGCGGAGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGGAGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTG TGTGTGAGATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTTAGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCA GGCCTGGTGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTGCCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCC CCTTTTTACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACGGGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCT TCTGAGTCACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTCAGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGG AGGCTCTGCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTGTCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCA CCCAAAGTGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGCCCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGT CAGCGGGGGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCTGTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAAC TTGATGGACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGCCTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAG CCATCCCTGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAGTCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTG GGGGAGACCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTAAACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGG CCTAGAGCTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTCAGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGG TGCAGCTGGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGCTCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTG ATGCCCAGTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTACAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTT TTGTTCCATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCACGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTT AGGCAGGAGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGG CGAGCTGTGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAATGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCAT GGGAAAGGTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGAGCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGG CCTAGCCATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGGGAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGC TGGCAGGGCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGTAGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTG CCAAAGCAGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGCAGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACAT CACCTTGAACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCAGAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTA TCCCATGCCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCCAGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTG ACACTGCTGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAGCCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTC CCCAACTCCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCTCAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATA CAGGAGGCTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTTGTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGA GAAAGAGGAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGCCGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGT CCCTTGGTTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCAGGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGC AGAAGTGAGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGGGGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATG CCAGAGAGGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGGGTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCAC CAAGACCACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGAGACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCC GGTGTTGGACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTATTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTG GCTGTGGTCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAGACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCC TTCCTTGCAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCAACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCA TTTTTGAGGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAAGATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAAT TCCTCCTTTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCGGATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGT CCGAGCCAGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCAAGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGT ACAGACCACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGACGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGG AAGGAGTGGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTATTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATA >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000438376_chr7_2641075_+_905nt CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG >In-frame_APOC1_ENST00000586638_chr19_45422606_+_IQCE_ENST00000325979_chr7_2641075_+_905nt CAGAGTGCCCCTCCGGCCTCGCCATGAGGCTCTTCCTGTCGCTCCCGGTCCTGGTGGTGGTTCTGTCGATCGTCTTGGAAGGCCCAGCCC CAGCCCAGGGGACCCCAGACGTCTCCAGTGCCTTGGATAAGCTGAAGGAGTTTGGAAACACACTGGAGGACAAGGCTCGGGAACTCATCA GCCGCATCAAACAGAGTGAACTTTCTGCCAAGATGCGGTTAGAACCCTTCCCAGGGCACGGGAGAGCTGGGGGAGTGGTTTTCAGAGACA TTTCAGAAAGTGAAGGAGAAACTCAAGATTGACTCATGAGGACCTGAAGGGTGACATCCCAGGAGGGGCCTCTGAAATTTCCCACACCCC AGCGCCTGTGCTGAGGACTCCCTCCATGTGGCCCCAGGTGCCACCAATAAAAATCCTACAGAAAAAAAAAAAAGGCTGTTCTGGATGAGG CGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGGACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCG TGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCGAGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCA TCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCCAGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCA GGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCACCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGG CCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCCGACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAG |
Top |
FusionGenePPI for APOC1_IQCE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| APOC1 | APOA1, HMP19, VKORC1, ALB | IQCE | CARD9, CEP70, GOLGA2, HOOK2, LZTS2, MTUS2, RPGRIP1, SPAG5, TRIM23, TRIM27, TTC23L, PSMA3, CALM2, CALM3, RFFL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for APOC1_IQCE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for APOC1_IQCE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | APOC1 | C0018801 | Heart failure | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|