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Fusion gene ID: 21878 |
FusionGeneSummary for MICAL2_NELL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MICAL2_NELL1 | Fusion gene ID: 21878 | Hgene | Tgene | Gene symbol | MICAL2 | NELL1 | Gene ID | 9645 | 4745 |
| Gene name | microtubule associated monooxygenase, calponin and LIM domain containing 2 | neural EGFL like 1 | |
| Synonyms | MICAL-2|MICAL2PV1|MICAL2PV2 | IDH3GL|NRP1 | |
| Cytomap | 11p15.3 | 11p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | [F-actin]-monooxygenase MICAL2[F-actin]-methionine sulfoxide oxidase MICAL2flavoprotein oxidoreductase MICAL2microtubule associated monoxygenase, calponin and LIM domain containing 2molecule interacting with CasL protein 2protein-methionine sulfoxide | protein kinase C-binding protein NELL1nel-related protein 1neural epidermal growth factor-like 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O94851 | Q92832 | |
| Ensembl transtripts involved in fusion gene | ENST00000537344, ENST00000256194, ENST00000527546, ENST00000342902, ENST00000379612, ENST00000527195, | ENST00000298925, ENST00000357134, ENST00000325319, ENST00000532434, ENST00000529218, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/60*10)=0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MICAL2 [Title/Abstract] AND NELL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MICAL2 | GO:0007010 | cytoskeleton organization | 24440334 |
| Hgene | MICAL2 | GO:0030042 | actin filament depolymerization | 24440334 |
| Hgene | MICAL2 | GO:0055114 | oxidation-reduction process | 24440334 |
| Tgene | NELL1 | GO:0010468 | regulation of gene expression | 21723284 |
| Tgene | NELL1 | GO:0030501 | positive regulation of bone mineralization | 21723284 |
| Tgene | NELL1 | GO:0033689 | negative regulation of osteoblast proliferation | 21723284 |
| Tgene | NELL1 | GO:0045669 | positive regulation of osteoblast differentiation | 21723284 |
| Tgene | NELL1 | GO:1903363 | negative regulation of cellular protein catabolic process | 21723284 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1KU-01A | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000537344 | ENST00000298925 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000537344 | ENST00000357134 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000537344 | ENST00000325319 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000537344 | ENST00000532434 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| 5CDS-3UTR | ENST00000537344 | ENST00000529218 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000256194 | ENST00000298925 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000256194 | ENST00000357134 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000256194 | ENST00000325319 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000256194 | ENST00000532434 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| 5CDS-3UTR | ENST00000256194 | ENST00000529218 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000527546 | ENST00000298925 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000527546 | ENST00000357134 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000527546 | ENST00000325319 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000527546 | ENST00000532434 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| 5CDS-3UTR | ENST00000527546 | ENST00000529218 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000342902 | ENST00000298925 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000342902 | ENST00000357134 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000342902 | ENST00000325319 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000342902 | ENST00000532434 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| 5CDS-3UTR | ENST00000342902 | ENST00000529218 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000379612 | ENST00000298925 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000379612 | ENST00000357134 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000379612 | ENST00000325319 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| Frame-shift | ENST00000379612 | ENST00000532434 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| 5CDS-3UTR | ENST00000379612 | ENST00000529218 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| intron-3CDS | ENST00000527195 | ENST00000298925 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| intron-3CDS | ENST00000527195 | ENST00000357134 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| intron-3CDS | ENST00000527195 | ENST00000325319 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| intron-3CDS | ENST00000527195 | ENST00000532434 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
| intron-3UTR | ENST00000527195 | ENST00000529218 | MICAL2 | chr11 | 12183966 | + | NELL1 | chr11 | 21392399 | + |
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FusionProtFeatures for MICAL2_NELL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MICAL2 | NELL1 |
| Nuclear monooxygenase that promotes depolymerization ofF-actin by mediating oxidation of specific methionine residues onactin to form methionine-sulfoxide, resulting in actin filamentdisassembly and preventing repolymerization. In the absence ofactin, it also functions as a NADPH oxidase producing H(2)O(2) (Bysimilarity). Acts as a key regulator of the SRF signaling pathwayelicited by nerve growth factor and serum: mediates oxidation andsubsequent depolymerization of nuclear actin, leading to increaseMKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-Athrough RhoA. {ECO:0000250|UniProtKB:Q8BML1,ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}. | Plays a role in the control of cell growth anddifferentiation. Promotes osteoblast cell differentiation andterminal mineralization. {ECO:0000269|PubMed:21723284}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MICAL2_NELL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MICAL2_NELL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MICAL2 | PTPRN, JPH4 | NELL1 | ATXN7, CACNA1A, ATN1, GFI1B, EGFR, MATN2, PFKP, FBXO27, PXDN, ZNF260, TRMT2B, EMILIN2, TP53RK, TIMP3, EGFL7, C4orf48, POLRMT, TYW3, LTBP4, CEP44, FBLN1, LAMB2, OBSL1, C10orf88, CHEK1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MICAL2_NELL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MICAL2_NELL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NELL1 | C0010278 | Craniosynostosis | 1 | CTD_human |
| Tgene | NELL1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | NELL1 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
| Tgene | NELL1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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