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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21880

FusionGeneSummary for MICAL2_VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: MICAL2_VMP1
Fusion gene ID: 21880
HgeneTgene
Gene symbol

MICAL2

VMP1

Gene ID

9645

81671

Gene namemicrotubule associated monooxygenase, calponin and LIM domain containing 2vacuole membrane protein 1
SynonymsMICAL-2|MICAL2PV1|MICAL2PV2EPG3|TANGO5|TMEM49
Cytomap

11p15.3

17q23.1

Type of geneprotein-codingprotein-coding
Description[F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxidevacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2018051920180523
UniProtAcc

O94851

Q96GC9

Ensembl transtripts involved in fusion geneENST00000537344, ENST00000256194, 
ENST00000527546, ENST00000342902, 
ENST00000379612, ENST00000527195, 
ENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
Fusion gene scores* DoF score5 X 4 X 3=6024 X 11 X 12=3168
# samples 627
** MAII scorelog2(6/60*10)=0log2(27/3168*10)=-3.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MICAL2 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICAL2

GO:0007010

cytoskeleton organization

24440334

HgeneMICAL2

GO:0030042

actin filament depolymerization

24440334

HgeneMICAL2

GO:0055114

oxidation-reduction process

24440334


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA601529MICAL2chr11

12241011

-VMP1chr17

57916409

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000537344ENST00000262291MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000537344ENST00000537567MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000537344ENST00000539763MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000537344ENST00000536180MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000537344ENST00000545362MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000537344ENST00000588617MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000256194ENST00000262291MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000256194ENST00000537567MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000256194ENST00000539763MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000256194ENST00000536180MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000256194ENST00000545362MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000256194ENST00000588617MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527546ENST00000262291MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527546ENST00000537567MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527546ENST00000539763MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527546ENST00000536180MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527546ENST00000545362MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527546ENST00000588617MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000342902ENST00000262291MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000342902ENST00000537567MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000342902ENST00000539763MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000342902ENST00000536180MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000342902ENST00000545362MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000342902ENST00000588617MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000379612ENST00000262291MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000379612ENST00000537567MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000379612ENST00000539763MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000379612ENST00000536180MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000379612ENST00000545362MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000379612ENST00000588617MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527195ENST00000262291MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527195ENST00000537567MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527195ENST00000539763MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527195ENST00000536180MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527195ENST00000545362MICAL2chr11

12241011

-VMP1chr17

57916409

-
intron-intronENST00000527195ENST00000588617MICAL2chr11

12241011

-VMP1chr17

57916409

-

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FusionProtFeatures for MICAL2_VMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICAL2

O94851

VMP1

Q96GC9

Nuclear monooxygenase that promotes depolymerization ofF-actin by mediating oxidation of specific methionine residues onactin to form methionine-sulfoxide, resulting in actin filamentdisassembly and preventing repolymerization. In the absence ofactin, it also functions as a NADPH oxidase producing H(2)O(2) (Bysimilarity). Acts as a key regulator of the SRF signaling pathwayelicited by nerve growth factor and serum: mediates oxidation andsubsequent depolymerization of nuclear actin, leading to increaseMKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-Athrough RhoA. {ECO:0000250|UniProtKB:Q8BML1,ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}. Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MICAL2_VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MICAL2_VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MICAL2_VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MICAL2_VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource