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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2192

FusionGeneSummary for APLP2_ZNF652

check button Fusion gene summary
Fusion gene informationFusion gene name: APLP2_ZNF652
Fusion gene ID: 2192
HgeneTgene
Gene symbol

APLP2

ZNF652

Gene ID

334

22834

Gene nameamyloid beta precursor like protein 2zinc finger protein 652
SynonymsAPLP-2|APPH|APPL2|CDEBP-
Cytomap

11q24.3

17q21.32-q21.33

Type of geneprotein-codingprotein-coding
Descriptionamyloid-like protein 2CDEI box-binding proteinamyloid beta (A4) precursor-like protein 2amyloid precursor protein homolog HSD-2testicular tissue protein Li 23zinc finger protein 652
Modification date2018051920180523
UniProtAcc

Q06481

Q9Y2D9

Ensembl transtripts involved in fusion geneENST00000532456, ENST00000539648, 
ENST00000528499, ENST00000263574, 
ENST00000345598, ENST00000338167, 
ENST00000278756, ENST00000543137, 
ENST00000513488, ENST00000362063, 
ENST00000430262, 
Fusion gene scores* DoF score24 X 17 X 11=44886 X 5 X 2=60
# samples 296
** MAII scorelog2(29/4488*10)=-3.95194787059386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: APLP2 [Title/Abstract] AND ZNF652 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI985209APLP2chr11

129939782

-ZNF652chr17

47367249

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000532456ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
3UTR-intronENST00000532456ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
3UTR-intronENST00000532456ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000539648ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000539648ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000539648ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000528499ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000528499ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000528499ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000263574ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000263574ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000263574ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000345598ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000345598ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000345598ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000338167ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000338167ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000338167ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000278756ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000278756ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000278756ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000543137ENST00000513488APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000543137ENST00000362063APLP2chr11

129939782

-ZNF652chr17

47367249

-
intron-intronENST00000543137ENST00000430262APLP2chr11

129939782

-ZNF652chr17

47367249

-

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FusionProtFeatures for APLP2_ZNF652


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APLP2

Q06481

ZNF652

Q9Y2D9

Functions as a transcriptional repressor.{ECO:0000269|PubMed:16966434}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for APLP2_ZNF652


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for APLP2_ZNF652


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for APLP2_ZNF652


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneAPLP2Q06481DB01593ZincAmyloid-like protein 2small moleculeapproved|investigational

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RelatedDiseases for APLP2_ZNF652


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPLP2C0027746Nerve Degeneration1CTD_human
HgeneAPLP2C0151744Myocardial Ischemia1CTD_human