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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21963

FusionGeneSummary for MINK1_DAZAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MINK1_DAZAP2
Fusion gene ID: 21963
HgeneTgene
Gene symbol

MINK1

DAZAP2

Gene ID

50488

9802

Gene namemisshapen like kinase 1DAZ associated protein 2
SynonymsB55|MAP4K6|MINK|YSK2|ZC3PRTB
Cytomap

17p13.2

12q13.13

Type of geneprotein-codingprotein-coding
Descriptionmisshapen-like kinase 1GCK family kinase MINKMAPK/ERK kinase kinase kinase 6MEK kinase kinase 6MEKKK 6misshapen/NIK-related kinasemitogen-activated protein kinase kinase kinase kinase 6DAZ-associated protein 2deleted in azoospermia associated protein 2proline-rich transcript in brainproline-rich transcript, brain-expressed protein
Modification date2018052320180522
UniProtAcc

Q8N4C8

Q15038

Ensembl transtripts involved in fusion geneENST00000355280, ENST00000347992, 
ENST00000453408, 
ENST00000604900, 
ENST00000412716, ENST00000449723, 
ENST00000549555, ENST00000439799, 
ENST00000425012, ENST00000549732, 
ENST00000551534, ENST00000551313, 
Fusion gene scores* DoF score8 X 4 X 5=1606 X 7 X 3=126
# samples 98
** MAII scorelog2(9/160*10)=-0.830074998557688
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MINK1 [Title/Abstract] AND DAZAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMINK1

GO:0046777

protein autophosphorylation

15469942


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA325636MINK1chr17

4801127

+DAZAP2chr12

51632677

+
ChiTaRS3.1AW964905MINK1chr17

4801127

+DAZAP2chr12

51632677

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000355280ENST00000604900MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000355280ENST00000412716MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000355280ENST00000449723MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000355280ENST00000549555MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000355280ENST00000439799MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000355280ENST00000425012MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000355280ENST00000549732MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-intronENST00000355280ENST00000551534MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-intronENST00000355280ENST00000551313MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000347992ENST00000604900MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000347992ENST00000412716MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000347992ENST00000449723MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000347992ENST00000549555MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000347992ENST00000439799MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000347992ENST00000425012MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-5UTRENST00000347992ENST00000549732MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-intronENST00000347992ENST00000551534MINK1chr17

4801127

+DAZAP2chr12

51632677

+
3UTR-intronENST00000347992ENST00000551313MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-5UTRENST00000453408ENST00000604900MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-5UTRENST00000453408ENST00000412716MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-5UTRENST00000453408ENST00000449723MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-5UTRENST00000453408ENST00000549555MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-5UTRENST00000453408ENST00000439799MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-5UTRENST00000453408ENST00000425012MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-5UTRENST00000453408ENST00000549732MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-intronENST00000453408ENST00000551534MINK1chr17

4801127

+DAZAP2chr12

51632677

+
intron-intronENST00000453408ENST00000551313MINK1chr17

4801127

+DAZAP2chr12

51632677

+

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FusionProtFeatures for MINK1_DAZAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MINK1

Q8N4C8

DAZAP2

Q15038

Serine/threonine kinase which acts as a negativeregulator of Ras-related Rap2-mediated signal transduction tocontrol neuronal structure and AMPA receptor trafficking. Requiredfor normal synaptic density, dendrite complexity, as well assurface AMPA receptor expression in hippocampal neurons. Canactivate the JNK and MAPK14/p38 pathways and mediates stimulationof the stress-activated protein kinase MAPK14/p38 MAPK downstreamof the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation byRAP2A, MBP and SMAD1. Has an essential function in negativeselection of thymocytes, perhaps by coupling NCK1 to activation ofJNK1. Isoform 4 can activate the JNK pathway. Involved in theregulation of actin cytoskeleton reorganization, cell-matrixadhesion, cell-cell adhesion and cell migration.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MINK1_DAZAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MINK1_DAZAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MINK1_DAZAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MINK1_DAZAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource