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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21911

FusionGeneSummary for MICB_PCDH11Y

check button Fusion gene summary
Fusion gene informationFusion gene name: MICB_PCDH11Y
Fusion gene ID: 21911
HgeneTgene
Gene symbol

MICB

PCDH11Y

Gene ID

4277

83259

Gene nameMHC class I polypeptide-related sequence Bprotocadherin 11 Y-linked
SynonymsPERB11.2PCDH-PC|PCDH22|PCDHX|PCDHY
Cytomap

6p21.33

Yp11.2

Type of geneprotein-codingprotein-coding
DescriptionMHC class I polypeptide-related sequence BMHC class I chain-related protein BMHC class I mic-B antigenMHC class I-like molecule PERB11.2-IMXstress inducible class I homologprotocadherin-11 Y-linkedprotocadherin 22protocadherin on the Y chromosomeprotocadherin prostate cancerprotocadherin-PC
Modification date2018052320180523
UniProtAcc

Q29980

Q9BZA8

Ensembl transtripts involved in fusion geneENST00000538442, ENST00000399150, 
ENST00000252229, ENST00000427115, 
ENST00000442104, ENST00000451603, 
ENST00000546706, ENST00000438954, 
ENST00000458032, ENST00000551950, 
ENST00000437651, ENST00000383514, 
ENST00000551608, ENST00000436531, 
ENST00000436655, ENST00000547574, 
ENST00000400313, ENST00000428416, 
ENST00000549014, ENST00000428059, 
ENST00000451789, ENST00000443156, 
ENST00000551960, 
ENST00000215473, 
ENST00000333703, ENST00000362095, 
Fusion gene scores* DoF score8 X 8 X 1=641 X 1 X 1=1
# samples 81
** MAII scorelog2(8/64*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: MICB [Title/Abstract] AND PCDH11Y [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICB

GO:0002429

immune response-activating cell surface receptor signaling pathway

11491531

HgeneMICB

GO:0006979

response to oxidative stress

11287116

HgeneMICB

GO:0009408

response to heat

9497295

HgeneMICB

GO:0032526

response to retinoic acid

12569559

HgeneMICB

GO:0046629

gamma-delta T cell activation

9497295

HgeneMICB

GO:0050689

negative regulation of defense response to virus by host

11239445|12782710


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM785679MICBchr6

2586313

-PCDH11YchrY

5207021

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000538442ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000538442ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000538442ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000399150ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000399150ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000399150ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000252229ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000252229ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000252229ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000427115ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000427115ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000427115ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000442104ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000442104ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000442104ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000451603ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000451603ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000451603ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000546706ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000546706ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000546706ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000438954ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000438954ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000438954ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000458032ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000458032ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000458032ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551950ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551950ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551950ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000437651ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000437651ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000437651ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000383514ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000383514ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000383514ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551608ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551608ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551608ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000436531ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000436531ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000436531ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000436655ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000436655ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000436655ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000547574ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000547574ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000547574ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000400313ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000400313ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000400313ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000428416ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000428416ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000428416ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000549014ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000549014ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000549014ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000428059ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000428059ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000428059ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000451789ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000451789ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000451789ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000443156ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000443156ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000443156ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551960ENST00000215473MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551960ENST00000333703MICBchr6

2586313

-PCDH11YchrY

5207021

-
intron-intronENST00000551960ENST00000362095MICBchr6

2586313

-PCDH11YchrY

5207021

-

Top

FusionProtFeatures for MICB_PCDH11Y


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICB

Q29980

PCDH11Y

Q9BZA8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MICB_PCDH11Y


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MICB_PCDH11Y


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MICB_PCDH11Y


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MICB_PCDH11Y


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMICBC0019100Severe Dengue1CTD_human
HgeneMICBC0036341Schizophrenia1PSYGENET
TgenePCDH11YC0033578Prostatic Neoplasms1CTD_human
TgenePCDH11YC0033975Psychotic Disorders1PSYGENET
TgenePCDH11YC0036337Schizoaffective Disorder1PSYGENET
TgenePCDH11YC0349204Nonorganic psychosis1PSYGENET