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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21989

FusionGeneSummary for MIPOL1_DGKB

check button Fusion gene summary
Fusion gene informationFusion gene name: MIPOL1_DGKB
Fusion gene ID: 21989
HgeneTgene
Gene symbol

MIPOL1

DGKB

Gene ID

145282

1607

Gene namemirror-image polydactyly 1diacylglycerol kinase beta
SynonymsCCDC193DAGK2|DGK|DGK-BETA
Cytomap

14q13.3-q21.1

7p21.2

Type of geneprotein-codingprotein-coding
Descriptionmirror-image polydactyly gene 1 proteindiacylglycerol kinase beta90 kDa diacylglycerol kinaseDAG kinase betadiacylglycerol kinase, beta 90kDadiglyceride kinase beta
Modification date2018051920180519
UniProtAcc

Q8TD10

Q9Y6T7

Ensembl transtripts involved in fusion geneENST00000536774, ENST00000327441, 
ENST00000539062, ENST00000556451, 
ENST00000396294, ENST00000545536, 
ENST00000537471, ENST00000539174, 
ENST00000399322, ENST00000258767, 
ENST00000403951, ENST00000402815, 
ENST00000407950, ENST00000444700, 
ENST00000406247, ENST00000403963, 
Fusion gene scores* DoF score10 X 7 X 7=4909 X 7 X 7=441
# samples 119
** MAII scorelog2(11/490*10)=-2.15527822547791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIPOL1 [Title/Abstract] AND DGKB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDGKB

GO:0046486

glycerolipid metabolic process

22627129

TgeneDGKB

GO:0046834

lipid phosphorylation

22627129


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1FJ423747MIPOL1chr14

37969343

+DGKBchr7

14188863

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000536774ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000536774ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000536774ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000536774ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000536774ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000536774ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000536774ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000536774ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000327441ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000327441ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000327441ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000327441ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000327441ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000327441ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000327441ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000327441ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000539062ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000539062ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000539062ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000539062ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000539062ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000539062ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000539062ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000539062ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000556451ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000556451ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000556451ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000556451ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000556451ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000556451ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000556451ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000556451ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000396294ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000396294ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000396294ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000396294ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000396294ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000396294ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000396294ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000396294ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000545536ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000545536ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000545536ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000545536ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000545536ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000545536ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000545536ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000545536ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000537471ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000537471ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000537471ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000537471ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
In-frameENST00000537471ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
Frame-shiftENST00000537471ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000537471ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
5CDS-intronENST00000537471ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-3CDSENST00000539174ENST00000399322MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-3CDSENST00000539174ENST00000258767MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-3CDSENST00000539174ENST00000403951MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-3CDSENST00000539174ENST00000402815MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-3CDSENST00000539174ENST00000407950MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-3CDSENST00000539174ENST00000444700MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-intronENST00000539174ENST00000406247MIPOL1chr14

37969343

+DGKBchr7

14188863

-
intron-intronENST00000539174ENST00000403963MIPOL1chr14

37969343

+DGKBchr7

14188863

-

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FusionProtFeatures for MIPOL1_DGKB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIPOL1

Q8TD10

DGKB

Q9Y6T7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000327441+1314107_212420443Coiled coilOntology_term=ECO:0000255
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000396294+1415107_212420443Coiled coilOntology_term=ECO:0000255
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000536774+78107_212239262Coiled coilOntology_term=ECO:0000255
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000537471+1213107_212420443Coiled coilOntology_term=ECO:0000255
TgeneDGKBchr14:37969343chr7:14188863ENST00000406247-024162_173-28774Calcium binding1
TgeneDGKBchr14:37969343chr7:14188863ENST00000406247-024207_218-28774Calcium binding2
TgeneDGKBchr14:37969343chr7:14188863ENST00000406247-024149_184-28774DomainEF-hand 1
TgeneDGKBchr14:37969343chr7:14188863ENST00000406247-024194_229-28774DomainEF-hand 2
TgeneDGKBchr14:37969343chr7:14188863ENST00000406247-024434_568-28774DomainDAGKc
TgeneDGKBchr14:37969343chr7:14188863ENST00000406247-024244_294-28774Zinc fingerPhorbol-ester/DAG-type 1
TgeneDGKBchr14:37969343chr7:14188863ENST00000406247-024309_358-28774Zinc fingerPhorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000327441+1314253_435420443Coiled coilOntology_term=ECO:0000255
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000396294+1415253_435420443Coiled coilOntology_term=ECO:0000255
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000536774+78253_435239262Coiled coilOntology_term=ECO:0000255
HgeneMIPOL1chr14:37969343chr7:14188863ENST00000537471+1213253_435420443Coiled coilOntology_term=ECO:0000255
TgeneDGKBchr14:37969343chr7:14188863ENST00000399322-2325162_173769805Calcium binding1
TgeneDGKBchr14:37969343chr7:14188863ENST00000399322-2325207_218769805Calcium binding2
TgeneDGKBchr14:37969343chr7:14188863ENST00000403951-2426162_173769805Calcium binding1
TgeneDGKBchr14:37969343chr7:14188863ENST00000403951-2426207_218769805Calcium binding2
TgeneDGKBchr14:37969343chr7:14188863ENST00000399322-2325149_184769805DomainEF-hand 1
TgeneDGKBchr14:37969343chr7:14188863ENST00000399322-2325194_229769805DomainEF-hand 2
TgeneDGKBchr14:37969343chr7:14188863ENST00000399322-2325434_568769805DomainDAGKc
TgeneDGKBchr14:37969343chr7:14188863ENST00000403951-2426149_184769805DomainEF-hand 1
TgeneDGKBchr14:37969343chr7:14188863ENST00000403951-2426194_229769805DomainEF-hand 2
TgeneDGKBchr14:37969343chr7:14188863ENST00000403951-2426434_568769805DomainDAGKc
TgeneDGKBchr14:37969343chr7:14188863ENST00000399322-2325244_294769805Zinc fingerPhorbol-ester/DAG-type 1
TgeneDGKBchr14:37969343chr7:14188863ENST00000399322-2325309_358769805Zinc fingerPhorbol-ester/DAG-type 2
TgeneDGKBchr14:37969343chr7:14188863ENST00000403951-2426244_294769805Zinc fingerPhorbol-ester/DAG-type 1
TgeneDGKBchr14:37969343chr7:14188863ENST00000403951-2426309_358769805Zinc fingerPhorbol-ester/DAG-type 2


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FusionGeneSequence for MIPOL1_DGKB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIPOL1_DGKB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MIPOL1LATS2, ARNT2, DGCR6, ATP5O, BYSL, CKS1B, UBE2K, MAGEA6, MCM7, MFAP1, CDK18, SMARCE1, CCT3, EIF4E2, USH1C, SSX3, NEBL, PPP1R13B, PRPF31, DIEXF, MYLIP, TTC12, RBM41, RCOR3, SCNM1, CCDC33, ENKD1, FAM161A, TCHP, ZGPAT, BEX2, FBF1, EAF1, HAUS1, MIPOL1, RTP5, LRRC39, SRPK2, DUSP13, RGS2, ZNF408, CCDC172, SH3BP5L, TSPYL4DGKBKRT31, PCDHB5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIPOL1_DGKB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIPOL1_DGKB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMIPOL1C0152427Polydactyly1CTD_human
TgeneDGKBC0005586Bipolar Disorder1PSYGENET
TgeneDGKBC0011570Mental Depression1PSYGENET
TgeneDGKBC0011581Depressive disorder1PSYGENET