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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22061

FusionGeneSummary for MKI67_SORBS1

check button Fusion gene summary
Fusion gene informationFusion gene name: MKI67_SORBS1
Fusion gene ID: 22061
HgeneTgene
Gene symbol

MKI67

SORBS1

Gene ID

4288

10580

Gene namemarker of proliferation Ki-67sorbin and SH3 domain containing 1
SynonymsKIA|MIB-|MIB-1|PPP1R105CAP|FLAF2|R85FL|SH3D5|SH3P12|SORB1
Cytomap

10q26.2

10q24.1

Type of geneprotein-codingprotein-coding
Descriptionproliferation marker protein Ki-67antigen Ki67antigen identified by monoclonal antibody Ki-67proliferation-related Ki-67 antigenprotein phosphatase 1, regulatory subunit 105sorbin and SH3 domain-containing protein 1Fas-ligand associated factor 2SH3 domain protein 5c-Cbl associated proteinponsin
Modification date2018052720180519
UniProtAcc

P46013

Q9BX66

Ensembl transtripts involved in fusion geneENST00000368653, ENST00000368654, 
ENST00000484853, 		ENST00000371227, 
ENST00000371249, ENST00000306402, 
ENST00000353505, ENST00000371246, 
ENST00000347291, ENST00000393949, 
ENST00000371247, ENST00000607232, 
ENST00000371245, ENST00000361941, 
ENST00000277982, ENST00000354106, 
ENST00000371239, ENST00000371241, 
ENST00000474353, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 13 X 6=702
# samples 116
** MAII scorelog2(1/1*10)=3.32192809488736log2(16/702*10)=-2.1333991254172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MKI67 [Title/Abstract] AND SORBS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMKI67

GO:0007088

regulation of mitotic nuclear division

27362226

HgeneMKI67

GO:0051983

regulation of chromosome segregation

27362226


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW361227MKI67chr10

129899686

+SORBS1chr10

97153945

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000368653ENST00000371227MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000371249MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000306402MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000353505MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000371246MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000347291MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000393949MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000371247MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000607232MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000371245MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000361941MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000277982MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000354106MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000371239MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000371241MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368653ENST00000474353MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000371227MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000371249MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000306402MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000353505MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000371246MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000347291MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000393949MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000371247MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000607232MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000371245MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000361941MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000277982MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000354106MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000371239MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000371241MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000368654ENST00000474353MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000371227MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000371249MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000306402MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000353505MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000371246MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000347291MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000393949MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000371247MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000607232MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000371245MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000361941MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000277982MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000354106MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000371239MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000371241MKI67chr10

129899686

+SORBS1chr10

97153945

+
intron-intronENST00000484853ENST00000474353MKI67chr10

129899686

+SORBS1chr10

97153945

+

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FusionProtFeatures for MKI67_SORBS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MKI67

P46013

SORBS1

Q9BX66

Required to maintain individual mitotic chromosomesdispersed in the cytoplasm following nuclear envelope disassembly(PubMed:27362226). Associates with the surface of the mitoticchromosome, the perichromosomal layer, and covers a substantialfraction of the chromosome surface (PubMed:27362226). Preventschromosomes from collapsing into a single chromatin mass byforming a steric and electrostatic charge barrier: the protein hasa high net electrical charge and acts as a surfactant, dispersingchromosomes and enabling independent chromosome motility(PubMed:27362226). Binds DNA, with a preference for supercoiledDNA and AT-rich DNA (PubMed:10878551). Does not contribute to theinternal structure of mitotic chromosomes (By similarity). Mayplay a role in chromatin organization (PubMed:24867636). It ishowever unclear whether it plays a direct role in chromatinorganization or whether it is an indirect consequence of itsfunction in maintaining mitotic chromosomes dispersed (Probable).{ECO:0000250|UniProtKB:E9PVX6, ECO:0000269|PubMed:10878551,ECO:0000269|PubMed:24867636, ECO:0000269|PubMed:27362226}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MKI67_SORBS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MKI67_SORBS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MKI67_SORBS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MKI67_SORBS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMKI67C1458155Mammary Neoplasms3CTD_human
HgeneMKI67C0001418Adenocarcinoma1CTD_human
HgeneMKI67C0009375Colonic Neoplasms1CTD_human
HgeneMKI67C0009404Colorectal Neoplasms1CTD_human
HgeneMKI67C0019189Hepatitis, Chronic1CTD_human
HgeneMKI67C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMKI67C0031117Peripheral Neuropathy1CTD_human
HgeneMKI67C0033860Psoriasis1CTD_human
HgeneMKI67C0206637Chondrosarcoma, Mesenchymal1CTD_human
HgeneMKI67C0919267ovarian neoplasm1CTD_human
HgeneMKI67C1876165Copper-Overload Cirrhosis1CTD_human