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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21997

FusionGeneSummary for MIPOL1_TRIM38

check button Fusion gene summary
Fusion gene informationFusion gene name: MIPOL1_TRIM38
Fusion gene ID: 21997
HgeneTgene
Gene symbol

MIPOL1

TRIM38

Gene ID

145282

10475

Gene namemirror-image polydactyly 1tripartite motif containing 38
SynonymsCCDC193RNF15|RORET
Cytomap

14q13.3-q21.1

6p22.2

Type of geneprotein-codingprotein-coding
Descriptionmirror-image polydactyly gene 1 proteinE3 ubiquitin-protein ligase TRIM38RING-type E3 ubiquitin transferase TRIM38Ro/SSA ribonucleoprotein homologring finger protein 15tripartite motif-containing protein 38zinc finger protein RoRet
Modification date2018051920180522
UniProtAcc

Q8TD10

O00635

Ensembl transtripts involved in fusion geneENST00000536774, ENST00000327441, 
ENST00000539062, ENST00000556451, 
ENST00000396294, ENST00000545536, 
ENST00000537471, ENST00000539174, 
ENST00000357085, ENST00000349458, 
Fusion gene scores* DoF score10 X 7 X 7=4902 X 2 X 2=8
# samples 112
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MIPOL1 [Title/Abstract] AND TRIM38 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM38

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

23077300

TgeneTRIM38

GO:0046598

positive regulation of viral entry into host cell

18248090

TgeneTRIM38

GO:0051091

positive regulation of DNA binding transcription factor activity

23077300

TgeneTRIM38

GO:0051092

positive regulation of NF-kappaB transcription factor activity

23077300


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A48U-01AMIPOL1chr14

37892154

+TRIM38chr6

25972097

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000536774ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000536774ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000327441ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000327441ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000539062ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000539062ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000556451ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000556451ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000396294ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000396294ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000545536ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000545536ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000537471ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
Frame-shiftENST00000537471ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
intron-3CDSENST00000539174ENST00000357085MIPOL1chr14

37892154

+TRIM38chr6

25972097

+
intron-3CDSENST00000539174ENST00000349458MIPOL1chr14

37892154

+TRIM38chr6

25972097

+

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FusionProtFeatures for MIPOL1_TRIM38


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIPOL1

Q8TD10

TRIM38

O00635

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linkedpolyubiquitination and proteasomal degradation of the critical TLRadapter TICAM1, inhibiting TLR3-mediated type I interferonsignaling. {ECO:0000269|PubMed:23056470}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIPOL1_TRIM38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIPOL1_TRIM38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MIPOL1LATS2, ARNT2, DGCR6, ATP5O, BYSL, CKS1B, UBE2K, MAGEA6, MCM7, MFAP1, CDK18, SMARCE1, CCT3, EIF4E2, USH1C, SSX3, NEBL, PPP1R13B, PRPF31, DIEXF, MYLIP, TTC12, RBM41, RCOR3, SCNM1, CCDC33, ENKD1, FAM161A, TCHP, ZGPAT, BEX2, FBF1, EAF1, HAUS1, MIPOL1, RTP5, LRRC39, SRPK2, DUSP13, RGS2, ZNF408, CCDC172, SH3BP5L, TSPYL4TRIM38UBE2U, ELAVL1, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, TRAF6, ATXN1, TICAM1, HSPA1A, TAB2, TAB3, HSPA2, HSPA8, RFC5, SDCBP, STXBP1, UBE2I, EIF1B, TRIM38, TSPYL4, GORASP2, GMCL1, AZI2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIPOL1_TRIM38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIPOL1_TRIM38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIPOL1C0152427Polydactyly1CTD_human