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Fusion gene ID: 21933 |
FusionGeneSummary for MIDN_ARID3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MIDN_ARID3A | Fusion gene ID: 21933 | Hgene | Tgene | Gene symbol | MIDN | ARID3A | Gene ID | 90007 | 1820 |
| Gene name | midnolin | AT-rich interaction domain 3A | |
| Synonyms | - | BRIGHT|DRIL1|DRIL3|E2FBP1 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | midnolinmidbrain nucleolar protein | AT-rich interactive domain-containing protein 3AARID domain-containing 3AARID domain-containing protein 3AAT rich interactive domain 3A (BRIGHT- like) proteinAT rich interactive domain 3A (BRIGHT-like)B-cell regulator of IgH transcriptionE2F-binding | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q504T8 | Q99856 | |
| Ensembl transtripts involved in fusion gene | ENST00000300952, ENST00000591446, | ENST00000263620, ENST00000592216, | |
| Fusion gene scores | * DoF score | 8 X 6 X 5=240 | 3 X 3 X 2=18 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MIDN [Title/Abstract] AND ARID3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-44-2668-01A | MIDN | chr19 | 1250528 | + | ARID3A | chr19 | 971878 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000300952 | ENST00000263620 | MIDN | chr19 | 1250528 | + | ARID3A | chr19 | 971878 | + |
| 5CDS-intron | ENST00000300952 | ENST00000592216 | MIDN | chr19 | 1250528 | + | ARID3A | chr19 | 971878 | + |
| In-frame | ENST00000591446 | ENST00000263620 | MIDN | chr19 | 1250528 | + | ARID3A | chr19 | 971878 | + |
| 5CDS-intron | ENST00000591446 | ENST00000592216 | MIDN | chr19 | 1250528 | + | ARID3A | chr19 | 971878 | + |
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FusionProtFeatures for MIDN_ARID3A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MIDN | ARID3A |
| Facilitates ubiquitin-independent proteasomaldegradation of polycomb protein CBX4. Plays a role in inhibitingthe activity of glucokinase GCK and both glucose-induced and basalinsulin secretion. {ECO:0000250|UniProtKB:D4AE48,ECO:0000250|UniProtKB:Q3TPJ7}. | Transcription factor which may be involved in thecontrol of cell cycle progression by the RB1/E2F1 pathway and inB-cell differentiation. {ECO:0000269|PubMed:11812999,ECO:0000269|PubMed:12692263}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 550_579 | 531 | 594 | Compositional bias | Note=Gly-rich |
| Tgene | >ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 537_557 | 531 | 594 | Region | Important for cytoplasmic localization |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MIDN | chr19:1250528 | chr19:971878 | ENST00000300952 | + | 2 | 8 | 31_105 | 77 | 469 | Domain | Ubiquitin-like |
| Hgene | >MIDN | chr19:1250528 | chr19:971878 | ENST00000591446 | + | 1 | 7 | 31_105 | 77 | 469 | Domain | Ubiquitin-like |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 424_445 | 531 | 594 | Compositional bias | Note=Ala-rich |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 67_70 | 531 | 594 | Compositional bias | Note=Poly-Ala |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 89_157 | 531 | 594 | Compositional bias | Note=Glu-rich |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 238_330 | 531 | 594 | Domain | ARID |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 444_541 | 531 | 594 | Domain | REKLES |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 119_156 | 531 | 594 | Region | Note=Acidic |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 445_488 | 531 | 594 | Region | Important for nuclear localization |
| Tgene | ARID3A | chr19:1250528 | chr19:971878 | ENST00000263620 | + | 7 | 9 | 490_513 | 531 | 594 | Region | Note=Homodimerization |
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FusionGeneSequence for MIDN_ARID3A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MIDN_ENST00000300952_chr19_1250528_+_ARID3A_ENST00000263620_chr19_971878_+_140aa MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTSSVCSAAGPHAN >In-frame_MIDN_ENST00000591446_chr19_1250528_+_ARID3A_ENST00000263620_chr19_971878_+_140aa MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTSSVCSAAGPHAN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MIDN_ENST00000300952_chr19_1250528_+_ARID3A_ENST00000263620_chr19_971878_+_421nt ATGGAGCCGCAGCCCGGCGGCGCCCGGAGCTGCCGGCGCGGGGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCC ATGAGCCTCGCCATCCACAGCACCACGGGCACCCGCTACGACCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTG TCCCAGCGCCTCAAAGTGCCCAAGGAGCGCCTGGCTCTTCTCCACAAAGACACGAGTTCTGTTTGCTCAGCCGCCGGCCCCCACGCCAAC CTCTGCTCCCAACAAAGGAGGCGGCGGCGGCGGCGGCAGCAGCAGCAACGCAGGCGGCCGGGGAGGAAACACCGGAACCAGCGGCGGCCA >In-frame_MIDN_ENST00000591446_chr19_1250528_+_ARID3A_ENST00000263620_chr19_971878_+_421nt ATGGAGCCGCAGCCCGGCGGCGCCCGGAGCTGCCGGCGCGGGGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCC ATGAGCCTCGCCATCCACAGCACCACGGGCACCCGCTACGACCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTG TCCCAGCGCCTCAAAGTGCCCAAGGAGCGCCTGGCTCTTCTCCACAAAGACACGAGTTCTGTTTGCTCAGCCGCCGGCCCCCACGCCAAC CTCTGCTCCCAACAAAGGAGGCGGCGGCGGCGGCGGCAGCAGCAGCAACGCAGGCGGCCGGGGAGGAAACACCGGAACCAGCGGCGGCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MIDN_ENST00000300952_chr19_1250528_+_ARID3A_ENST00000263620_chr19_971878_+_4810nt GATAAAGGCTGAGGGCCGCGCGCTTGGCCCAGACCGGCCCGGCCAGCGCGCATTCGGCCCCGGACGAAGGTACTCGCAGCACTTGGAGCG CAGAACCGGCCGCGCCCGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGAC GGCACCCAGCGCCACCAGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAG AAGCAAGTGCCGTCCCCACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCAT TCCGCGGCCGGGACTTTCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCC TGTCCCGGAGGCGCGGCGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCC GGAGCTGCCGGCGCGGGGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCA CGGGCACCCGCTACGACCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGG AGCGCCTGGCTCTTCTCCACAAAGACACGAGTTCTGTTTGCTCAGCCGCCGGCCCCCACGCCAACCTCTGCTCCCAACAAAGGAGGCGGC GGCGGCGGCGGCAGCAGCAGCAACGCAGGCGGCCGGGGAGGAAACACCGGAACCAGCGGCGGCCAGGCTGGGCCAGCGGGGCTGTCCACA CCCTCCACATCTACCTCAAATAACTCGTTGCCTTAACCGCATCACTCCCCACCCGCCACCCACCCTGGAGCCCGCCGGCCTGGGCAGGGG GTCCAGGTGGGCCACACAGGGGCCAGGATGGCGGAAGATACGGGTGGGGAGGGAAGATATCCAGAAAGGAGCCACAGCTGACGCCAAAAA GAAAAGAAAAAAGATATATATATATATATATATATATACACGTATATATATAAAGAGAATTTAATAAAACAGGGGAAAACCAAGGAACAC TTGAATTTCTCAGGTTTTGGACATTCAGAGAGATGAATTGTGAGAACAGCAAAGAAATCCATCAGAAAAACAGAAAGAGGCAGACGTTTC CCAGGGCGTTCAGGCAGCCCTGATGGACCGAAGGCTCTGGTGTCTGGTTTGGCCCCACAGCAGTGTGGGCCGATCCTGTTTACCTCATAC ATCCCTGCACTGTGTGTTTTCATTTTTGTCTGCTTTAGTTCTCTTTTATTTTCTATTCACCACACACTCACCACTCCCAGCTTCTCGTGT CCAGTGAAACCCCTGAACCAAGATCACTGAATTTTTGTTTTTTTCTTGTTGCTTTGGGAAATTTTTTTTTCTCTGTAGGGTTTTTAAGAG GTTTCGGGGGTTTTGTTGTGTAAATATTCTATTTTATTCTTGGGGGGATCAAACCTTAGGAAAAGGATATCTATATATCTATATAGCTAT ATATTTGTGTTCCTTCAGGGAAACTGGTCTTGAAAAAGCAAGAAAAAAAAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCACCTT TTTATTTTTCCCATGACCAATTTGGGTCCCTTTGTCCATTTCTGGGGGTGCGTTGGGCAGCTGTGAGCCCAGCACATCGGATCCCTGGGG CTAGAGCCGCGGAGCCAATGAACTCAGGTGCTATGGGCCGGGCTGGGGCAGAGGGTGCATGCTGGGGTCCCACCGGCCAGGGGCCCCTGA CAGTGAATTGCTGACTGTGATATTCCACGATGCTTTTGCTTGTGCCGTGCTTGTCTGCTGGGCTCTCGAGTCAGGGGCCTGGAAATTTTT TTTTTTTTTTTTTTTTGAGACGGAGTTTTGCTCTTGTCGCCCAGGCTGGAGTGAGTGCAATGGTGCGATCTTGGCTCACTGCAACCTGCA CCTCCCAGGTGCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCAGTTAATTTTTGTATT TTTAGTAGAGATGGGGGTTTTGCCATGTTGGTCAGGCTGATCTCGAACTCCTGACCTCAGGTGATCTGCCCGCCTTGGCCTCCCAAAGTG CTGGGATTACAGGCATGAGCCGCCACGCTGGCCCGGTCTGGAAATCTTATCTAAAAAGTAGCAAGTGCTGGAAAAAGGGCCTGGGGGGCG GGGGTGGTTCTTGTCGAAGCCCCCAGGCTCCTGTCTCAGGGATGAATGTGGCGTCTCATTGGGATTCTTCTCTTGCCCGAAAGGGCTGCT TTTGAGGACTATCAATACTGGGGAGTGGGGGTGAAGCCGGACCTCACTCAGGGTGAGGATTTCAGGGCCCCGGCATCCTGAACACCCCCC ACACCCCAACATTCTCCTCGCTCTGTCCCTTCCTCTTCTCCCAACCCCTTTTGTGCTGGGGCTGCGAGCTCCCCGAGTTCTGCGGTGACT AAATCGAGGCCGAGAAGGGAGGCTGCCCCCCACCACCCTGTGGGTCAGTACCCCTCCCCCTGGCTTGGAGAAAGTGGGGTCACCGCAGCT GAGCTGGGGGGTTATTTTGGCTGGAGCTGCTGGAGCAGAAAGGCTGGGTCTGAAATGCCCAGCAGGGTCTGGGGACTTCGTTGGACCCGC GTGGTGTTGGGCGGGGCTGTCGTGTCCTACACGGGAGCTCTGGGCTTTCATTTCTCTTGGGGTGCAGTGGGGATTAACTCAGCTATTCCC AGGGTAAGCCTGGGTCTCTAATTGGGCCCTGGGAGCCCTGTTAGGCCACCGGCATGGGGGCTTGGTGAGGAAGGGGACTCCCCAGCTCCC CCCACTCCCAACCACCTCCCCATTGCCTTGGAGACCCCTGGGGAGGGGGCTGGGGGGCTTCTGAGCCCCTGAGTCTAGGTTCACTTTCCC GTCGGGCTGTGGGAGGGGACTGTCACTTTCCTGTGTCTTTGGGGAGGGGACCCCCACTTCCTTCTCGGATCTCAGGGCCGTGGACACACA CCCCCTTTCCAGGAGGGGGTGGTGGGCGTCTAGGTTTTCCTTGTCCCTTCCTGGGGCCAGCACCGTAGCAGCACAATCACCCCGGGAAGG GGGTGTCTGTTTGCCTCCAGACACAATCGGGCCCCACTCGCAGAACCACCTGGACTCTGTCCGTGTCTGTCCCCCGGCCTCCAGGGCTCC TCTCCCGGGACCCCCGTCCCACGCCTGGGCCCCGCGCCGGGGGAAGCGCCTGCTGCCTATCTCTGTCTACCTCAGGTCTGACTTTTGATG CCAAAATCTGAGCCCCTGGGGTGCCTCTCCCCCGCCTCCCGTGCACCAGGGTCTGCAGCAGCCACTGGGGCCTGGCTGCCTGCTGCATCT GGCGGCCCTGGACCCCTGGGGCCCCCGTGCACCTGCCCACCTCGGAGCCTGGGGAGGGGCCGTGCAGGGTCGAGGGCTGGGTCGTCTCCC TCGGGCTGCGTGTGTGTGTCGGGAATCCTGCGTGTCGTGTCTGTGGGCGATCCGGCCTCCCGGCGGTGGGTGGACCTGGATTCTAACTCA GAGGACTTGAGCCTGCTGTTAACTCCGATGATTGTAGGGACAGGCGGGGTGGGTGGGGGGTGGGCGCGAGGCTGGGTCCCGGCCCAGGAG AAGGAAGTCGCTGAAGGCAGTGGCCATGCTGGCCGTGGAAATGGGAGGCGGTTGCAGAGGGTCTATGGGGCCCGGTCCTGGATACTCGGC AGGAAGCCGTGTCTGCAGAGGCTCCTCCCTGCCTCAGGTGGCCCCGTTCAACCCCAGCCGTGCCCATCTCCTGCCACCGCCTGTCGGTGG GGGTTTAAATTCGGTGTGGCTTTCTGGGGTGCAGCTCAGCACCCCCCCTTATGCAGACTGGGAGGGGGTCGGGCAGTCCCCTCAGCCACG AGGACCCTGGATGGGTTCTAGTTCACTTGGGACCGTGGGGCCTGGCTGCGTACTGAGTGGGTGCCCCACAGTCAAGGCCAACGGGGGCTC CCCCTGCTCTGAGATGTTGGGAGAAAGGCGGCTTCTGGAACCTTCCGTGGGACCCGTAAGTGGCTGTCCAGAAAGGCGGGAGGGTGGGCA CGGGGCACGGGGGGCAGCTGGGGTCGTTGTTAAGGGTCACGCATCTGTACAGTTGAATTTCCTTTCTCTTATCATGTTTTACCCACCTTG TCCCTTTTTTCCCCAATTGTGCTTTTGCATTTTTTTCCTTGGCAAATGTAAACTCAGCCTTTCATTCATGACGTGTGAAATTTCAGTTTC TCTGGAGTTTGTCAGACGGCGTGGGAACCACGCCTGAAACTCAGGTAATAGGAGGAAAAAAAAAAAAACTTAAAAAAATTTTTAAAAAAC ATAAAACTACTCTCTACCTCTGGCTGGGCCCAGCCTGTCTCGCCCTGGCCGCGGCAGGGTGGCCTGTAACAATTTCAGTTTTCGCAGAAC ATTCAGGTATTAAAAGGAAAAAAAAAAAAAAAGACAAAAAGACCAAAAAAAAAAAAAAGTGTGATTTTGAAATTTAAAAGAACACTGAAA GTTTACATTTTATAGTAACATTATTATGCAGATTGTATTTAAACTTCAGAAATATTTAAGACGATTGTAACCCTGTAAAGCTGATGAGAT >In-frame_MIDN_ENST00000591446_chr19_1250528_+_ARID3A_ENST00000263620_chr19_971878_+_4704nt AGATCCTCCGAGCGGCGGCGACGGCTGTTGCTAAGGGAGGGGACGCGCGAGGAAGCGCGACCCGGGCGGCAGACGGCACCCAGCGCCACC AGCCGAGCGGCGCCCCCTCCCCAGGACCCTTAACCGCGCCGCGTCCCGGTCGCGCCCGCCGCCCTTTGAAGGAGAAGCAAGTGCCGTCCC CACCCCCGGAAGGCGCCCCCAGGAGCCGGAGCGACCTCGGAGCGCCACTCGGATTTTGGATTTCGGTCTCGCATTCCGCGGCCGGGACTT TCTCGAGGAGGACGCGCGCTGCTCCGCGCCCCCGAGTGCCCGGAGGACCCGGCATCCGGGGAGCCTCTCGCCCCTGTCCCGGAGGCGCGG CGAGGATTGGCGGCGCCCGCCGCCCCCAGCCCCCCAGCGCGCGCCGGGGATGGAGCCGCAGCCCGGCGGCGCCCGGAGCTGCCGGCGCGG GGCCCCCGGCGGCGCCTGCGAGCTGGGCCCGGCGGCCGAGGCGGCGCCCATGAGCCTCGCCATCCACAGCACCACGGGCACCCGCTACGA CCTGGCCGTGCCGCCCGACGAGACGGTGGAGGGGCTGCGCAAGCGGTTGTCCCAGCGCCTCAAAGTGCCCAAGGAGCGCCTGGCTCTTCT CCACAAAGACACGAGTTCTGTTTGCTCAGCCGCCGGCCCCCACGCCAACCTCTGCTCCCAACAAAGGAGGCGGCGGCGGCGGCGGCAGCA GCAGCAACGCAGGCGGCCGGGGAGGAAACACCGGAACCAGCGGCGGCCAGGCTGGGCCAGCGGGGCTGTCCACACCCTCCACATCTACCT CAAATAACTCGTTGCCTTAACCGCATCACTCCCCACCCGCCACCCACCCTGGAGCCCGCCGGCCTGGGCAGGGGGTCCAGGTGGGCCACA CAGGGGCCAGGATGGCGGAAGATACGGGTGGGGAGGGAAGATATCCAGAAAGGAGCCACAGCTGACGCCAAAAAGAAAAGAAAAAAGATA TATATATATATATATATATATACACGTATATATATAAAGAGAATTTAATAAAACAGGGGAAAACCAAGGAACACTTGAATTTCTCAGGTT TTGGACATTCAGAGAGATGAATTGTGAGAACAGCAAAGAAATCCATCAGAAAAACAGAAAGAGGCAGACGTTTCCCAGGGCGTTCAGGCA GCCCTGATGGACCGAAGGCTCTGGTGTCTGGTTTGGCCCCACAGCAGTGTGGGCCGATCCTGTTTACCTCATACATCCCTGCACTGTGTG TTTTCATTTTTGTCTGCTTTAGTTCTCTTTTATTTTCTATTCACCACACACTCACCACTCCCAGCTTCTCGTGTCCAGTGAAACCCCTGA ACCAAGATCACTGAATTTTTGTTTTTTTCTTGTTGCTTTGGGAAATTTTTTTTTCTCTGTAGGGTTTTTAAGAGGTTTCGGGGGTTTTGT TGTGTAAATATTCTATTTTATTCTTGGGGGGATCAAACCTTAGGAAAAGGATATCTATATATCTATATAGCTATATATTTGTGTTCCTTC AGGGAAACTGGTCTTGAAAAAGCAAGAAAAAAAAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCACCTTTTTATTTTTCCCATGA CCAATTTGGGTCCCTTTGTCCATTTCTGGGGGTGCGTTGGGCAGCTGTGAGCCCAGCACATCGGATCCCTGGGGCTAGAGCCGCGGAGCC AATGAACTCAGGTGCTATGGGCCGGGCTGGGGCAGAGGGTGCATGCTGGGGTCCCACCGGCCAGGGGCCCCTGACAGTGAATTGCTGACT GTGATATTCCACGATGCTTTTGCTTGTGCCGTGCTTGTCTGCTGGGCTCTCGAGTCAGGGGCCTGGAAATTTTTTTTTTTTTTTTTTTTT GAGACGGAGTTTTGCTCTTGTCGCCCAGGCTGGAGTGAGTGCAATGGTGCGATCTTGGCTCACTGCAACCTGCACCTCCCAGGTGCAAGC GATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCCAGTTAATTTTTGTATTTTTAGTAGAGATGGGG GTTTTGCCATGTTGGTCAGGCTGATCTCGAACTCCTGACCTCAGGTGATCTGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCAT GAGCCGCCACGCTGGCCCGGTCTGGAAATCTTATCTAAAAAGTAGCAAGTGCTGGAAAAAGGGCCTGGGGGGCGGGGGTGGTTCTTGTCG AAGCCCCCAGGCTCCTGTCTCAGGGATGAATGTGGCGTCTCATTGGGATTCTTCTCTTGCCCGAAAGGGCTGCTTTTGAGGACTATCAAT ACTGGGGAGTGGGGGTGAAGCCGGACCTCACTCAGGGTGAGGATTTCAGGGCCCCGGCATCCTGAACACCCCCCACACCCCAACATTCTC CTCGCTCTGTCCCTTCCTCTTCTCCCAACCCCTTTTGTGCTGGGGCTGCGAGCTCCCCGAGTTCTGCGGTGACTAAATCGAGGCCGAGAA GGGAGGCTGCCCCCCACCACCCTGTGGGTCAGTACCCCTCCCCCTGGCTTGGAGAAAGTGGGGTCACCGCAGCTGAGCTGGGGGGTTATT TTGGCTGGAGCTGCTGGAGCAGAAAGGCTGGGTCTGAAATGCCCAGCAGGGTCTGGGGACTTCGTTGGACCCGCGTGGTGTTGGGCGGGG CTGTCGTGTCCTACACGGGAGCTCTGGGCTTTCATTTCTCTTGGGGTGCAGTGGGGATTAACTCAGCTATTCCCAGGGTAAGCCTGGGTC TCTAATTGGGCCCTGGGAGCCCTGTTAGGCCACCGGCATGGGGGCTTGGTGAGGAAGGGGACTCCCCAGCTCCCCCCACTCCCAACCACC TCCCCATTGCCTTGGAGACCCCTGGGGAGGGGGCTGGGGGGCTTCTGAGCCCCTGAGTCTAGGTTCACTTTCCCGTCGGGCTGTGGGAGG GGACTGTCACTTTCCTGTGTCTTTGGGGAGGGGACCCCCACTTCCTTCTCGGATCTCAGGGCCGTGGACACACACCCCCTTTCCAGGAGG GGGTGGTGGGCGTCTAGGTTTTCCTTGTCCCTTCCTGGGGCCAGCACCGTAGCAGCACAATCACCCCGGGAAGGGGGTGTCTGTTTGCCT CCAGACACAATCGGGCCCCACTCGCAGAACCACCTGGACTCTGTCCGTGTCTGTCCCCCGGCCTCCAGGGCTCCTCTCCCGGGACCCCCG TCCCACGCCTGGGCCCCGCGCCGGGGGAAGCGCCTGCTGCCTATCTCTGTCTACCTCAGGTCTGACTTTTGATGCCAAAATCTGAGCCCC TGGGGTGCCTCTCCCCCGCCTCCCGTGCACCAGGGTCTGCAGCAGCCACTGGGGCCTGGCTGCCTGCTGCATCTGGCGGCCCTGGACCCC TGGGGCCCCCGTGCACCTGCCCACCTCGGAGCCTGGGGAGGGGCCGTGCAGGGTCGAGGGCTGGGTCGTCTCCCTCGGGCTGCGTGTGTG TGTCGGGAATCCTGCGTGTCGTGTCTGTGGGCGATCCGGCCTCCCGGCGGTGGGTGGACCTGGATTCTAACTCAGAGGACTTGAGCCTGC TGTTAACTCCGATGATTGTAGGGACAGGCGGGGTGGGTGGGGGGTGGGCGCGAGGCTGGGTCCCGGCCCAGGAGAAGGAAGTCGCTGAAG GCAGTGGCCATGCTGGCCGTGGAAATGGGAGGCGGTTGCAGAGGGTCTATGGGGCCCGGTCCTGGATACTCGGCAGGAAGCCGTGTCTGC AGAGGCTCCTCCCTGCCTCAGGTGGCCCCGTTCAACCCCAGCCGTGCCCATCTCCTGCCACCGCCTGTCGGTGGGGGTTTAAATTCGGTG TGGCTTTCTGGGGTGCAGCTCAGCACCCCCCCTTATGCAGACTGGGAGGGGGTCGGGCAGTCCCCTCAGCCACGAGGACCCTGGATGGGT TCTAGTTCACTTGGGACCGTGGGGCCTGGCTGCGTACTGAGTGGGTGCCCCACAGTCAAGGCCAACGGGGGCTCCCCCTGCTCTGAGATG TTGGGAGAAAGGCGGCTTCTGGAACCTTCCGTGGGACCCGTAAGTGGCTGTCCAGAAAGGCGGGAGGGTGGGCACGGGGCACGGGGGGCA GCTGGGGTCGTTGTTAAGGGTCACGCATCTGTACAGTTGAATTTCCTTTCTCTTATCATGTTTTACCCACCTTGTCCCTTTTTTCCCCAA TTGTGCTTTTGCATTTTTTTCCTTGGCAAATGTAAACTCAGCCTTTCATTCATGACGTGTGAAATTTCAGTTTCTCTGGAGTTTGTCAGA CGGCGTGGGAACCACGCCTGAAACTCAGGTAATAGGAGGAAAAAAAAAAAAACTTAAAAAAATTTTTAAAAAACATAAAACTACTCTCTA CCTCTGGCTGGGCCCAGCCTGTCTCGCCCTGGCCGCGGCAGGGTGGCCTGTAACAATTTCAGTTTTCGCAGAACATTCAGGTATTAAAAG GAAAAAAAAAAAAAAAGACAAAAAGACCAAAAAAAAAAAAAAGTGTGATTTTGAAATTTAAAAGAACACTGAAAGTTTACATTTTATAGT AACATTATTATGCAGATTGTATTTAAACTTCAGAAATATTTAAGACGATTGTAACCCTGTAAAGCTGATGAGATATTAAAACGAGACAAA |
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FusionGenePPI for MIDN_ARID3A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MIDN | GADD45G, GADD45A, ZAK, ELAVL1, PSMC1, EGR1, NR4A1, ERCC6L | ARID3A | BTK, E2F1, ELAVL1, UBC, SP100, UBE2E3, PML, TP53, E2F2, E2F4, APP, TP53BP1, SOX2, TTC32, NOTCH2NL, FOXB1, FOXH1, FOXL1, NANOG, ARID3C, ARID3B, ZBED8, HERC2, LCN15, KIAA0430, HELZ, SOWAHA, EIF4ENIF1, PAN2, PCGF3, NISCH |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MIDN_ARID3A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIDN_ARID3A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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