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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21941

FusionGeneSummary for MIEF1_TAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MIEF1_TAB1
Fusion gene ID: 21941
HgeneTgene
Gene symbol

MIEF1

TAB1

Gene ID

54471

10454

Gene namemitochondrial elongation factor 1TGF-beta activated kinase 1 (MAP3K7) binding protein 1
SynonymsHSU79252|MID51|SMCR7L|dJ1104E15.33'-Tab1|MAP3K7IP1
Cytomap

22q13.1

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial dynamics protein MID51SMCR7-like proteinSmith-Magenis syndrome chromosome region, candidate 7-likemitochondrial dynamic protein MID51mitochondrial dynamic protein of 51 kDamitochondrial dynamics protein of 51 kDasmith-Magenis syndrome TGF-beta-activated kinase 1 and MAP3K7-binding protein 1TAK1-binding protein 1mitogen-activated protein kinase kinase kinase 7-interacting protein 1transforming growth factor beta-activated kinase-binding protein 1
Modification date2018051920180522
UniProtAcc

Q9NQG6

Q15750

Ensembl transtripts involved in fusion geneENST00000402881, ENST00000478342, 
ENST00000325301, ENST00000404569, 
ENST00000216160, ENST00000331454, 
ENST00000488859, 
Fusion gene scores* DoF score2 X 2 X 3=124 X 3 X 4=48
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MIEF1 [Title/Abstract] AND TAB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIEF1

GO:0090141

positive regulation of mitochondrial fission

23283981|23530241

HgeneMIEF1

GO:0090314

positive regulation of protein targeting to membrane

23283981

HgeneMIEF1

GO:0090314

positive regulation of protein targeting to membrane

23921378


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-31-1946-01AMIEF1chr22

39900539

+TAB1chr22

39832495

+
TCGALDSTADTCGA-VQ-A92D-01AMIEF1chr22

39900539

+TAB1chr22

39822708

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000402881ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-intronENST00000402881ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-3UTRENST00000402881ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39832495

+
5CDS-intronENST00000478342ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39832495

+
5CDS-intronENST00000478342ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39832495

+
5CDS-3UTRENST00000478342ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-intronENST00000325301ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-intronENST00000325301ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-3UTRENST00000325301ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-intronENST00000404569ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-intronENST00000404569ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-3UTRENST00000404569ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39832495

+
5UTR-3CDSENST00000402881ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-3CDSENST00000402881ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-intronENST00000402881ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39822708

+
Frame-shiftENST00000478342ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39822708

+
Frame-shiftENST00000478342ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39822708

+
5CDS-intronENST00000478342ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-3CDSENST00000325301ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-3CDSENST00000325301ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-intronENST00000325301ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-3CDSENST00000404569ENST00000216160MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-3CDSENST00000404569ENST00000331454MIEF1chr22

39900539

+TAB1chr22

39822708

+
5UTR-intronENST00000404569ENST00000488859MIEF1chr22

39900539

+TAB1chr22

39822708

+

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FusionProtFeatures for MIEF1_TAB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIEF1

Q9NQG6

TAB1

Q15750

Mitochondrial outer membrane protein which regulatesmitochondrial fission. Promotes the recruitment and association ofthe fission mediator dynamin-related protein 1 (DNM1L) to themitochondrial surface independently of the mitochondrial fissionFIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1Loligomerization. Binds ADP and can also bind GDP, although withlower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. InhibitsDNM1L GTPase activity in the absence of bound ADP. Requires ADP tostimulate DNM1L GTPase activity and the assembly of DNM1L intolong, oligomeric tubules with a spiral pattern, as opposed to thering-like DNM1L oligomers observed in the absence of bound ADP.Does not require ADP for its function in recruiting DNM1L.{ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:21701560,ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241,ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:24515348}. May be an important signaling intermediate between TGFBreceptors and MAP3K7/TAK1. May play an important role in mammalianembryogenesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIEF1_TAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIEF1_TAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MIEF1MAGEA1, YWHAG, MIEF1, DNM1L, FIS1, UBQLN1, AGTRAP, MAB21L2, WDFY2, CDC42, ZNFX1, MAOATAB1TAB2, TRAF2, MAP3K7, TAB3, SMAD7, XIAP, SMAD6, MAPK14, ZMYND11, TRAF6, TNF, AGO3, RIPK2, MORF4L1, MORF4L2, MTG2, PHACTR3, C9orf78, CARD11, PDCD6IP, CASP6, PPP1R7, GIT1, XPO7, NXPH3, URB1, PHC2, POLR3D, RPL10, ACAP3, SERPINA4, CKB, CFL1, DBN1, MICAL1, KIFC2, MON1A, LAP3, ASRGL1, RBX1, MAPKAPK5, POLDIP2, FADD, LCMT1, PTPMT1, EPRS, C2orf44, HNRNPR, ARAP1, RPLP1, SNRNP35, TSSC4, TRPC4AP, PRKAR1A, ARRB2, NR2C2, OGT, GRK5, EGFR, IKBKB, NOTCH1, BST2, HSP90AA1, MAPK12, MAPK8IP1, GRB2, BIRC3, NPM1, TRIP6, CDK5RAP3, WTAP, PPP2CB, PPP2R1A, FN1, CORO1A, SLMAP, MDM2, TIRAP, BAG2, MAGED1, NAIP, BIRC7, SHMT2, MOV10, NXF1, IKBKG, MAP3K1, C11orf70, MAMDC2, RFPL4B, CARD8, PRMT2, C9orf41, TMEM52B, SSX2IP, CNTROB, XPO1, HSPA1L, MAPK11, ITCH, ALKBH3, MCM2, USP18, F2R, SMURF1, MTMR8, EMILIN1, SYNC, AARSD1, SERPINB2, SCRN1, CCDC102B, MANSC1, PCDH20, TBL1Y, HSPA8, CYB5A, GANAB, HSPBP1, TH, PCDHGB4, PSMC3, KLHL10, CCL22, C6orf141, CRYBB3, UBC, AATK, ERBB4, ROR2, CYLD, PARK7, SOD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIEF1_TAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIEF1_TAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTAB1C0032460Polycystic Ovary Syndrome1CTD_human