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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21977

FusionGeneSummary for MINOS1_PTMA

check button Fusion gene summary
Fusion gene informationFusion gene name: MINOS1_PTMA
Fusion gene ID: 21977
HgeneTgene
Gene symbol

MINOS1

PTMA

Gene ID

440574

5757

Gene namemitochondrial inner membrane organizing system 1prothymosin alpha
SynonymsC1orf151|MIO10|Mic10TMSA
Cytomap

1p36.13

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionMICOS complex subunit MIC10RP5-1056L3.2UPF0327 protein C1orf151mitochondrial inner membrane organizing system protein 1prothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-
Modification date2018052320180522
UniProtAcc

Q5TGZ0

P06454

Ensembl transtripts involved in fusion geneENST00000486890, ENST00000322753, 
ENST00000466801, ENST00000409321, 
ENST00000409115, ENST00000341369, 
ENST00000409683, ENST00000410064, 
Fusion gene scores* DoF score5 X 3 X 3=4517 X 17 X 2=578
# samples 518
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(18/578*10)=-1.683072586171
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MINOS1 [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG481927MINOS1chr1

19934638

+PTMAchr2

232576675

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000486890ENST00000466801MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000486890ENST00000409321MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000486890ENST00000409115MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000486890ENST00000341369MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000486890ENST00000409683MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000486890ENST00000410064MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000322753ENST00000466801MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000322753ENST00000409321MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000322753ENST00000409115MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000322753ENST00000341369MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000322753ENST00000409683MINOS1chr1

19934638

+PTMAchr2

232576675

+
intron-3UTRENST00000322753ENST00000410064MINOS1chr1

19934638

+PTMAchr2

232576675

+

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FusionProtFeatures for MINOS1_PTMA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MINOS1

Q5TGZ0

PTMA

P06454

Component of the MICOS complex, a large protein complexof the mitochondrial inner membrane that plays crucial roles inthe maintenance of crista junctions, inner membrane architecture,and formation of contact sites to the outer membrane.{ECO:0000269|PubMed:22114354}. Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MINOS1_PTMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MINOS1_PTMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MINOS1_PTMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MINOS1_PTMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTMAC0001430Adenoma1CTD_human
TgenePTMAC0015695Fatty Liver1CTD_human
TgenePTMAC0024121Lung Neoplasms1CTD_human
TgenePTMAC0035412Rhabdomyosarcoma1CTD_human