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Fusion gene ID: 21887 |
FusionGeneSummary for MICAL3_SLC1A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MICAL3_SLC1A3 | Fusion gene ID: 21887 | Hgene | Tgene | Gene symbol | MICAL3 | SLC1A3 | Gene ID | 57553 | 6507 |
| Gene name | microtubule associated monooxygenase, calponin and LIM domain containing 3 | solute carrier family 1 member 3 | |
| Synonyms | MICAL-3 | EA6|EAAT1|GLAST|GLAST1 | |
| Cytomap | 22q11.21 | 5p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | [F-actin]-monooxygenase MICAL3F-actin-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3 | excitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q7RTP6 | P43003 | |
| Ensembl transtripts involved in fusion gene | ENST00000441493, ENST00000400561, ENST00000444520, ENST00000414725, ENST00000383094, ENST00000207726, ENST00000429452, ENST00000585038, ENST00000580469, | ENST00000265113, ENST00000506725, ENST00000381918, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 10 X 9 X 6=540 |
| # samples | 10 | 12 | |
| ** MAII score | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MICAL3 [Title/Abstract] AND SLC1A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MICAL3 | GO:0007010 | cytoskeleton organization | 24440334 |
| Hgene | MICAL3 | GO:0030042 | actin filament depolymerization | 24440334 |
| Tgene | SLC1A3 | GO:0015813 | L-glutamate transmembrane transport | 26690923 |
| Tgene | SLC1A3 | GO:0051938 | L-glutamate import | 7521911 |
| Tgene | SLC1A3 | GO:0070779 | D-aspartate import across plasma membrane | 7521911 |
| Tgene | SLC1A3 | GO:0071805 | potassium ion transmembrane transport | 20477940 |
| Tgene | SLC1A3 | GO:0098712 | L-glutamate import across plasma membrane | 26690923 |
| Tgene | SLC1A3 | GO:0140009 | L-aspartate import across plasma membrane | 20477940 |
| Tgene | SLC1A3 | GO:1902476 | chloride transmembrane transport | 20477940 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE936478 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000441493 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000441493 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000441493 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000400561 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000400561 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000400561 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000444520 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000444520 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000444520 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000414725 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000414725 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000414725 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000383094 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000383094 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000383094 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000207726 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000207726 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000207726 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000429452 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000429452 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000429452 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000585038 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000585038 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000585038 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000580469 | ENST00000265113 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000580469 | ENST00000506725 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
| intron-intron | ENST00000580469 | ENST00000381918 | MICAL3 | chr22 | 18272609 | - | SLC1A3 | chr5 | 36662106 | - |
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FusionProtFeatures for MICAL3_SLC1A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MICAL3 | SLC1A3 |
| Monooxygenase that promotes depolymerization of F-actinby mediating oxidation of specific methionine residues on actin toform methionine-sulfoxide, resulting in actin filament disassemblyand preventing repolymerization. In the absence of actin, it alsofunctions as a NADPH oxidase producing H(2)O(2). Seems to act asRab effector protein and plays a role in vesicle trafficking.Involved in exocytic vesicles tethering and fusion: themonooxygenase activity is required for this process and implicatesRAB8A associated with exocytotic vesicles. Required forcytokinesis. Contributes to stabilization and/or maturation of theintercellular bridge independently of its monooxygenase activity.Promotes recruitment of Rab8 and ERC1 to the intercellular bridge,and together these proteins are proposed to function in timelyabscission. {ECO:0000269|PubMed:21596566,ECO:0000269|PubMed:24440334}. | Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940,PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as asymporter that transports one amino acid molecule together withtwo or three Na(+) ions and one proton, in parallel with thecounter-transport of one K(+) ion (PubMed:20477940). MediatesCl(-) flux that is not coupled to amino acid transport; thisavoids the accumulation of negative charges due to aspartate andNa(+) symport (PubMed:20477940). Plays a redundant role in therapid removal of released glutamate from the synaptic cleft, whichis essential for terminating the postsynaptic action of glutamate(By similarity). {ECO:0000250|UniProtKB:P56564,ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515,ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MICAL3_SLC1A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MICAL3_SLC1A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MICAL3_SLC1A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SLC1A3 | P43003 | DB00142 | Glutamic Acid | Excitatory amino acid transporter 1 {ECO:0000303|PubMed:16042756, ECO:0000303|PubMed:8647279} | small molecule | approved|nutraceutical |
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RelatedDiseases for MICAL3_SLC1A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SLC1A3 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Tgene | SLC1A3 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | SLC1A3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | SLC1A3 | C0014544 | Epilepsy | 1 | CTD_human;HPO |
| Tgene | SLC1A3 | C0178417 | Anhedonia | 1 | PSYGENET |
| Tgene | SLC1A3 | C2675211 | EPISODIC ATAXIA, TYPE 6 (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
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