FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 21879

FusionGeneSummary for MICAL2_RRAS2

check button Fusion gene summary
Fusion gene informationFusion gene name: MICAL2_RRAS2
Fusion gene ID: 21879
HgeneTgene
Gene symbol

MICAL2

RRAS2

Gene ID

9645

22800

Gene namemicrotubule associated monooxygenase, calponin and LIM domain containing 2RAS related 2
SynonymsMICAL-2|MICAL2PV1|MICAL2PV2TC21
Cytomap

11p15.3

11p15.2

Type of geneprotein-codingprotein-coding
Description[F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxideras-related protein R-Ras2ras-like protein TC21related RAS viral (r-ras) oncogene homolog 2teratocarcinoma oncogene
Modification date2018051920180519
UniProtAcc

O94851

P62070

Ensembl transtripts involved in fusion geneENST00000537344, ENST00000256194, 
ENST00000527546, ENST00000342902, 
ENST00000379612, ENST00000527195, 
ENST00000545643, ENST00000537760, 
ENST00000414023, ENST00000529237, 
ENST00000256196, ENST00000534746, 
ENST00000526063, ENST00000532814, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 1 X 3=9
# samples 63
** MAII scorelog2(6/60*10)=0log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MICAL2 [Title/Abstract] AND RRAS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMICAL2

GO:0007010

cytoskeleton organization

24440334

HgeneMICAL2

GO:0030042

actin filament depolymerization

24440334

HgeneMICAL2

GO:0055114

oxidation-reduction process

24440334


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-FD-A6TD-01AMICAL2chr11

12261132

+RRAS2chr11

14317401

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000537344ENST00000545643MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000537344ENST00000537760MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000537344ENST00000414023MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000537344ENST00000529237MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000537344ENST00000256196MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000537344ENST00000534746MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000537344ENST00000526063MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000537344ENST00000532814MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000256194ENST00000545643MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000256194ENST00000537760MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000256194ENST00000414023MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000256194ENST00000529237MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000256194ENST00000256196MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000256194ENST00000534746MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000256194ENST00000526063MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000256194ENST00000532814MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000527546ENST00000545643MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000527546ENST00000537760MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000527546ENST00000414023MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527546ENST00000529237MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527546ENST00000256196MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527546ENST00000534746MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527546ENST00000526063MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000527546ENST00000532814MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000342902ENST00000545643MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000342902ENST00000537760MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000342902ENST00000414023MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000342902ENST00000529237MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000342902ENST00000256196MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000342902ENST00000534746MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000342902ENST00000526063MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000342902ENST00000532814MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000379612ENST00000545643MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000379612ENST00000537760MICAL2chr11

12261132

+RRAS2chr11

14317401

-
In-frameENST00000379612ENST00000414023MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000379612ENST00000529237MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000379612ENST00000256196MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000379612ENST00000534746MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000379612ENST00000526063MICAL2chr11

12261132

+RRAS2chr11

14317401

-
5CDS-5UTRENST00000379612ENST00000532814MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-3CDSENST00000527195ENST00000545643MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-3CDSENST00000527195ENST00000537760MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-3CDSENST00000527195ENST00000414023MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-5UTRENST00000527195ENST00000529237MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-5UTRENST00000527195ENST00000256196MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-5UTRENST00000527195ENST00000534746MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-5UTRENST00000527195ENST00000526063MICAL2chr11

12261132

+RRAS2chr11

14317401

-
intron-5UTRENST00000527195ENST00000532814MICAL2chr11

12261132

+RRAS2chr11

14317401

-

Top

FusionProtFeatures for MICAL2_RRAS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MICAL2

O94851

RRAS2

P62070

Nuclear monooxygenase that promotes depolymerization ofF-actin by mediating oxidation of specific methionine residues onactin to form methionine-sulfoxide, resulting in actin filamentdisassembly and preventing repolymerization. In the absence ofactin, it also functions as a NADPH oxidase producing H(2)O(2) (Bysimilarity). Acts as a key regulator of the SRF signaling pathwayelicited by nerve growth factor and serum: mediates oxidation andsubsequent depolymerization of nuclear actin, leading to increaseMKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-Athrough RhoA. {ECO:0000250|UniProtKB:Q8BML1,ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}. It is a plasma membrane-associated GTP-binding proteinwith GTPase activity. Might transduce growth inhibitory signalsacross the cell membrane, exerting its effect through an effectorshared with the Ras proteins but in an antagonistic fashion.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICAL2chr11:12261132chr11:14317401ENST00000256194+1728516_6197381155DomainCalponin-homology (CH)
HgeneMICAL2chr11:12261132chr11:14317401ENST00000342902+1626516_6197381099DomainCalponin-homology (CH)
HgeneMICAL2chr11:12261132chr11:14317401ENST00000379612+1519516_619738977DomainCalponin-homology (CH)
HgeneMICAL2chr11:12261132chr11:14317401ENST00000527546+1622516_619738935DomainCalponin-homology (CH)
HgeneMICAL2chr11:12261132chr11:14317401ENST00000537344+1723516_619738935DomainCalponin-homology (CH)
HgeneMICAL2chr11:12261132chr11:14317401ENST00000256194+1728660_6817381155MotifNuclear localization signal
HgeneMICAL2chr11:12261132chr11:14317401ENST00000342902+1626660_6817381099MotifNuclear localization signal
HgeneMICAL2chr11:12261132chr11:14317401ENST00000379612+1519660_681738977MotifNuclear localization signal
HgeneMICAL2chr11:12261132chr11:14317401ENST00000527546+1622660_681738935MotifNuclear localization signal
HgeneMICAL2chr11:12261132chr11:14317401ENST00000537344+1723660_681738935MotifNuclear localization signal
HgeneMICAL2chr11:12261132chr11:14317401ENST00000256194+1728116_1187381155Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000256194+1728123_1257381155Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000342902+1626116_1187381099Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000342902+1626123_1257381099Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000379612+1519116_118738977Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000379612+1519123_125738977Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000527546+1622116_118738935Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000527546+1622123_125738935Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000537344+1723116_118738935Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000537344+1723123_125738935Nucleotide bindingFAD
HgeneMICAL2chr11:12261132chr11:14317401ENST00000256194+17282_4947381155RegionMonooxygenase domain
HgeneMICAL2chr11:12261132chr11:14317401ENST00000342902+16262_4947381099RegionMonooxygenase domain
HgeneMICAL2chr11:12261132chr11:14317401ENST00000379612+15192_494738977RegionMonooxygenase domain
HgeneMICAL2chr11:12261132chr11:14317401ENST00000527546+16222_494738935RegionMonooxygenase domain
HgeneMICAL2chr11:12261132chr11:14317401ENST00000537344+17232_494738935RegionMonooxygenase domain
TgeneRRAS2chr11:12261132chr11:14317401ENST00000256196-0643_5136205MotifNote=Effector region
TgeneRRAS2chr11:12261132chr11:14317401ENST00000414023--1543_51-12128MotifNote=Effector region
TgeneRRAS2chr11:12261132chr11:14317401ENST00000526063-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:12261132chr11:14317401ENST00000529237-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:12261132chr11:14317401ENST00000532814-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:12261132chr11:14317401ENST00000534746-0643_51-41128MotifNote=Effector region
TgeneRRAS2chr11:12261132chr11:14317401ENST00000537760-0643_511170MotifNote=Effector region
TgeneRRAS2chr11:12261132chr11:14317401ENST00000256196-06127_13036205Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000256196-06157_15936205Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000256196-0668_7236205Nucleotide bindingGTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000414023--15127_130-12128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000414023--15157_159-12128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000414023--1521_29-12128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000414023--1568_72-12128Nucleotide bindingGTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000526063-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000526063-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000526063-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000526063-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000529237-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000529237-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000529237-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000529237-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000532814-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000532814-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000532814-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000532814-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000534746-06127_130-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000534746-06157_159-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000534746-0621_29-41128Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000534746-0668_72-41128Nucleotide bindingGTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000537760-06127_1301170Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000537760-06157_1591170Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000537760-0621_291170Nucleotide bindingNote=GTP
TgeneRRAS2chr11:12261132chr11:14317401ENST00000537760-0668_721170Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMICAL2chr11:12261132chr11:14317401ENST00000256194+17281000_10627381155DomainLIM zinc-binding
HgeneMICAL2chr11:12261132chr11:14317401ENST00000342902+16261000_10627381099DomainLIM zinc-binding
HgeneMICAL2chr11:12261132chr11:14317401ENST00000379612+15191000_1062738977DomainLIM zinc-binding
HgeneMICAL2chr11:12261132chr11:14317401ENST00000527546+16221000_1062738935DomainLIM zinc-binding
HgeneMICAL2chr11:12261132chr11:14317401ENST00000537344+17231000_1062738935DomainLIM zinc-binding
TgeneRRAS2chr11:12261132chr11:14317401ENST00000256196-0621_2936205Nucleotide bindingNote=GTP


Top

FusionGeneSequence for MICAL2_RRAS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_907aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQ
RQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKG

>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_907aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQ
RQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKG

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_907aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQ
RQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKG

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_907aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQ
RQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKG

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_907aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQ
RQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKG

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_738aa
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCL
IVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIF
NQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQ
TTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVD
SWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_2721nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAA
GATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATG
AGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAA
AGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACA
CAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTC
CATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGC

>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_2721nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAA
GATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATG
AGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAA
AGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACA
CAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTC
CATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGC

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_2721nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAA
GATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATG
AGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAA
AGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACA
CAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTC
CATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGC

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_2721nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAA
GATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATG
AGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAA
AGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACA
CAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTC
CATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGC

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_2721nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAA
GATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATG
AGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAA
AGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACA
CAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTC
CATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGC

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_2214nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_3185nt
ATGCACTGAGGTACCAAGACTAATGAAGGTCCGGCCCTCCCCAGTGTAGGAGGCAGGTAAATGATCACACTGTGACAAATGCTCAAACGG
GGATGTGCTTGCAAAGGCTAGAGACAGCACGGGAGGAAGGAGCAGTCCATTCTGCTGAGAGTGTGAGTACCGAGAAAGCATGGCACTGGG
CTTGAAGGATGAGGAGTTCGCCAGACACAGAGGATGAGGAGAGCAGCACGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAG
ACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACT
GCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCC
ACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTC
AAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCG
TGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTC
GTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAG
AAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTG
GGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAA
TTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGA
AGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATT
AGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAG
GACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATG
CTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCC
TTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTG
CGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGT
GGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGT
CTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAAC
CTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCG
GTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTAC
CAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATC
AACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTG
ACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGC
ACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTAT
CTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTC
ACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAAC
AAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTTTTTTCTTTTCTTG
CAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGAT
ATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTC
ACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATT
GGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAG
GCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGAACAATGAGATGGTGGAGCTACAGAGAA
TACGGATGAAGGATGAAATCCGAGAATATAAGTTCCGGGAGGCACGGCTCCTTCAGGACTATACTGAATTGGAAGAAGAAAATATCACAT

>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_4513nt
ATGCACTGAGGTACCAAGACTAATGAAGGTCCGGCCCTCCCCAGTGTAGGAGGCAGGTAAATGATCACACTGTGACAAATGCTCAAACGG
GGATGTGCTTGCAAAGGCTAGAGACAGCACGGGAGGAAGGAGCAGTCCATTCTGCTGAGAGTGTGAGTACCGAGAAAGCATGGCACTGGG
CTTGAAGGATGAGGAGTTCGCCAGACACAGAGGATGAGGAGAGCAGCACGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAG
ACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACT
GCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCC
ACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTC
AAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCG
TGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTC
GTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAG
AAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTG
GGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAA
TTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGA
AGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATT
AGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAG
GACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATG
CTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCC
TTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTG
CGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGT
GGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGT
CTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAAC
CTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCG
GTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTAC
CAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATC
AACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTG
ACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGC
ACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTAT
CTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTC
ACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAAC
AAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACG
GATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGA
CAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTT
GAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTG
GATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGG
ATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGG
AAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTC
TCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAG
TCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAA
ATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCA
AGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAA
TGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTC
AGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAAC
CCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACT
TGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTA
AGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTA
TATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTG
TATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTT
TTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAG
ACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACT
GTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTAT
TGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAGAATTAAAA

>In-frame_MICAL2_ENST00000537344_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_4479nt
ATGCACTGAGGTACCAAGACTAATGAAGGTCCGGCCCTCCCCAGTGTAGGAGGCAGGTAAATGATCACACTGTGACAAATGCTCAAACGG
GGATGTGCTTGCAAAGGCTAGAGACAGCACGGGAGGAAGGAGCAGTCCATTCTGCTGAGAGTGTGAGTACCGAGAAAGCATGGCACTGGG
CTTGAAGGATGAGGAGTTCGCCAGACACAGAGGATGAGGAGAGCAGCACGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAG
ACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACT
GCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCC
ACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTC
AAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCG
TGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTC
GTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAG
AAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTG
GGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAA
TTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGA
AGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATT
AGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAG
GACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATG
CTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCC
TTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTG
CGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGT
GGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGT
CTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAAC
CTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCG
GTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTAC
CAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATC
AACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTG
ACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGC
ACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTAT
CTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTC
ACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAAC
AAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGCAGTCCTATTTTGT
AACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGC
AGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAG
TTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGA
TCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGAT
TAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAAC
ACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCAT
CTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGG
CTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTT
TAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTT
GCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTT
TTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCA
TCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATA
AAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTG
TACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTG
GGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTT
GCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCT
TGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGA
ACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGA
TGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTAT
AACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTG

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_4400nt
CTCGGCTGGCTAAGCCTGCGCCGGGCCGCCTCGCTCGCTCCCAGCTCTGTCAGTGGCCCGCGGGGCCCGATCGCTGCGCCCGCGGCCAGG
GCCGAGGCAGGCCTGACCCGGGGCCGGGCAGCCCGCGCGACTTTCGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACT
TTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCC
GCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACG
TGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAG
TCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGC
ACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTG
GTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAG
TTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGA
GTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTT
CTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGA
AAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGT
GGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGAC
TGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTG
CTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTA
GACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGG
GAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGC
TTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTC
TACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTC
AACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTG
AGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAG
CATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAAC
TTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACC
ACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACC
CCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTC
AACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACC
AACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAA
GTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTTTTTTCTTTTCTTGCAG
TCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATT
TTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACA
GATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGT
AATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCA
TCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCA
CCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGA
AAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGAC
GAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTA
TCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAAT
CTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATA
TAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACA
AAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAA
AACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAG
ATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTC
AAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGA
TTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTC
ATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAA
ACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGA
GTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGG
ATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGA

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_4420nt
CTCGGCTGGCTAAGCCTGCGCCGGGCCGCCTCGCTCGCTCCCAGCTCTGTCAGTGGCCCGCGGGGCCCGATCGCTGCGCCCGCGGCCAGG
GCCGAGGCAGGCCTGACCCGGGGCCGGGCAGCCCGCGCGACTTTCGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACT
TTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCC
GCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACG
TGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAG
TCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGC
ACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTG
GTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAG
TTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGA
GTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTT
CTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGA
AAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGT
GGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGAC
TGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTG
CTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTA
GACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGG
GAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGC
TTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTC
TACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTC
AACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTG
AGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAG
CATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAAC
TTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACC
ACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACC
CCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTC
AACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACC
AACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAA
GTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGAT
TATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAA
GAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAA
GAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGAT
CATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATG
AATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAA
GAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCT
TTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCC
TTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATA
TATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGC
TGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGT
GAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGA
CCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCT
GTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGA
TTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGG
GATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATAT
ACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTAT
ATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTA
CTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACT
CTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTG
GATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGC
ACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAGAATTAAAATTG

>In-frame_MICAL2_ENST00000256194_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_4386nt
CTCGGCTGGCTAAGCCTGCGCCGGGCCGCCTCGCTCGCTCCCAGCTCTGTCAGTGGCCCGCGGGGCCCGATCGCTGCGCCCGCGGCCAGG
GCCGAGGCAGGCCTGACCCGGGGCCGGGCAGCCCGCGCGACTTTCGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACT
TTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCC
GCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACG
TGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAG
TCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGC
ACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTG
GTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAG
TTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGA
GTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTT
CTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGA
AAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGT
GGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGAC
TGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTG
CTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTA
GACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGG
GAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGC
TTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTC
TACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTC
AACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTG
AGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAG
CATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAAC
TTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACC
ACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACC
CCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTC
AACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACC
AACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAA
GTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGCAGTCCTATTTTGTAAC
GGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGG
ACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTT
TGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCT
GGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAG
GATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACG
GAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTT
CTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTA
GTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAA
AATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCC
AAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTA
ATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCT
CAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAA
CCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTAC
TTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGT
AAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCT
ATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGT
GTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACT
TTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGA
GACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAAC
TGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTA

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_4266nt
AGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCT
CCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCA
GGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCT
GGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATT
GGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTT
GCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCT
CTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTAT
TCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCC
TCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCAT
CATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTT
CATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAA
AGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCT
CGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGC
CCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTT
TGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAG
CTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAA
CCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAA
CTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATAT
CACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCC
CAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTT
GGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCT
CGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAG
CATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAA
TGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCA
AACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTC
CAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAG
CACTCGGAACCCCTCACTCATGAAGCAGTTTTTTCTTTTCTTGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTA
CACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACA
GTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGAT
TCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGA
AGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACT
TGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTG
TGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTG
GTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCA
TTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCT
TTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTT
TTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTT
CAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTT
TTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGAT
GATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAG
CCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTG
TTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAA
ACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCA
CTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACC
CATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGC
TAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATT
CTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTA

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_4286nt
AGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCT
CCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCA
GGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCT
GGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATT
GGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTT
GCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCT
CTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTAT
TCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCC
TCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCAT
CATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTT
CATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAA
AGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCT
CGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGC
CCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTT
TGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAG
CTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAA
CCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAA
CTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATAT
CACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCC
CAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTT
GGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCT
CGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAG
CATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAA
TGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCA
AACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTC
CAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAG
CACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGAT
AGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGA
AGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCG
TGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACG
GCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAA
ATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCC
CTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAG
ACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAA
GGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACAT
TTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATA
CTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTA
ACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATAC
CAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGT
CAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAA
GGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATG
GAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTT
TTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGA
CAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACA
TAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATT
TCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAG
CAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTT

>In-frame_MICAL2_ENST00000527546_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_4252nt
AGGAACATGGCAACCCGTGTGTGTCTCATCCCAGAAAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCT
CCAGATACTTCATGCTGTTCACCTGTGTCCTCGCCGCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCA
GGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCT
GGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATT
GGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTT
GCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCT
CTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTAT
TCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCC
TCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCAT
CATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTT
CATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAA
AGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCT
CGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGC
CCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTT
TGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAG
CTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAA
CCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAA
CTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATAT
CACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCC
CAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTT
GGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCT
CGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAG
CATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAA
TGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCA
AACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTC
CAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAG
CACTCGGAACCCCTCACTCATGAAGCAGGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTG
TGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTG
GCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGG
ATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAG
CACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCA
GGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGA
ATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCC
TTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATT
TAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTT
ACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAAT
CATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTT
GTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAA
ATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATG
TGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTA
AAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAA
TATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGT
ATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAA
CTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGT
CACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGT
TATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTT
TAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGA

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_4231nt
AAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCC
GCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCC
AGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATT
CCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAG
GGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCA
AAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGG
GAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCC
TGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGC
GGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAG
GGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGG
AAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTT
ACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACA
CAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGC
TGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGG
CCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCT
GTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAA
GGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGT
ACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGAC
TGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAG
AGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTG
AGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCC
CTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCT
TCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTA
ATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGA
AGGGCTTCACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAA
ATCAGAACAAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTTTTTTC
TTTTCTTGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCC
GGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCT
TTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGA
TTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACAT
ACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAAT
GTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACC
AACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGT
TAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGC
TTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATC
AGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCT
AAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAA
TTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATT
TATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCAT
TTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTG
TCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGG
GTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCA
GATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGG
AAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACC
TTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAA
GCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTT
CCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTG

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_4251nt
AAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCC
GCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCC
AGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATT
CCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAG
GGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCA
AAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGG
GAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCC
TGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGC
GGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAG
GGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGG
AAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTT
ACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACA
CAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGC
TGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGG
CCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCT
GTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAA
GGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGT
ACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGAC
TGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAG
AGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTG
AGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCC
CTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCT
TCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTA
ATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGA
AGGGCTTCACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAA
ATCAGAACAAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATT
TTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATA
CAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAG
GCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAG
CAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAA
AGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAAC
CAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCC
TCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAG
CTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATT
CCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCT
GTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTT
TTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGA
ACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCT
TATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTC
AGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATT
TCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGT
TTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCAT
ACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGG
TAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAAC
AGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTA
GTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTA
AGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAG

>In-frame_MICAL2_ENST00000342902_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_4217nt
AAGAGAAGACTTTAACCACTGTGATGCCTGAGAATCCAGTGAGTGTGACGTTTCTCCAGATACTTCATGCTGTTCACCTGTGTCCTCGCC
GCACCACTGCCGCACACGACTCCTGAACCATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCC
AGGCATCCACGTGCAAAGGTACCCTCCAGGCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATT
CCAAGCTCAAGTCCAAGGTGACCACCTGGAAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAG
GGAAGTCGTGCACGAACACCAAGTGTCTCATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCA
AAGTGGTCGTGGTGGAGAAGAGGGACTCCTTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGG
GAGCCAAGAAGTTCTATGGGAAGTTCTGTGCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCC
TGATGCTGGGAGTTGAAATCCATGTGAATGTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGC
GGGCAGAATTTCTCCCTACAGACCATTCTCTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAG
GGTTCAGAAGAAAAGAATTCCGTGGGAAGCTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGG
AAGAGATTAGTGGTGTGGCTTTCATCTTCAATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTT
ACTACAAGGACTGCACCCACTATTTTGTAATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACA
CAGAGATGCTGCTGTGTGCGGAGAACGTGAACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGC
TGCCATCCTTAGACTTTGCCATGAACCACTATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGG
CCCTGGTGCGGGAGCGGCAGGCGCACCAGCTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCT
GTGCCCGTGGCTTCCTGGCAGCCTTTGACACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAA
GGGAAAGTCTCTACCGGCTGTTACCTCAGACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGT
ACCCAAACCTCAACTCACACTGTGTCAGGCCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGAC
TGGGCTCGGTGAGGAGATCTGTCAACCTCTCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAG
AGGGCTACCAGCATGTCAACGTCACCGACCTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTG
AGCTCATCAACTTTGACTCTTTGAATGAAGATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCC
CTCCAGTGACCACGGGCAAAGAGATGGCATCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCT
TCCGGGGCACCCCACTGAGGCCCGTGGATTCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTA
ATAACTATCTCAACCTCACATTTCCAAGGAAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGA
AGGGCTTCACCAACCTGGACGAGCCTTCAAACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAA
ATCAGAACAAAGTCAAGTCCATGGCGAATCAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGCAGTCC
TATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTG
GATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGAT
AGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAAT
AAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCA
GCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCA
GAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAA
GCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAA
GAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCT
GATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTA
AGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAG
GGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAA
GTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAAC
TGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATA
TTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAG
TATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTA
ATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATA
GCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACT
GTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTA
CAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATA
ATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGAT

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000545643_chr11_14317401_-_4112nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTTTTTTCTTTTCTTGCAGTCCTATTTTGTAACGGAT
TATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAA
GAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAA
GAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGAT
CATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATG
AATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAA
GAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCT
TTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCC
TTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATA
TATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGC
TGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGT
GAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGA
CCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCT
GTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGA
TTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGG
GATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATAT
ACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTAT
ATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTA
CTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACT
CTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTG
GATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGC

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000537760_chr11_14317401_-_4132nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAA
GATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATG
AGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAA
AGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACA
CAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTC
CATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGC
TGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACA
TCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATAC
AATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGA
CATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGA
AATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTT
AAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAA
CTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTC
TTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTT
TTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAAC
TGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTT
CTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTT
AATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTG
GTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTA
TTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGT
TTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCA

>In-frame_MICAL2_ENST00000379612_chr11_12261132_+_RRAS2_ENST00000414023_chr11_14317401_-_4098nt
ATGGGGGAAAACGAGGATGAGAAGCAGGCCCAGGCGGGGCAGGTTTTTGAGAACTTTGTCCAGGCATCCACGTGCAAAGGTACCCTCCAG
GCCTTCAACATTCTCACACGACACCTGGACCTAGACCCTCTGGACCACAGAAACTTTTATTCCAAGCTCAAGTCCAAGGTGACCACCTGG
AAAGCCAAAGCCCTGTGGTACAAATTGGATAAGCGTGGTTCCCACAAAGAGTATAAGCGAGGGAAGTCGTGCACGAACACCAAGTGTCTC
ATAGTTGGGGGAGGACCCTGTGGCTTGCGCACTGCCATTGAACTTGCCTACCTGGGAGCCAAAGTGGTCGTGGTGGAGAAGAGGGACTCC
TTCTCCCGGAACAACGTGCTACACCTCTGGCCTTTCACCATCCATGACCTTCGTGGCCTGGGAGCCAAGAAGTTCTATGGGAAGTTCTGT
GCTGGCTCCATCGACCATATCAGTATTCGCCAACTACAGCTCATCCTATTCAAGGTGGCCCTGATGCTGGGAGTTGAAATCCATGTGAAT
GTGGAGTTCGTGAAGGTTCTAGAGCCTCCTGAAGATCAAGAAAATCAAAAAATTGGCTGGCGGGCAGAATTTCTCCCTACAGACCATTCT
CTGTCGGAGTTTGAGTTTGACGTCATCATTGGTGCCGATGGCCGCAGGAACACCCTGGAAGGGTTCAGAAGAAAAGAATTCCGTGGGAAG
CTGGCGATTGCCATCACCGCCAACTTCATAAACAGAAACAGCACAGCGGAAGCCAAGGTGGAAGAGATTAGTGGTGTGGCTTTCATCTTC
AATCAGAAATTTTTTCAGGACCTTAAAGAAGAAACAGGCATAGATCTTGAGAACATTGTTTACTACAAGGACTGCACCCACTATTTTGTA
ATGACAGCCAAGAAGCAGAGCCTGCTCGACAAAGGTGTCATCATTAACGACTACATCGACACAGAGATGCTGCTGTGTGCGGAGAACGTG
AACCAAGACAACCTGCTATCCTATGCCCGGGAAGCTGCAGACTTTGCCACCAACTACCAGCTGCCATCCTTAGACTTTGCCATGAACCAC
TATGGGCAGCCTGATGTGGCCATGTTTGACTTTACCTGCATGTATGCCTCAGAGAACGCGGCCCTGGTGCGGGAGCGGCAGGCGCACCAG
CTGCTCGTGGCCCTTGTGGGTGACAGCTTGCTTGAGCCATTTTGGCCCATGGGTACAGGCTGTGCCCGTGGCTTCCTGGCAGCCTTTGAC
ACGGCATGGATGGTGAAGAGCTGGAACCAGGGCACCCCTCCCCTGGAGCTGCTGGCTGAAAGGGAAAGTCTCTACCGGCTGTTACCTCAG
ACAACCCCGGAGAACATCAACAAGAACTTTGAGCAGTACACGTTGGACCCAGGGACACGGTACCCAAACCTCAACTCACACTGTGTCAGG
CCCCATCAGGTGAAGCATTTGTATATCACTAAGGAGCTGGAGCACTACCCTCTCGAGAGACTGGGCTCGGTGAGGAGATCTGTCAACCTC
TCCAGGAAGGAGTCAGATATCCGGCCCAGCAAGCTCCTGACCTGGTGCCAGCAGCAGACAGAGGGCTACCAGCATGTCAACGTCACCGAC
CTGACCACATCCTGGCGCAGTGGGTTGGCCCTGTGTGCCATCATCCACCGCTTCCGGCCTGAGCTCATCAACTTTGACTCTTTGAATGAA
GATGATGCTGTGGAGAACAACCAGCTCGCATTTGATGTGGCCGAGCGAGAGTTTGGGATCCCTCCAGTGACCACGGGCAAAGAGATGGCA
TCTGCCCAGGAGCCTGACAAGCTCAGCATGGTCATGTACCTCTCCAAGTTCTACGAGCTCTTCCGGGGCACCCCACTGAGGCCCGTGGAT
TCTTGGCGCAAAAACTATGGAGAAAATGCTGACCTCAGCTTGGCCAAATCATCCATTTCTAATAACTATCTCAACCTCACATTTCCAAGG
AAGAGGACTCCACGGGTGGATGGTCAAACCGGAGAGAATGACATGAACAAACGGAGACGGAAGGGCTTCACCAACCTGGACGAGCCTTCA
AACTTTTCCAGCCGTAGCTTGGGCTCCAATCAAGAGTGTGGGAGCAGTAAGGAAGGTGGAAATCAGAACAAAGTCAAGTCCATGGCGAAT
CAGCTGCTGGCCAAGTTTGAGGAGAGCACTCGGAACCCCTCACTCATGAAGCAGGCAGTCCTATTTTGTAACGGATTATGATCCAACCAT
TGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGC
CATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTT
TCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGT
AACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGC
TTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAA
AGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTT
TACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTA
ATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACA
CAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTT
GTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTAT
CTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACT
ACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCT
ACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAAC
TCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTA
AAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTA
TTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGT
ATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGT
CTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTC
AGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATT
TTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTT


Top

FusionGenePPI for MICAL2_RRAS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MICAL2PTPRN, JPH4RRAS2LGALS4, XRCC6, RAF1, PIK3R1, RALGDS, RIN1, MLLT4, CDK2, PAN2, TRAF2, CREB3, ARAF, CCDC8, RABGGTB, FNTB, DBN1, SNCA, TSNAX, SYNPO, LIMA1, FOXS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MICAL2_RRAS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MICAL2_RRAS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRRAS2C0023904Liver Neoplasms, Experimental1CTD_human
TgeneRRAS2C0349639Juvenile Myelomonocytic Leukemia1CTD_human