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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 22040

FusionGeneSummary for MIR548N_MIR548N

check button Fusion gene summary
Fusion gene informationFusion gene name: MIR548N_MIR548N
Fusion gene ID: 22040
HgeneTgene
Gene symbol

MIR548N

MIR548N

Gene ID

100302152

100302152

Gene namemicroRNA 548nmicroRNA 548n
SynonymsMIRN548N|hsa-mir-548nMIRN548N|hsa-mir-548n
Cytomap

7p14.2

7p14.2

Type of genencRNAncRNA
Description--
Modification date2018032920180329
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000408742, ENST00000408742, 
Fusion gene scores* DoF score10 X 14 X 1=1404 X 8 X 1=32
# samples 168
** MAII scorelog2(16/140*10)=0.192645077942396
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/32*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MIR548N [Title/Abstract] AND MIR548N [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1F00809MIR548Nchr2

179453674

+MIR548Nchr2

179453399

-
ChiTaRS3.1F00536MIR548Nchr2

179416978

-MIR548Nchr2

179453312

+
ChiTaRS3.1Z24856MIR548Nchr2

179417481

+MIR548Nchr2

179417547

-
ChiTaRS3.1AA194306MIR548Nchr2

179414774

-MIR548Nchr2

179414087

+
ChiTaRS3.1BF750194MIR548Nchr2

179435304

-MIR548Nchr2

179435166

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000408742ENST00000408742MIR548Nchr2

179453674

+MIR548Nchr2

179453399

-
intron-intronENST00000408742ENST00000408742MIR548Nchr2

179416978

-MIR548Nchr2

179453312

+
intron-intronENST00000408742ENST00000408742MIR548Nchr2

179417481

+MIR548Nchr2

179417547

-
intron-intronENST00000408742ENST00000408742MIR548Nchr2

179414774

-MIR548Nchr2

179414087

+
intron-intronENST00000408742ENST00000408742MIR548Nchr2

179435304

-MIR548Nchr2

179435166

+

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FusionProtFeatures for MIR548N_MIR548N


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIR548N

MIR548N

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIR548N_MIR548N


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIR548N_MIR548N


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIR548N_MIR548N


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIR548N_MIR548N


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource