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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21956

FusionGeneSummary for MIER3_ABCC12

check button Fusion gene summary
Fusion gene informationFusion gene name: MIER3_ABCC12
Fusion gene ID: 21956
HgeneTgene
Gene symbol

MIER3

ABCC12

Gene ID

166968

94160

Gene nameMIER family member 3ATP binding cassette subfamily C member 12
Synonyms-MRP9
Cytomap

5q11.2

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionmesoderm induction early response protein 3mesoderm induction early response 1, family member 3mi-er3multidrug resistance-associated protein 9ATP-binding cassette sub-family C member 12ATP-binding cassette transporter sub-family C member 12ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Modification date2018052320180523
UniProtAcc

Q7Z3K6

Q96J65

Ensembl transtripts involved in fusion geneENST00000381226, ENST00000381213, 
ENST00000381199, ENST00000409421, 
ENST00000546593, 		ENST00000311303, 
ENST00000448542, ENST00000416054, 
ENST00000532355, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: MIER3 [Title/Abstract] AND ABCC12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIER3

GO:0016575

histone deacetylation

28046085


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-ZG-A9LZ-01AMIER3chr5

56229074

-ABCC12chr16

48130843

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000381226ENST00000311303MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381226ENST00000448542MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-3UTRENST00000381226ENST00000416054MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381226ENST00000532355MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381213ENST00000311303MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381213ENST00000448542MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-3UTRENST00000381213ENST00000416054MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381213ENST00000532355MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381199ENST00000311303MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381199ENST00000448542MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-3UTRENST00000381199ENST00000416054MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000381199ENST00000532355MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000409421ENST00000311303MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000409421ENST00000448542MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-3UTRENST00000409421ENST00000416054MIER3chr5

56229074

-ABCC12chr16

48130843

-
5CDS-intronENST00000409421ENST00000532355MIER3chr5

56229074

-ABCC12chr16

48130843

-
intron-intronENST00000546593ENST00000311303MIER3chr5

56229074

-ABCC12chr16

48130843

-
intron-intronENST00000546593ENST00000448542MIER3chr5

56229074

-ABCC12chr16

48130843

-
intron-3UTRENST00000546593ENST00000416054MIER3chr5

56229074

-ABCC12chr16

48130843

-
intron-intronENST00000546593ENST00000532355MIER3chr5

56229074

-ABCC12chr16

48130843

-

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FusionProtFeatures for MIER3_ABCC12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIER3

Q7Z3K6

ABCC12

Q96J65

Transcriptional repressor. {ECO:0000250}. Probable transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIER3_ABCC12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIER3_ABCC12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MIER3HDAC2, HDAC1, HIST1H2BA, WIZ, C16orf87, H2AFXABCC12VCPIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIER3_ABCC12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIER3_ABCC12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCC12C0005956Bone Marrow Diseases1CTD_human
TgeneABCC12C0041755Adverse reaction to drug1CTD_human