	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 21851

FusionGeneSummary for MGST3_SLAMF7

Fusion gene summary

Fusion gene information	Fusion gene name: MGST3_SLAMF7
	Fusion gene ID: 21851
		Hgene	Tgene
	Gene symbol	MGST3	SLAMF7
	Gene ID	4259	57823
	Gene name	microsomal glutathione S-transferase 3	SLAM family member 7
	Synonyms	GST-III	19A\|CD319\|CRACC\|CS1
	Cytomap	1q24.1	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	microsomal glutathione S-transferase 3microsomal GST-3microsomal GST-IIImicrosomal glutathione S-transferase III	SLAM family member 719A24 proteinCD2 subset 1CD2-like receptor activating cytotoxic cellsmembrane protein FOAP-12novel LY9 (lymphocyte antigen 9) like proteinprotein 19A
	Modification date	20180523	20180519
	UniProtAcc	O14880	Q9NQ25
	Ensembl transtripts involved in fusion gene	ENST00000367889, ENST00000367888, ENST00000367885, ENST00000367884, ENST00000367883, ENST00000367886, ENST00000461759,	ENST00000488819, ENST00000444090, ENST00000441662, ENST00000368043, ENST00000368042, ENST00000458602, ENST00000458104, ENST00000359331,
Fusion gene scores	* DoF score	4 X 3 X 3=36	2 X 1 X 2=4
	# samples	4	2
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/4*10)=2.32192809488736
Context	PubMed: MGST3 [Title/Abstract] AND SLAMF7 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MGST3	GO:0006629	lipid metabolic process	9278457
Hgene	MGST3	GO:0019370	leukotriene biosynthetic process	9278457

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-B6-A0I1-01A	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3UTR	ENST00000367889	ENST00000488819	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367889	ENST00000444090	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367889	ENST00000441662	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367889	ENST00000368043	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367889	ENST00000368042	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367889	ENST00000458602	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367889	ENST00000458104	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367889	ENST00000359331	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367888	ENST00000488819	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367888	ENST00000444090	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367888	ENST00000441662	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367888	ENST00000368043	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367888	ENST00000368042	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367888	ENST00000458602	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367888	ENST00000458104	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367888	ENST00000359331	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367885	ENST00000488819	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367885	ENST00000444090	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367885	ENST00000441662	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367885	ENST00000368043	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367885	ENST00000368042	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367885	ENST00000458602	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367885	ENST00000458104	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367885	ENST00000359331	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367884	ENST00000488819	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367884	ENST00000444090	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367884	ENST00000441662	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-3UTR	ENST00000367884	ENST00000368043	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367884	ENST00000368042	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367884	ENST00000458602	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367884	ENST00000458104	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
5UTR-intron	ENST00000367884	ENST00000359331	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367883	ENST00000488819	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367883	ENST00000444090	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367883	ENST00000441662	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367883	ENST00000368043	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367883	ENST00000368042	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367883	ENST00000458602	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367883	ENST00000458104	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367883	ENST00000359331	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367886	ENST00000488819	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367886	ENST00000444090	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367886	ENST00000441662	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000367886	ENST00000368043	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367886	ENST00000368042	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367886	ENST00000458602	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367886	ENST00000458104	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000367886	ENST00000359331	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000461759	ENST00000488819	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000461759	ENST00000444090	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000461759	ENST00000441662	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-3UTR	ENST00000461759	ENST00000368043	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000461759	ENST00000368042	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000461759	ENST00000458602	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000461759	ENST00000458104	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+
intron-intron	ENST00000461759	ENST00000359331	MGST3	chr1	165600530	+	SLAMF7	chr1	160717984	+

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FusionProtFeatures for MGST3_SLAMF7

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MGST3 O14880	SLAMF7 Q9NQ25
Also functions as a glutathione peroxidase.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for MGST3_SLAMF7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MGST3_SLAMF7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
MGST3	ELAVL1, ZMPSTE24, MRPL49, MRPS26, ATP6V1C1, FAM3C, NDUFS4, CCNC, UNK, CNTRL, FBF1, VAPA, GOLT1B, MCM2, HRAS, S100A13, NMT1, GLMN, NMT2, GAPDHS, HSPA12A, BIRC6, RAP1A, SVIP, ATP6V0A1, LMNA	SLAMF7	SLAMF7, MAK, TRIB2, CLK3, LEMD3, HUS1, APBB1, TBC1D23, PTCD2, FBXO2, NAGPA, YIF1A, LGALS1, DAGLB, CTNNA1, CTNNB1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for MGST3_SLAMF7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	MGST3	O14880	DB00143	Glutathione	Microsomal glutathione S-transferase 3	small molecule	approved\|investigational\|nutraceutical

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RelatedDiseases for MGST3_SLAMF7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 21851

FusionGeneSummary for MGST3_SLAMF7

FusionProtFeatures for MGST3_SLAMF7

FusionGeneSequence for MGST3_SLAMF7

FusionGenePPI for MGST3_SLAMF7

RelatedDrugs for MGST3_SLAMF7

RelatedDiseases for MGST3_SLAMF7