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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21990

FusionGeneSummary for MIPOL1_EIF4G2

check button Fusion gene summary
Fusion gene informationFusion gene name: MIPOL1_EIF4G2
Fusion gene ID: 21990
HgeneTgene
Gene symbol

MIPOL1

EIF4G2

Gene ID

145282

1982

Gene namemirror-image polydactyly 1eukaryotic translation initiation factor 4 gamma 2
SynonymsCCDC193AAG1|DAP5|NAT1|P97
Cytomap

14q13.3-q21.1

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionmirror-image polydactyly gene 1 proteineukaryotic translation initiation factor 4 gamma 2DAP-5aging-associated protein 1death-associated protein 5eIF-4-gamma 2eIF-4G 2eIF4G 2eukaryotic translation initiation factor 4G-like 1
Modification date2018051920180523
UniProtAcc

Q8TD10

P78344

Ensembl transtripts involved in fusion geneENST00000536774, ENST00000327441, 
ENST00000539062, ENST00000556451, 
ENST00000396294, ENST00000545536, 
ENST00000537471, ENST00000539174, 
ENST00000526148, ENST00000525681, 
ENST00000339995, ENST00000396525, 
ENST00000525995, 
Fusion gene scores* DoF score10 X 7 X 7=49011 X 16 X 3=528
# samples 1118
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/528*10)=-1.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIPOL1 [Title/Abstract] AND EIF4G2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF4G2

GO:0006446

regulation of translational initiation

11943866


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ940036MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000536774ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000536774ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000536774ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000536774ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000536774ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000327441ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000327441ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000327441ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000327441ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000327441ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539062ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539062ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539062ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539062ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539062ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000556451ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000556451ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000556451ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000556451ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000556451ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000396294ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000396294ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000396294ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000396294ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000396294ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000545536ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000545536ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000545536ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000545536ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000545536ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000537471ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000537471ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000537471ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000537471ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000537471ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539174ENST00000526148MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539174ENST00000525681MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539174ENST00000339995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539174ENST00000396525MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-
intron-intronENST00000539174ENST00000525995MIPOL1chr14

37676809

+EIF4G2chr11

10820022

-

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FusionProtFeatures for MIPOL1_EIF4G2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIPOL1

Q8TD10

EIF4G2

P78344


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIPOL1_EIF4G2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIPOL1_EIF4G2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIPOL1_EIF4G2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIPOL1_EIF4G2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIPOL1C0152427Polydactyly1CTD_human