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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21938

FusionGeneSummary for MIDN_MIDN

check button Fusion gene summary
Fusion gene informationFusion gene name: MIDN_MIDN
Fusion gene ID: 21938
HgeneTgene
Gene symbol

MIDN

MIDN

Gene ID

90007

90007

Gene namemidnolinmidnolin
Synonyms--
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionmidnolinmidbrain nucleolar proteinmidnolinmidbrain nucleolar protein
Modification date2018051920180519
UniProtAcc

Q504T8

Q504T8

Ensembl transtripts involved in fusion geneENST00000300952, ENST00000591446, 
ENST00000300952, ENST00000591446, 
Fusion gene scores* DoF score8 X 6 X 5=2404 X 5 X 3=60
# samples 117
** MAII scorelog2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MIDN [Title/Abstract] AND MIDN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA641890MIDNchr19

1258639

+MIDNchr19

1258104

+
ChiTaRS3.1AA883525MIDNchr19

1258639

+MIDNchr19

1258098

+
ChiTaRS3.1AA972435MIDNchr19

1258639

+MIDNchr19

1258104

+
ChiTaRS3.1AW303967MIDNchr19

1258639

+MIDNchr19

1258104

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000300952ENST00000300952MIDNchr19

1258639

+MIDNchr19

1258104

+
3UTR-3UTRENST00000300952ENST00000591446MIDNchr19

1258639

+MIDNchr19

1258104

+
3UTR-3UTRENST00000591446ENST00000300952MIDNchr19

1258639

+MIDNchr19

1258104

+
3UTR-3UTRENST00000591446ENST00000591446MIDNchr19

1258639

+MIDNchr19

1258104

+
3UTR-3UTRENST00000300952ENST00000300952MIDNchr19

1258639

+MIDNchr19

1258098

+
3UTR-3UTRENST00000300952ENST00000591446MIDNchr19

1258639

+MIDNchr19

1258098

+
3UTR-3UTRENST00000591446ENST00000300952MIDNchr19

1258639

+MIDNchr19

1258098

+
3UTR-3UTRENST00000591446ENST00000591446MIDNchr19

1258639

+MIDNchr19

1258098

+

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FusionProtFeatures for MIDN_MIDN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIDN

Q504T8

MIDN

Q504T8

Facilitates ubiquitin-independent proteasomaldegradation of polycomb protein CBX4. Plays a role in inhibitingthe activity of glucokinase GCK and both glucose-induced and basalinsulin secretion. {ECO:0000250|UniProtKB:D4AE48,ECO:0000250|UniProtKB:Q3TPJ7}. Facilitates ubiquitin-independent proteasomaldegradation of polycomb protein CBX4. Plays a role in inhibitingthe activity of glucokinase GCK and both glucose-induced and basalinsulin secretion. {ECO:0000250|UniProtKB:D4AE48,ECO:0000250|UniProtKB:Q3TPJ7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIDN_MIDN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIDN_MIDN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIDN_MIDN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIDN_MIDN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource