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Fusion gene ID: 21963 |
FusionGeneSummary for MINK1_DAZAP2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MINK1_DAZAP2 | Fusion gene ID: 21963 | Hgene | Tgene | Gene symbol | MINK1 | DAZAP2 | Gene ID | 50488 | 9802 |
Gene name | misshapen like kinase 1 | DAZ associated protein 2 | |
Synonyms | B55|MAP4K6|MINK|YSK2|ZC3 | PRTB | |
Cytomap | 17p13.2 | 12q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | misshapen-like kinase 1GCK family kinase MINKMAPK/ERK kinase kinase kinase 6MEK kinase kinase 6MEKKK 6misshapen/NIK-related kinasemitogen-activated protein kinase kinase kinase kinase 6 | DAZ-associated protein 2deleted in azoospermia associated protein 2proline-rich transcript in brainproline-rich transcript, brain-expressed protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q8N4C8 | Q15038 | |
Ensembl transtripts involved in fusion gene | ENST00000355280, ENST00000347992, ENST00000453408, | ENST00000604900, ENST00000412716, ENST00000449723, ENST00000549555, ENST00000439799, ENST00000425012, ENST00000549732, ENST00000551534, ENST00000551313, | |
Fusion gene scores | * DoF score | 8 X 4 X 5=160 | 6 X 7 X 3=126 |
# samples | 9 | 8 | |
** MAII score | log2(9/160*10)=-0.830074998557688 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MINK1 [Title/Abstract] AND DAZAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MINK1 | GO:0046777 | protein autophosphorylation | 15469942 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA325636 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + | ||
ChiTaRS3.1 | AW964905 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000355280 | ENST00000604900 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000355280 | ENST00000412716 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000355280 | ENST00000449723 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000355280 | ENST00000549555 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000355280 | ENST00000439799 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000355280 | ENST00000425012 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000355280 | ENST00000549732 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-intron | ENST00000355280 | ENST00000551534 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-intron | ENST00000355280 | ENST00000551313 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000347992 | ENST00000604900 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000347992 | ENST00000412716 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000347992 | ENST00000449723 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000347992 | ENST00000549555 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000347992 | ENST00000439799 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000347992 | ENST00000425012 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-5UTR | ENST00000347992 | ENST00000549732 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-intron | ENST00000347992 | ENST00000551534 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
3UTR-intron | ENST00000347992 | ENST00000551313 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-5UTR | ENST00000453408 | ENST00000604900 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-5UTR | ENST00000453408 | ENST00000412716 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-5UTR | ENST00000453408 | ENST00000449723 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-5UTR | ENST00000453408 | ENST00000549555 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-5UTR | ENST00000453408 | ENST00000439799 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-5UTR | ENST00000453408 | ENST00000425012 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-5UTR | ENST00000453408 | ENST00000549732 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-intron | ENST00000453408 | ENST00000551534 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
intron-intron | ENST00000453408 | ENST00000551313 | MINK1 | chr17 | 4801127 | + | DAZAP2 | chr12 | 51632677 | + |
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FusionProtFeatures for MINK1_DAZAP2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MINK1 | DAZAP2 |
Serine/threonine kinase which acts as a negativeregulator of Ras-related Rap2-mediated signal transduction tocontrol neuronal structure and AMPA receptor trafficking. Requiredfor normal synaptic density, dendrite complexity, as well assurface AMPA receptor expression in hippocampal neurons. Canactivate the JNK and MAPK14/p38 pathways and mediates stimulationof the stress-activated protein kinase MAPK14/p38 MAPK downstreamof the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation byRAP2A, MBP and SMAD1. Has an essential function in negativeselection of thymocytes, perhaps by coupling NCK1 to activation ofJNK1. Isoform 4 can activate the JNK pathway. Involved in theregulation of actin cytoskeleton reorganization, cell-matrixadhesion, cell-cell adhesion and cell migration. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MINK1_DAZAP2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MINK1_DAZAP2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MINK1_DAZAP2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MINK1_DAZAP2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |