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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21921

FusionGeneSummary for MICU1_TSPAN3

check button Fusion gene summary
Fusion gene informationFusion gene name: MICU1_TSPAN3
Fusion gene ID: 21921
HgeneTgene
Gene symbol

MICU1

TSPAN3

Gene ID

10367

10099

Gene namemitochondrial calcium uptake 1tetraspanin 3
SynonymsCALC|CBARA1|EFHA3|MPXPS|ara CALCTM4-A|TM4SF8|TSPAN-3
Cytomap

10q22.1

15q24.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1tetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8
Modification date2018052420180523
UniProtAcc

Q9BPX6

O60637

Ensembl transtripts involved in fusion geneENST00000401998, ENST00000361114, 
ENST00000398761, ENST00000418483, 
ENST00000398763, ENST00000604025, 
ENST00000267970, ENST00000346495, 
ENST00000424443, ENST00000561277, 
ENST00000559494, ENST00000558745, 
ENST00000558394, 
Fusion gene scores* DoF score6 X 4 X 6=1446 X 5 X 4=120
# samples 77
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICU1 [Title/Abstract] AND TSPAN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICU1

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

HgeneMICU1

GO:0051260

protein homooligomerization

24514027

HgeneMICU1

GO:0051561

positive regulation of mitochondrial calcium ion concentration

24560927

HgeneMICU1

GO:0070509

calcium ion import

20693986


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03P-01AMICU1chr10

74293504

-TSPAN3chr15

77348597

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000401998ENST00000267970MICU1chr10

74293504

-TSPAN3chr15

77348597

-
Frame-shiftENST00000401998ENST00000346495MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-intronENST00000401998ENST00000424443MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000401998ENST00000561277MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-intronENST00000401998ENST00000559494MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000401998ENST00000558745MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000401998ENST00000558394MICU1chr10

74293504

-TSPAN3chr15

77348597

-
Frame-shiftENST00000361114ENST00000267970MICU1chr10

74293504

-TSPAN3chr15

77348597

-
Frame-shiftENST00000361114ENST00000346495MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-intronENST00000361114ENST00000424443MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000361114ENST00000561277MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-intronENST00000361114ENST00000559494MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000361114ENST00000558745MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000361114ENST00000558394MICU1chr10

74293504

-TSPAN3chr15

77348597

-
Frame-shiftENST00000398761ENST00000267970MICU1chr10

74293504

-TSPAN3chr15

77348597

-
Frame-shiftENST00000398761ENST00000346495MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-intronENST00000398761ENST00000424443MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000398761ENST00000561277MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-intronENST00000398761ENST00000559494MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000398761ENST00000558745MICU1chr10

74293504

-TSPAN3chr15

77348597

-
5CDS-5UTRENST00000398761ENST00000558394MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-3CDSENST00000418483ENST00000267970MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-3CDSENST00000418483ENST00000346495MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-intronENST00000418483ENST00000424443MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000418483ENST00000561277MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-intronENST00000418483ENST00000559494MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000418483ENST00000558745MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000418483ENST00000558394MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-3CDSENST00000398763ENST00000267970MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-3CDSENST00000398763ENST00000346495MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-intronENST00000398763ENST00000424443MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000398763ENST00000561277MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-intronENST00000398763ENST00000559494MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000398763ENST00000558745MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000398763ENST00000558394MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-3CDSENST00000604025ENST00000267970MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-3CDSENST00000604025ENST00000346495MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-intronENST00000604025ENST00000424443MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000604025ENST00000561277MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-intronENST00000604025ENST00000559494MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000604025ENST00000558745MICU1chr10

74293504

-TSPAN3chr15

77348597

-
intron-5UTRENST00000604025ENST00000558394MICU1chr10

74293504

-TSPAN3chr15

77348597

-

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FusionProtFeatures for MICU1_TSPAN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICU1

Q9BPX6

TSPAN3

O60637

Regulates the proliferation and migration ofoligodendrocytes, a process essential for normal myelination andrepair. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MICU1_TSPAN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MICU1_TSPAN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MICU1BABAM1, APP, MAGEA1, SLC18A1, MICU2, TBC1D22A, CPVL, COQ9, MICU3, KLHL22, CD79A, GPN3, SLC39A12, THUMPD3, PCDHB11, ARL10, ANGEL1, TRIM44, CDH5, FAM131B, CD79B, TUBA1B, DCAF11, DOCK5, RANBP6, AARS, AURKBTSPAN3EWSR1, FAM189B, NDFIP2, NDFIP1, NOTCH3, CDC6, GABARAP, STX6, AGPAT3, SDCBP, CD320, KDSR, EPHA5, EPHA4, MAP1LC3B2, RNF149, CC2D1A, FGFR1, FGFR2, TNFRSF10B, UGCG, GOLGA7, SNX17, ZDHHC9, CSNK1G3, IFNGR1, ACVR1B, RDH14, PI4K2A, CD63, ARL17A, LRP10, RNF13, LPAR1, LRRC8B, SPPL2B, TSPAN2, LGALS9, GPR141, TRHDE, ABCG8, GPR114, TMEM30B, TMEM171, GPM6A, MANSC1, GPR21, TACR1, LGALS9C, EFNB2, LMAN2L, ADIPOR1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MICU1_TSPAN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MICU1_TSPAN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMICU1C0004782Basal Ganglia Diseases1CTD_human
HgeneMICU1C0023186Learning Disorders1CTD_human
HgeneMICU1C0026650Movement Disorders1CTD_human
HgeneMICU1C0026848Myopathy1CTD_human