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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21908

FusionGeneSummary for MICB_BCL11B

check button Fusion gene summary
Fusion gene informationFusion gene name: MICB_BCL11B
Fusion gene ID: 21908
HgeneTgene
Gene symbol

MICB

BCL11B

Gene ID

4277

64919

Gene nameMHC class I polypeptide-related sequence BB cell CLL/lymphoma 11B
SynonymsPERB11.2ATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IMD49|RIT1|ZNF856B|hRIT1-alpha
Cytomap

6p21.33

14q32.2

Type of geneprotein-codingprotein-coding
DescriptionMHC class I polypeptide-related sequence BMHC class I chain-related protein BMHC class I mic-B antigenMHC class I-like molecule PERB11.2-IMXstress inducible class I homologB-cell lymphoma/leukemia 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B/TRDC fusionCOUP-TF-interacting protein 2hRit1radiation-
Modification date2018052320180523
UniProtAcc

Q29980

Q9C0K0

Ensembl transtripts involved in fusion geneENST00000538442, ENST00000399150, 
ENST00000252229, ENST00000427115, 
ENST00000442104, ENST00000451603, 
ENST00000546706, ENST00000438954, 
ENST00000458032, ENST00000551950, 
ENST00000437651, ENST00000383514, 
ENST00000551608, ENST00000436531, 
ENST00000436655, ENST00000547574, 
ENST00000400313, ENST00000428416, 
ENST00000549014, ENST00000428059, 
ENST00000451789, ENST00000443156, 
ENST00000551960, 
ENST00000357195, 
ENST00000345514, ENST00000443726, 
Fusion gene scores* DoF score8 X 8 X 1=642 X 3 X 1=6
# samples 813
** MAII scorelog2(8/64*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(13/6*10)=4.4374053123073
Context

PubMed: MICB [Title/Abstract] AND BCL11B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICB

GO:0002429

immune response-activating cell surface receptor signaling pathway

11491531

HgeneMICB

GO:0006979

response to oxidative stress

11287116

HgeneMICB

GO:0009408

response to heat

9497295

HgeneMICB

GO:0032526

response to retinoic acid

12569559

HgeneMICB

GO:0046629

gamma-delta T cell activation

9497295

HgeneMICB

GO:0050689

negative regulation of defense response to virus by host

11239445|12782710


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EL582473MICBchr6

2586310

-BCL11Bchr14

99655805

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000538442ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000538442ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000538442ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000399150ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000399150ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000399150ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000252229ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000252229ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000252229ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000427115ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000427115ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000427115ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000442104ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000442104ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000442104ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000451603ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000451603ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000451603ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000546706ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000546706ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000546706ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000438954ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000438954ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000438954ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000458032ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000458032ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000458032ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551950ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551950ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551950ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000437651ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000437651ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000437651ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000383514ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000383514ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000383514ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551608ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551608ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551608ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000436531ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000436531ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000436531ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000436655ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000436655ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000436655ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000547574ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000547574ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000547574ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000400313ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000400313ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000400313ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000428416ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000428416ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000428416ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000549014ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000549014ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000549014ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000428059ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000428059ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000428059ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000451789ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000451789ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000451789ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000443156ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000443156ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000443156ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551960ENST00000357195MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551960ENST00000345514MICBchr6

2586310

-BCL11Bchr14

99655805

-
intron-intronENST00000551960ENST00000443726MICBchr6

2586310

-BCL11Bchr14

99655805

-

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FusionProtFeatures for MICB_BCL11B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICB

Q29980

BCL11B

Q9C0K0

Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential incontrolling the responsiveness of hematopoietic stem cells tochemotactic signals by modulating the expression of the receptorsCCR7 and CCR9, which direct the movement of progenitor cells fromthe bone marrow to the thymus (PubMed:27959755). Is a regulator ofIL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that repressestranscription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in theP53-signaling pathway (By similarity).{ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611,ECO:0000269|PubMed:27959755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MICB_BCL11B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MICB_BCL11B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MICB_BCL11B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MICB_BCL11B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMICBC0019100Severe Dengue1CTD_human
HgeneMICBC0036341Schizophrenia1PSYGENET
TgeneBCL11BC0024299Lymphoma1CTD_human
TgeneBCL11BC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human