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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21976

FusionGeneSummary for MINOS1_PQLC2

check button Fusion gene summary
Fusion gene informationFusion gene name: MINOS1_PQLC2
Fusion gene ID: 21976
HgeneTgene
Gene symbol

MINOS1

PQLC2

Gene ID

440574

54896

Gene namemitochondrial inner membrane organizing system 1PQ loop repeat containing 2
SynonymsC1orf151|MIO10|Mic10-
Cytomap

1p36.13

1p36.13

Type of geneprotein-codingprotein-coding
DescriptionMICOS complex subunit MIC10RP5-1056L3.2UPF0327 protein C1orf151mitochondrial inner membrane organizing system protein 1lysosomal amino acid transporter 1 homologPQ-loop repeat-containing protein 2
Modification date2018052320180523
UniProtAcc

Q5TGZ0

Q6ZP29

Ensembl transtripts involved in fusion geneENST00000486890, ENST00000322753, 
ENST00000375155, ENST00000375153, 
ENST00000400548, 
Fusion gene scores* DoF score5 X 3 X 3=453 X 3 X 3=27
# samples 53
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MINOS1 [Title/Abstract] AND PQLC2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePQLC2

GO:0015809

arginine transport

22822152

TgenePQLC2

GO:0015819

lysine transport

22822152

TgenePQLC2

GO:0080144

amino acid homeostasis

22822152


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-ER-A19G-06AMINOS1chr1

19923603

+PQLC2chr1

19651127

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486890ENST00000375155MINOS1chr1

19923603

+PQLC2chr1

19651127

+
3UTR-3CDSENST00000486890ENST00000375153MINOS1chr1

19923603

+PQLC2chr1

19651127

+
3UTR-5UTRENST00000486890ENST00000400548MINOS1chr1

19923603

+PQLC2chr1

19651127

+
Frame-shiftENST00000322753ENST00000375155MINOS1chr1

19923603

+PQLC2chr1

19651127

+
Frame-shiftENST00000322753ENST00000375153MINOS1chr1

19923603

+PQLC2chr1

19651127

+
5CDS-5UTRENST00000322753ENST00000400548MINOS1chr1

19923603

+PQLC2chr1

19651127

+

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FusionProtFeatures for MINOS1_PQLC2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MINOS1

Q5TGZ0

PQLC2

Q6ZP29

Component of the MICOS complex, a large protein complexof the mitochondrial inner membrane that plays crucial roles inthe maintenance of crista junctions, inner membrane architecture,and formation of contact sites to the outer membrane.{ECO:0000269|PubMed:22114354}. Amino acid transporter that specifically mediates thepH-dependent export of the cationic amino acids arginine,histidine and lysine from lysosomes. {ECO:0000269|PubMed:22822152,ECO:0000269|PubMed:23169667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MINOS1_PQLC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MINOS1_PQLC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MINOS1IMMT, CHCHD3, HSPA9, MTX2, RMDN1, SAMM50, IBA57, ACOT9, GDI1, DNAJC11, MAPK1, TUBGCP2, MTX1, MTHFD2, FECH, TUBG1, COA7, ACSL4, C1QBP, GSTK1, MIA3, RDH13, MOV10, NXF1, EGFR, UNK, TRIM25PQLC2NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MINOS1_PQLC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MINOS1_PQLC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource