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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21884

FusionGeneSummary for MICAL3_MICAL3

check button Fusion gene summary
Fusion gene informationFusion gene name: MICAL3_MICAL3
Fusion gene ID: 21884
HgeneTgene
Gene symbol

MICAL3

MICAL3

Gene ID

57553

57553

Gene namemicrotubule associated monooxygenase, calponin and LIM domain containing 3microtubule associated monooxygenase, calponin and LIM domain containing 3
SynonymsMICAL-3MICAL-3
Cytomap

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
Description[F-actin]-monooxygenase MICAL3F-actin-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3[F-actin]-monooxygenase MICAL3F-actin-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3
Modification date2018051920180519
UniProtAcc

Q7RTP6

Q7RTP6

Ensembl transtripts involved in fusion geneENST00000441493, ENST00000400561, 
ENST00000444520, ENST00000414725, 
ENST00000383094, ENST00000207726, 
ENST00000429452, ENST00000585038, 
ENST00000580469, 
ENST00000441493, 
ENST00000400561, ENST00000444520, 
ENST00000414725, ENST00000383094, 
ENST00000207726, ENST00000429452, 
ENST00000585038, ENST00000580469, 
Fusion gene scores* DoF score9 X 6 X 7=3783 X 3 X 1=9
# samples 103
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MICAL3 [Title/Abstract] AND MICAL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICAL3

GO:0007010

cytoskeleton organization

24440334

HgeneMICAL3

GO:0030042

actin filament depolymerization

24440334

TgeneMICAL3

GO:0007010

cytoskeleton organization

24440334

TgeneMICAL3

GO:0030042

actin filament depolymerization

24440334


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE141862MICAL3chr22

18324588

-MICAL3chr22

18374369

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000441493ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000441493ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000441493ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000441493ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000441493ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000441493ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000441493ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000441493ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
5CDS-intronENST00000441493ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
Frame-shiftENST00000400561ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
5CDS-intronENST00000400561ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
In-frameENST00000444520ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
5CDS-intronENST00000444520ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000414725ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-intronENST00000414725ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000383094ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-intronENST00000383094ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000207726ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-intronENST00000207726ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000429452ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-intronENST00000429452ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000585038ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-intronENST00000585038ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000441493MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000400561MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000444520MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000414725MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000383094MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000207726MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000429452MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-3CDSENST00000580469ENST00000585038MICAL3chr22

18324588

-MICAL3chr22

18374369

+
intron-intronENST00000580469ENST00000580469MICAL3chr22

18324588

-MICAL3chr22

18374369

+

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FusionProtFeatures for MICAL3_MICAL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICAL3

Q7RTP6

MICAL3

Q7RTP6

Monooxygenase that promotes depolymerization of F-actinby mediating oxidation of specific methionine residues on actin toform methionine-sulfoxide, resulting in actin filament disassemblyand preventing repolymerization. In the absence of actin, it alsofunctions as a NADPH oxidase producing H(2)O(2). Seems to act asRab effector protein and plays a role in vesicle trafficking.Involved in exocytic vesicles tethering and fusion: themonooxygenase activity is required for this process and implicatesRAB8A associated with exocytotic vesicles. Required forcytokinesis. Contributes to stabilization and/or maturation of theintercellular bridge independently of its monooxygenase activity.Promotes recruitment of Rab8 and ERC1 to the intercellular bridge,and together these proteins are proposed to function in timelyabscission. {ECO:0000269|PubMed:21596566,ECO:0000269|PubMed:24440334}. Monooxygenase that promotes depolymerization of F-actinby mediating oxidation of specific methionine residues on actin toform methionine-sulfoxide, resulting in actin filament disassemblyand preventing repolymerization. In the absence of actin, it alsofunctions as a NADPH oxidase producing H(2)O(2). Seems to act asRab effector protein and plays a role in vesicle trafficking.Involved in exocytic vesicles tethering and fusion: themonooxygenase activity is required for this process and implicatesRAB8A associated with exocytotic vesicles. Required forcytokinesis. Contributes to stabilization and/or maturation of theintercellular bridge independently of its monooxygenase activity.Promotes recruitment of Rab8 and ERC1 to the intercellular bridge,and together these proteins are proposed to function in timelyabscission. {ECO:0000269|PubMed:21596566,ECO:0000269|PubMed:24440334}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MICAL3_MICAL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MICAL3_MICAL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MICAL3_MICAL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MICAL3_MICAL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource