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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21873

FusionGeneSummary for MIB2_PSMD3

check button Fusion gene summary
Fusion gene informationFusion gene name: MIB2_PSMD3
Fusion gene ID: 21873
HgeneTgene
Gene symbol

MIB2

PSMD3

Gene ID

142678

5709

Gene namemindbomb E3 ubiquitin protein ligase 2proteasome 26S subunit, non-ATPase 3
SynonymsZZANK1|ZZZ5P58|RPN3|S3|TSTA2
Cytomap

1p36.33

17q21.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase MIB2RING-type E3 ubiquitin transferase MIB2mind bomb homolog 2mindbomb homolog 2novel zinc finger proteinnovelzinputative NF-kappa-B-activating protein 002Nskeletrophinzinc finger ZZ type with ankyrin repeat domain prot26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN326S proteasome regulatory subunit S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3proteasome subunit p58tissue specific transplantation antigen 2
Modification date2018052320180523
UniProtAcc

Q96AX9

O43242

Ensembl transtripts involved in fusion geneENST00000520777, ENST00000360522, 
ENST00000378710, ENST00000357210, 
ENST00000355826, ENST00000518681, 
ENST00000505820, ENST00000378712, 
ENST00000504599, ENST00000378708, 
ENST00000512004, 		ENST00000264639, 
ENST00000541736, 
Fusion gene scores* DoF score4 X 3 X 3=3610 X 9 X 6=540
# samples 411
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIB2 [Title/Abstract] AND PSMD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ361077MIB2chr1

1561050

-PSMD3chr17

38145990

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000520777ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000520777ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000360522ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000360522ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000378710ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000378710ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000357210ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000357210ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000355826ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000355826ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000518681ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000518681ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000505820ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000505820ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000378712ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000378712ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000504599ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000504599ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000378708ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000378708ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000512004ENST00000264639MIB2chr1

1561050

-PSMD3chr17

38145990

+
intron-3CDSENST00000512004ENST00000541736MIB2chr1

1561050

-PSMD3chr17

38145990

+

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FusionProtFeatures for MIB2_PSMD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MIB2

Q96AX9

PSMD3

O43242

Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair.{ECO:0000269|PubMed:1317798}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MIB2_PSMD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MIB2_PSMD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MIB2_PSMD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MIB2_PSMD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSMD3C0019693HIV Infections1CTD_human